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Histidine is a key amino-acid residue in proteins with unique properties engendered by its imidazole side chain that can exist in three different states: two different neutral tautomeric forms and a protonated, positively charged one with a pKa value close to physiological pH. Commonly, two or all three states coexist and interchange rapidly, enabling histidine to act as both donor and acceptor of
Resistance to activated protein C (APC) is a major cause of familial thrombophilia, and can be corrected by an anticoagulant activity expressed by purified factor V. We investigated linkage between APC resistance and the factor V gene in a large kindred with familial thrombophilia. Restriction fragment length polymorphisms in exon 13 of the factor V gene were informative in 14 family members. The
Popular Abstract in Swedish Arbetet i denna avhandling har lett till en ökad förståelse av proteinet SOX11:as roll som biomarkör för äggstockscancer och B-cells-lymfom vilket förhoppningsvis kommer att resultera i enklare diagnos, bättre prognostik samt eventuellt nya terapier för dessa cancertyper. Var tredje person i Sverige beräknas få en cancerdiagnos någon gång i livet och statistiken är likIt is estimated that one third of all people in Sweden will be diagnosed with cancer during their lifetime. The outcome for a specific patient is related to early and correct diagnosis, and prediction of effective treatment regimens. Biomarkers are molecules that can aid the clinician in such decisions regarding diagnosis, prognosis and therapy. In this thesis, based on five original papers, the
Today, simulation of springback has still not reached enough accuracy for acceptance as a production tool in the automotive industry. Further investigations need to be done in order to understand how to improve the results in an efficient way. In order to investigate which parameters that are important for the accuracy in a springback simulation, a parameter study of a U-shaped rail was performed.
This paper presents a custom chip for linearization of RF power amplifiers using digital predistortion. The chip has been implemented in a standard digital 0.8 μm CMOS process with standard static cells and single-phase clocking. A systolic complex multiplier based on distributed arithmetic constitutes the core of the chip. The nonlinear function is realized with a look-up table containing complex
This paper presents a theoretical analysis of the neoliberal production of anxiety in academic faculty members in universities in Northern Europe. The paper focuses on neoliberalization as it is instantiated through audit and ranking systems designed to produce academia as a space of economic efficiency and intensifying competition. We suggest that powerful forms of competition and ranking of acad
Recent research has explored the potential of using the dynamic response of passing vehicles to conduct Structural Health Monitoring (SHM) efficiently. Various types of vehicles, including cars, vans, trucks, and even manually propelled carts, have been employed in this approach, with different configurations of exciters and receivers. A noteworthy development in this field involves the inclusion
Child first language acquisition (L1A) and adult second language acquisition (SLA) have observably different outcomes. Considering how distinct the two acquisition contexts often are, divergence is perhaps not surprising. Only adults acquiring a second language (L2) (i) are typically not surrounded by high quantities of native input, (ii) receive and must filter through significant amounts of non-
This study focuses on the influence of inhomogeneous corrosion on the quasi-static and cyclic properties of an Mg−Y−Nd alloy. Uniform corrosion is essential for biodegradable implant materials to avoid notching effects and premature failure. Previous studies on extruded Mg−3Y−3RE have shown a pitting tendency in Ringer’s solution at 37 °C. Tensile tests on pre-corroded samples with different corro
Protein tyrosine phosphatases (PTPs) play an important role in cellular signaling and have been implicated in human cancers, diabetes, and obesity. Despite shared catalytic mechanisms and transition states for the chemical steps of catalysis, catalytic rates within the PTP family vary over several orders of magnitude. These rate differences have been implied to arise from differing conformational
Do we owe anything to our genetic relatives qua genetic relatives? The philosophical literature has primarily addressed this question in the context of procreation. But genetic matching databases raise the question of whether we owe anything to previously unknown genetic relatives. This article argues that influential philosophical arguments regarding moral claims to know one’s genetic origins (so
There can be situations, for example if gas containers have been damaged in a vehicle crash, when the fire and rescue service would like to depressurize the gas containers through shooting with a civilian rifle. Modern high-pressure hydrogen containers are designed for a working pressure of 700 bars. This means that they have a very thick and strong shell made of composite material. At the same ti
BACKGROUND: To determine the association between cancer diagnosis and subsequent risk of ASCVD, and to examine the trajectory of the association over time after cancer diagnosis.METHODS: We prospectively followed 108,689 women in the Nurses' Health Study (NHS) (1984-2020), 113,569 women in the NHSII (1991-2019), and 45,328 men in the Health Professionals Follow-up Study (HPFS) (1986-2016) who were
This book uses a unique typology of ten core drivers of injustice to explore and question common assumptions around what urban sustainability means, how it can be implemented, and how it is manifested in or driven by urban interventions that hinge on claims of sustainability.Aligned with critical environmental justice studies, the book highlights the contradictions of urban sustainability in relat
Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl
Temperature is a crucial parameter of gas flow fields. Here, we present a novel thermometry technique for gas flow based on femtosecond laser-induced cyano (CN) luminescence. Specifically, a femtosecond laser with a central wavelength of 267 nm is used to induce CN violet emissions in a nitrogen flow seeded with a trace amount of methane. The spectral peak of CN B2Σ+- X2Σ+ (0,0) transitions shift
