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REV_ISS_WEB_jnc_6650_113-4 836..847 *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK Wallenberg Neuroscience Centre, Lund University, Lund, Sweden The midbrain dopaminergic (mDA) neurons are the largest assembly of dopaminergic neurons in the central nervous system and play an important role in motor control, reward, addiction and cognition (Bjorklund and Lindvall 1
Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector HUMAN GENE THERAPY 15:934–944 (October 2004) © Mary Ann Liebert, Inc. Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector BILJANA GEORGIEVSKA,* JOHAN JAKOBSSON,* ELISABETH PERSSON, CEC
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-relate
Disease susceptibility mapping using spatial modeling techniques Author: Mohammadreza Rajabi Supervisors: Ali Mansourian , Petter Pilesjo GIS Center ,Department of Physical Geography and Ecosystem Science Lund University September, 2015 Disease susceptibility mapping using spatial modeling techniques ii Table of Contents 1- Introduction .............................................................
https://www.nateko.lu.se/sites/nateko.lu.se/files/mohammadreza-rajabi-first_year_seminar-17-08-2015-v4.pdf - 2026-07-13
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identifie
It is often said that we live in a consumer society. This does not just mean that we buy things regularly but also that consumption is an integral part of our daily lives. We have learned to think of ourselves as consumers, rather than citizens, in a variety of situations. Against this backdrop, retail organisations hold a strategically important position, not least because of the space they occup
Anonymisation of assessments has been discussed for decades. It stems from a concern about unduly bias in assessment and grading. In Sweden, anonymised assessments were introduced in many universities a decade ago. It was rarely preceded by discussions on potential pedagogical consequences. Recent research on the effects of anonymisation does not confirm the hypothesis of reduced bias in grading.
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitor cells. Two subsets, plasmacytoid DCs (pDCs) and myeloid DCs (mDCs), have been identified. Little is known regarding DC levels in bone marrow of patients with acute myeloid leukaemia (AML) before and after chemotherapy. We investigated relative pDC and mDC levels in bone marrow from 37 hospital controls and 60 patients
Urban planning regulations influence not only the urban form; they also have a great impact on the microclimate in urban areas. This paper deals with the relationship between the urban planning regulations and microclimate in the hot dry city of Damascus. The main purpose is to highlight the shortcomings of the existing urban planning regulations. The microclimatic parameters necessary for the the
Upon tissue injury and infection both stressed and dying cells can release proteins that normally reside inside the cells. Some of the released proteins become ligands of various cell surface receptors expressed by local cells and such proteins are denoted damage associated molecular patterns (DAMPs). Binding of some DAMPs to certain cell surface receptors induces signals emanating in the producti
Mid-infrared polarization spectroscopy (IRPS) and laser-induced fluorescence (IRLIF) have been applied for detection of methane and ethane in atmospheric pressure cold flows and flames. Lines belonging to the asymmetric C-H stretching vibration bands v3 and v7 for methane and ethane, respectively, were probed with a tunable infrared laser beam at about 3.4 μm, which was obtai
Eosinophils participate in allergic inflammation and may have roles in the bodys defense against helminthic infestation. Even under noninflammatory conditions, eosinophils are present in the mucosa of the large intestine, where large numbers of gram-negative bacteria reside. Therefore, roles for eosinophils in host defenses against bacterial invasion are possible. In a system for bacterial viable
Generating proteomic maps of membrane proteins, common targets for therapeutic interventions and disease diagnostics, has turned out to be a major challenge. Antibody-based microarrays are among the novel rapidly evolving proteomic technologies that may enable global proteome analysis to be performed. Here, we have designed the first generation of a scaleable human recombinant scFv antibody microa
The driving force behind oncoproteomics is the belief that certain protein signatures or patterns exist that are associated with a particular malignancy. if so, the correlation of clinical parameters with defined protein expression patterns would allow us to predict disease progression and perhaps even postulate improved therapeutic modalities. The technological challenges to achieve these goals a
Doppler-free saturation spectroscopy in the regime of strong pumping intensities and optically thick atomic samples is investigated experimentally and theoretically. It is shown that a very high signal-to-background ratio can be obtained and, at the same time, subnatural linewidths can be reached. Further contrast and linewidth improvements can be attained by supplementing the primary depleted pum
Popular Abstract in Swedish Sandstäpp är ett starkt hotat växtsamhälle i Sverige som består av många specialiserade och hotade arter som t.ex. sandnejlika, tofsäxing och sandliljor. Exempel på hur en sandstäpp kan se ut hittas i Figur 1 i den Engelska sammanfattningen. Sandstäpp finns på sandig mark med kalk i ytjorden och ett lågt näringsinnehåll. Den karaktäriseras av ett uppbrutet växttäcke somA number of sandy grassland habitats of interest for biodiversity conservation can be found in Europe. One such habitat is the threatened xeric sand calcareous grassland, which is home to a large number of endangered species. It is characterized by a discontinuous vegetation cover, mainly consisting of stress-tolerant species favoured by nutrient-poor and dry conditions. The xeric sand calcareous
