Filtyp
Rational, autonomous agents that are able to achieve their goals in dynamic, partially observable environments are the ultimate dream of Artificial Intelligence research since its beginning. The goal of this PhD thesis is to propose, develop and evaluate a framework well suited for creating intelligent agents that would be able to learn from experience, thus becoming more efficient at solving thei
A capillary filling microfluidic proteomic sample processing system has been realized in an automated set-up. Chip-integrated solid-phase extraction is performed in a 96-array format followed by sequential capillary action elution into a piezoelectric microdispenser and subsequent transfer to MALDI targets. Samples are eluted and deposited in volumes of 200–300 nl. The robotic system offers calibr
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit
Study commissioned by BIL Sweden for the Committee for Producer Responsibility Review (M 2000:01) på uppdrag av BIL Sweden
Many problems concerning resource management in modern communication systems can be simplified to queueing models under Markovian assumptions. The computation of the optimal policy is however often hindered by the curse of dimensionality especially for models that support multiple traffic or job classes. The research focus naturally turns to computationally efficient bounds and high performance he
Thread-Level Speculation can be used to take advantage of multicore architectures for web applications. We have implemented Thread-Level Speculation in the state-of-the-art JavaScript engine V8 instead of using an interpreted JavaScript engine. We evaluate the implementation with the Chromium web browser on 15 popular web applications for 2, 4, and 8 cores. The results show that it is beneficial t
Newton-Raphson and Goldschmidt algorithms can be sped up by using variable latency hardware architectures for rounding division, square root and their reciprocals. A new approach based on a rounding method with remainder estimate calculated concurrently with the algorithm was proposed in [5]. This paper presents an study of the hardware implementation of this approach and shows that does not suppo
Popular Abstract in Swedish Autoimmuna sjukdomar är tillstånd där vårt immunförsvar angriper den egna kroppen. Det finns ett flertal sådana sjukdomar av vilka jag huvud-sakligen har intresserat mig för rheumatoid artrit (RA) och multipel skleros (MS). De behandlingar som finns för de drabbade är idag främst riktade mot ergonomi, smärtlindring och olika former av immunsupres-sion (tex TNFa antikropThe causes of autoimmune diseases are largely unknown today, but there is evidence supporting a substantial complex genetic influence on many of these diseases as well as environmental factors and chance. In this thesis I have tried to get one step closer to the genetic causes of two autoimmune diseases through their induced counterparts in mice, namely rheumatoid arthritis (RA) and multiple scler
Denna avhandling handlar om teoretisk partikelfysik. Partikelfysik handlar om elementarpartiklar och hur dessa växelverkar med varandra, dvs vilka krafter som verkar mellan dem. Detta är hur materien ser ut på den minsta skala vi har kunnat studera experimentellt. Den teori som beskriver de starka, svaga och elektromagnetiska krafterna och de materiepartiklar som vi känner till, kvarkar och leptonThis thesis includes two topics.The first three papers is the major part of this thesis, which is about higher order calculations in the effective field theories of three QCD-like theories. These three QCD-like theories are distinguished by having quarks in a complex, real or pseudo-real representation of gauge group. We wrote their effective field theories in a very similar way so that the calcul
Theever-increasing test data volume for core-based system-on-chip(SOC) integrated circuits is resulting in high test times andexcessive tester memory requirements. To reduce both test time andtest data volume, we propose a technique for test-architectureoptimization and test scheduling that is based on core-levelexpansion of compressed test patterns. For each wrapped embeddedcore and its decompres
Popular Abstract in Swedish Forskning kring biomarkörer har revolutionerat cancersjukvården. Några av de mest kända exemplen är PSA-testet som kan användas för att identifiera patienter med ökad risk för prostata cancer eller de nya antikroppsbehandlingarna, t.ex mot HER2 (trastuzumab/Hercepin) eller CD20 (rituximab/Rituxan), som gör att man nu ofta kan förlänga eller bota patienter som tidigare hThe goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. The aim of this thesis is to
Abstract not available
We report on preliminary results from time-resolved optical spectroscopy of the He-rich variable white dwarf GD 358.
