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Background: Sjögren’s disease (SjD) is an autoimmune condition affecting exocrine glands, resulting in decreased saliva and tear production. Aquaporin 5 (AQP5) is a transmembrane water channel playing a central role in water transport. In SjD, deregulation of AQP5 expression, trafficking and interactions with various proteins contribute to the underlying disease mechanisms. Methods: Co-immunopreci
Long term economic growth leading to development is as much about growing as avoiding spells of considerable negative growth, or shrinking. However, much more attention has been given to understand what makes countries achieve high growth rates than to avoid shrinking. Here we explore empirically a novel approach which proposes that five interrelated dimensions of social capability (inclusion, tra
Background: Health system performance assessment helps identify areas for improvement and guides policy initiatives. Although well-validated indicators exist for measuring organ donation and transplantation performance at the facility level, consensus on indicators for assessing national programmes is lacking. The aim of this study was to develop a comprehensive scorecard for evaluating national o
Accumulation of acetate is a limiting factor in recombinant production of (R)-3-hydroxybutyrate (3HB) by Escherichia coli in high-cell-density processes. To alleviate this limitation, this study investigated two approaches: (i) deletion of phosphotransacetylase (pta), pyruvate oxidase (poxB), and/or the isocitrate lyase regulator (iclR), known to decrease acetate formation, on bioreactor cultivati
Chronic obstructive pulmonary disease (COPD) and asthma are heterogeneous respiratory diseases with overlapping symptoms but distinct underlying biology. As both diseases involve dysregulated inflammatory signalling, identifying disease- and compartment-specific pathways and biomarkers could improve diagnosis and treatment. A disintegrin and metalloproteinase 17 (ADAM17) is a key sheddase that inf
Introduction: Oesophageal resection carries significant morbidity and mortality. Artificial intelligence (AI) advances in medical research enable enhanced predictions, flexibility, and interpretability, especially for complex interactions and nonlinear relationships. Material and methods: We used a register-based case-control design nested within prospectively collected data from the Swedish Natio
The dynamics of ethanol production/consumption in baker's yeast were studied under feed- rate controlled conditions. The yeast was grown on molasses in an 8-l fed-batch reactor and experiments were done at cell concentrations between 5 and 65 g l−1. Small changes in the feed rate were made around a feed rate corresponding to the critical growth rate, at which the yeast cell metabolism switches bet
Objective: Varying degrees of inter-organizational collaboration concerning children at risk has grown rapidly since the 1980s. Collaboration is understood to provide a more holistic view of the child’s needs, lead to better care and treatment, more efficient law enforcement as well as increase knowledge in general. The aim of this presentation is to explore processes and effects, by highlighting
Using a system analysis approach compares different systems for handling and treatment of toilet waste and organic household waste. Design issues considered are source separation of urine, use of vacuum toilets and advanced nutrient recovery processes such as Reverse Osmosis (RO). All of the studied systems have low emissions of eutrophy ing compounds. Other environmental effects are mainly relate
The empirical part of this study is based on a survey of 600 Swedish households and a number of interviews where questions about residential energy behaviour and possible policy instruments for change were raised. The study provides insight into current behavioural patterns and gives a bottom-up perspective on the realistic perspective potentials for change and ways to achieve them. Residential en
Ectomycorrhiza (EM) is a symbiosis between soil living fungi and the roots of woody plants. EM fungal communities are important in forest nutrient cycling, they are species rich and their structures vary between habitats and over time. An EM community in a phosphorus-poor forest was exposed to apatite and EM mycelia actively colonizing ingrowth bags were analyzed. Internal transcribed spacer (ITS)
