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We have recently proposed a statistical AV node model defined by a set of parameters characterizing the arrival rate of atrial impulses, the probability of an impulse passing through the fast or the slow pathway, the refractory periods of the pathways, and the prolongation of refractory periods. All parameters are estimated from the RR interval series using maximum likelihood (ML) estimation, exce
Transposition of intestinal segments is frequently used for bladder reconstruction. Following transposition, bowel segments continue to produce mucus and a correlation between excessive mucus production and complications such as urinary tract infection or catheter blockage has been observed for a long time. However, no information is currently available on the change of mucin expression and glycos
Human carbonyl reductase 1 (CBR1), that is one of the enzymes responsible for the reduced efficiency of treatments by the antineoplastic agents anthracyclines, was functionally expressed in Saccharomyces cerevisiae. CBR1 was purified and kinetically characterised using daunorubicin as substrate. CBR1-catalysed reduction of daunorubicin followed an apparent Michaelis-Menten kinetics with K-M = 85.2
Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e
Mental illness has increasingly become a problem throughout the world and is believed to cost the global economy $16 trillion by 2030. Consequently, a growing body of literature investigates the possible causes of mental illness and more specifically, possible early life circumstances which may affect adult mental health. Limited research exists though in terms of exposure to recessions in utero a
Predictive archaeological modelling is a complex analytical process that requires the understanding of how complex environmental and anthropogenic spatial phenomena relate to the selection of archaeological site location and knowledge of the requirements and potential biases inherent in the method of modelling and the raw data itself. This paper aims to demonstrate the utility of the weights of ev
How can the low representation of women in politics in Bosnia-Herzegovina be understood and what can a different approach add to already existing approaches to make Bosnia-Herzegovina more gender equal in terms of political representation of the genders? There has been established a Gender Equality Law that demands a 40% gender quota of political representation, but the gender representation has o
Populärvetenskaplig sammanfattning: Hjälper Nhandugue-flodens vatten Urema-sjön i Gorongosa Nationalpark, Moçambique, från att torka ut? I de centrala delarna av Moçambique ligger Gorongosa Nationalpark som skyddar ett omfattande ekosystem av flodplan, gräsmarker och skogsbeklädda områden. Efter drygt 20 år av inbördeskrig hade 1994 antalet stora däggdjur, så som lejon, zebror och bufflar, minskatGorongosa National Park in central Mozambique is situated at the southernmost extension of the East African Rift System (EARS), the Urema Rift. The park is protecting a vast ecosystem of floodplains, grasslands and woody coverage. From 20 years of civil war the large-mammal population in the park had in year 1994 been reduced by 90 % or more, and in 2004 a restoration project was started in order
Popular science summary Identifying an African Paradise Flycatcher using molecular techniques Five species of Paradise Flycatchers (Terpsiphone) occur in mainland Africa. Colour polymorphism and hybridization in these birds make species identification and defining species boundaries challenging. A melanistic individual was captured in Gashaka-Gumti National Park in Nigeria, and could not be iden
This comparative document analysis looks at the governmentality of the Finnish labor market policies (LMP’s). This study compares Sipilä’s and Marin’s government programs to see if there are differences. The focus is on depicting neoliberalization and power relations in the policies while investigating the framing of unemployment. The theoretical framework consists of the theory of neoliberal turn
During the period 1905 to 1940 it was possible to get a loan from the state to buy land and build a small farm or a house in rural areas. This loan act and its effects have been studied earlier in different ways, but never as a total study for a geographic region. The region Malmöhus Län has been chosen. The purpose of this paper is to study in which parts of the area loans were taken and who sold
Abstract Title: Social services department’s modern centaurs – about social worker's dual role in cases of suspected crimes contribution Authors: Branislav Ros; Carl-Johan Martinsson Tutor: Lena Palvén Examiner: Elizabeth Martinell Barfoed The purpose of this study was to examine how social workers, in the social services department of economical aid, experience their dual role as helper
Objectives Early detection of neurosensory injury among workers exposed to hand-arm vibration is crucial. The aim of our study was to evaluate the diagnostic test performance of clinical point-of-care testing using a tuning fork and temperature rollers in relation to vibrotactile and thermal quantitative sensory testing. Methods We recruited 225 vibration-exposed workers who underwent clinical poi
Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator-like proteins 2 and 3 (NPRL2, and NPRL3) genes, which encode the components of GTPase activating protein Activity Toward Rags Complex 1 (GATOR1) complex. Evero
The sustainability transformation calls for policies that consider the global consequences of local lifestyles. We used stakeholders' visions of sustainable lifestyles across Europe to build 19 scenarios of sufficiency (net reductions) and 17 of green consumption (shift in consumption patterns). We applied Environmentally Extended Multi-Regional Input-Output analysis to model scenarios by assuming
Background: Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest which may pose therapeutic and prognostic challenges. To date, the only effective treatment for survivors of cardiac arrest is the insertion of an implantable cardioverter-defibrillator (ICD). We sought to review the long-term outcome of a Swedish cohort with IVF. Methods and results: Fifty patients with
Background: Glomerulonephritis clusters in families. However, infections are common inducers of glomerulonephritis and may also cluster in families. Studies of adoptees and their biological and adoptive parents may disentangle genetic from environmental causes of familial clustering. This is the first adoption study aimed to estimate the genetic contribution to the familial transmission of glomeru
Cerebral microbleeds (CMB) on MRI are frequent in healthy aging individuals but precede ischemic and hemorrhagic stroke and dementia. Different etiologies have been suggested for nonlobar CMB, which have a stronger connection to hypertension (HT) than do lobar CMB. This study aimed to investigate the prevalence of CMB and the association between nonlobar/lobar CMB and different blood pressure (BP)
Background Adverse events (AEs) or complications may arise secondary to the treatment of aneurysmal subarachnoid haemorrhage (SAH). The aim of this study was to identify AEs associated with microsurgical occlusion of ruptured aneurysms, as well as to analyse their risk factors and impact on functional outcome. Methods Patients with aneurysmal SAH admitted to the neurosurgical centres in Sweden wer
