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The Chemotaxis Inhibitory Protein of Staphylococcus aureus (CHIPS) binds and blocks the C5a receptor (C5aR) and formyl-peptide receptor (FPR). This way, CHIPS is a potent inhibitor of the immune cell recruitment associated with inflammation. Truncation of the protein and the introduction of mutations, shifts the expression towards the insoluble fraction of Escherichia coli, whereas the wild-type p

Metrical versions of the Passion form a significant part of the substantial body of devotional literature written in Europe during the 17th and 18th centuries. The aim underlying them was twofold: to meet the demand for works which could be used for purposes of educadon, edification, and private worship but also to show that the vanacul-ars could be used to produce distinguished works written in a

Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable

This book analyses and discusses the use of Islamic terms and symbols in the political party Sri Lanka Muslim Congress (SLMC). It is based on interviews with the leading members of the party and on analyses of the party’s official documents. It describes the history of Muslims in Sri Lanka, presents the analytical framework used, and discusses the official documents and narratives of party members

Cytoreduction followed by hyperthermic intraperitoneal chemotherapy is a treatment option for peritoneal surface malignancies in The Netherlands. This treatment has been available for more than 10 years. Therefore, long-term results on survival and quality of life can now be studied. With these results, the true long-term benefits of this new management strategy can be determined.

This chapter examines the institutional dimensions of religious responsesto forced migration in contemporary Georgia. It focuses on the internallydisplaced population of Georgia from the two breakaway territories ofAbkhazia and South Ossetia/Tskhinvali region to further scrutinise howmajor religious organisations respond to the signifijicant migration crises onthe level of policy and discourse. The

We present the results of a near-infrared (NIR) monitoring programme carried out between 1999 and 2005 to determine the variability properties of the 'Arecibo sample of OH/IR stars'. The sample consists of 385 IRAS-selected Asymptotic Giant Branch (AGB) candidates, for which their O-rich chemistry has been proven by the detection of 1612 MHz OH maser emission. The monitoring data were complemented

Immune responses activated by LDL particles that have been trapped and oxidized in the arterial wall play an important role in atherosclerosis. Some of these immune responses are protective by facilitating the removal of pro-inflammatory and toxic lipid species formed as result of LDL oxidation. However, should these protective immune responses be insufficient, other more potent pro-inflammatory i

Background: The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. Patients and Methods: We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-d

INTRODUCTION: Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. METHODS: A nationwide cohort study was conducted using Swedish family cancer data sets, inpatient, and o

The aim of this paper is to discuss how research schools with a structured programme and targeted profile may make it difficult for doctoral students to expand the academic role. Our paper is based on material collected in a questionnaire given to doctoral students enrolled at a Swedish research school in architecture. In this questionnaire we found three areas – openness to other disciplines and

Autoimmune hepatitis (AH) and primary biliary cirrhosis (PBC) are autoimmune diseases (AIDs) targeting cellular components of the liver. Being rare diseases, limited data are available about familial risks among these AIDs (concordant) or between them and other AIDs (discordant). We aimed to carry out an unbiased study on these AIDs based on medically diagnosed patients. We collected data on patie

The sulfation of gas-phase KOH and KCl was investigated in both oxidizing and reducing atmospheres at temperatures of 1120 K, 1260 K, 1390 K, and 1550 K. Well-defined gas environments were generated in a laminar flame burner fuelled with CH4/air/O2/N2. Atomized K2CO3 and KCl water solution fog and SO2 were introduced into the hot gas as sources of potassium, chlorine, and sulfur, respectively. The

SUMMARYVaccines work primarily by eliciting antibodies, even when recovery from natural infection depends on cellular immunity. Large efforts have therefore been made to identify microbial antigens that elicit protective antibodies, but these endeavors have encountered major difficulties, as witnessed by the lack of vaccines against many pathogens. This review summarizes accumulating evidence that

It has been argued that, when there is a probable imminent risk of loss of children's fertility, their parents should take active steps to preserve their reproductive potential if possible – or even that children have a right to such interventions being undertaken on them on their behalf, as an expression of their right to an open future. In this chapter, I explore these proposals and some of thei

The purpose of the present study is to introduce a point process model for characterizing the pattern of atrial fibrillation (AF) episodes. A variant of the bivariate Hawkes process is proposed, accounting for clustered episodes. The model parameters are inferred by the maximum likelihood method. The goodness-of-fit analysis show that model fits the data in most of the recordings (27 out of 32). T

Tumors affect the immune system, locally and systemically. The frequencies of specific circulating immune cell populations correlate with disease progression as well as prognosis of the patients. Although largely neglected, conventional antitumoral therapies often possess immunomodulatory properties and affect the levels of specific immune cell populations. Most information, however, derive from a

The problem of adversarial CNN attacks is considered, with an emphasis on attacks that are trivial to perform but difficult to defend. A framework for the study of such attacks is proposed, using real world object manipulations. Unlike most works in the past, this framework supports the design of attacks based on both small and large image perturbations, implemented by camera shake and pose variat

In the present paper, the effectiveness of a vibration isolation mat for a railway slab track system is studied using a finite element model of the railway track. The finite elements are formulated in a moving frame of reference following the moving load at a particular speed. The rails are modeled using Bernoulli beams, whereas the track slab and an underlying supporting plate are modeled using K