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To date, there is no standard Verification and Validation (V&V) protocol for the evaluation of evacuation model predictions. This paper is intended to open a discussion on the main issues associated with the definition of a standard procedure for the V&V of building fire evacuation models. Examples of such issues are discussed, namely 1) the definition of tests able to investigate the capa

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews ha

I uppsatsen undersöker jag juridiska överväganden kopplade till balansen mellan en personlig assistents anställningsskydd och rätten till självbestämmande för assistansanvändaren, dvs. personen med funktionsnedsättning. Yrket som personlig assistent innebär ett nära samspel mellan assistansanvändaren och den personliga assistenten. I många fall är en hälsosam yrkesrelation en förutsättning för såvIn this thesis I examine legal considerations concerning the balance between employment protection for personal assistants and self-determination for the service user, i.e. the person with a disability. Personal assistance as a profession entails a close relationship between the service user and the personal assistant. In many cases, a healthy relationship is a condition for the wellbeing of the p

I analyse the effect of risk aversion on the share of wealth investment on risky tradable financial assets at individual level by exploiting the results of a laboratory experiment on a sample of over 700 Dutch respondents. The estimates of an econometric model show that for different wealth levels, risk aversion has heterogeneous effects on the share of wealth invested in risky tradable financial

The authors investigate how Third Mission activities at universities, such as the outreach and technology transfer functions, are anchored in organizational structures and practices, and discuss the implications of this relationship for the success of the activities. They draw on case studies of two Swedish university colleges to illustrate the diversity of mechanisms used to achieve Third Mission

Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. The main component identified in these protein-rich deposits is the p

The acoustic cavitation phenomenon is a source of energy for a wide range of applications such as sonoluminescence and sonochemistry. The behavior of a single bubble in liquids is an essential study for acoustic cavitation. The bubbles react with the pressure forces in liquids and reveal their full potential when periodically driven by acoustic waves. As a result of extreme compression of the bubb

This thesis is devoted to the study of different aspects of groups acting on rooted trees and their applications.First, we focus on the Hausdorff dimension of groups acting on rooted trees. We develop new tools that lead to the solution of several well-known open problems in the subject due to Abért-Virág, Bartholdi, Grigorchuk, Klopsch and Shalev among others.Secondly, we study many aspects of th

The overall aims of this thesis were to improve prediction, diagnostics and knowledge on epidemiology of sepsis. In paper I, we developed and evaluated an integrated platform for rapid analysis of sepsis-causing organisms directly from blood samples. Testing with blood samples spiked with bacteria and samples from septic patients indicate that the detection limit of the system is in the upper part

Based on multiphase field conception and integrated with the idea of vectorvalued phase field, a phase field model for typical allotropic transformation of solid solution is proposed. The model takes the non-uniform distribution of grain boundaries of parent phase and crystal orientation into account in proper way, as being illustrated by the simulation of austenite to ferrite transformation in lo

In a complex manufacturing system such as the multistage manufacturing system, maintaining the quality of the products becomes a challenging task. It is due to the interconnectivity and dependency of factors that can affect the final product. With the increasing availability of data, Machine Learning (ML) approaches are applied to assess and predict quality-related issues. In this paper, several M

BACKGROUND: The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC(TM) program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute

How we behave in daily life has an impact on environmental emergencies. In the decisions that we take every day, decisions that are important for the climate, the built environment has a vital but not so noticed part. The project Urban design and everyday life choices recognises the built environment as a co-producer of climate ethics. One of the project studies focuses on everyday choices regardi

β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the synthesis of two classes of glycosaminoglycans (GAG), i.e., heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS). GAG chains are linear polysaccharides of alternating hexuronic acid and N-acetylhexosamine residues, commonly linked to core proteins to form proteoglycans with important roles in the regulation of a range of biolo

What role should social science play in the work for transforming society towards sustainability? The background for this question is that despite massive investments in environmental research and the accumulation of data on the human impact on the environment, action remains insufficient. The severity of the current situation has led to the conclusion that moderate change is not enough; there is

Post hoc interventions rely on having access to certain personal data - such as the gender, age, ethnicity, and sexual orientation of the persons being evaluated - in order to detect and correct for prejudice. This brings these interventions into possible tension with pertinent data protection legislation, which might restrict the processing of said data. We discuss the compatibility of post hoc i

Exercise induced bronchial (EIB) constriction is a common and highly specific feature of pediatric asthma and should be diagnosed with an exercise challenge test (ECT). The impact of EIB in asthmatic children's daily lives is immense, considering the effects on both physical and psychosocial development. Monitoring childhood asthma by ECT's can provide insight into daily life disease burden and th