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Between 1999 and 2005, 10 264 patients who had undergone total hip replacement (THR) for subcapital fracture of the hip were compared with 76 520 in whom THR had been performed for other reasons. All the cases were identified through the Swedish Hip Arthroplasty Register. The THRs performed as primary treatment for fracture were also compared with those done after failure of internal fixation. Aft
Proteome analysis involves many steps that generate large quantities of data in different formats. This creates a need for automatic data merging and extraction of important features from data. Furthermore, metadata need to be collected and reported to enable critical evaluation of results. Many data analysis tools are developed locally in research laboratories and are nontrivial to adapt for othe
BACKGROUND: Several surveys show that patients with chronic heart failure (CHF) are sub-optimally managed and treatment guidelines are not implemented in clinical practice. AIMS: To investigate awareness and perceptions of the 2005 European Society of Cardiology (ESC) guidelines for CHF. METHODS: 467 cardiologists from seven European countries completed an on-line interview using a validated, semi
Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global gene expression in human islets from 63 donors. Using 48 genes located near T2D risk variants, we identified gene coexpression and protein-protein interaction networks that were strongly associated with islet ins
As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake. Among healthy premenopausal non-hormone users, 3+ cups per day was associated with lower volume only in C-allele carriers (P(interaction)=0.02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer.British Journal o
Dermatan sulfate is a highly sulfated polysaccharide and has a variety of biological functions in development and disease. Iduronic acid domains in dermatan sulfate, which are formed by the action of two DS-epimerases, have a key role in mediating these functions. We have identified the catalytic site and three putative catalytic residues in DS-epimerase 1, His205, Tyr261 and His450, by tertiary s
A newly developed aluminium-polymer-laminated steel reflector for use in solar concentrators was evaluated with respect to its optical properties, durability, and reflector performance in solar thermal and photovoltaic systems. The optical properties of the reflector material were investigated using spectrophotometer and scatterometry. The durability of the reflector was tested in a climatic test
Background People applying for a housing adaptation (HA) grant are at great risk of participation restrictions due to declining capacity and environmental barriers. Aim To investigate the association of person-, environment-, and activity-related factors with participation frequency and satisfaction among people applying for a housing adaptation grant. Material and methods Baseline cross-sectional
The main purpose of this study was to investigate whether the outcome obtained at the end of a work rehabilitation programme for people with various disabilities were stable in a one-year perspective. An additional aim was to explore which factors influenced the outcome upon completion of work rehabilitation and at the one-year follow-up. The study used information from a database and comprised 29
Design science research involves creating and evaluating innovative methods and approaches to be used in design practice. We present an approach to be used in the process of designing Management Support Systems (MSS). The nature of managerial work makes the design, development, and implementation of MSS a major challenge. The MSS literature suggests that determining MSS requirements and specificat
With diversified requirements and varying manufacturing environments, the optimal production planning encountered in a steel mill became more flexible and also complicated. The flexibility can provide the operators with auxiliary requirements through an implementable integrated production planning. In this paper, a mixed-integer nonlinear programming (MINLP) model is formulated for the optimal pla
Food retailers might foster consumption of sustainable products by influencing both demand and supply-side characteristics, as they represent the main marketing channel of food products in most of European countries. However, only few European retailers are actively engaged in activities of sourcing and promoting more sustainable products, with current share of sustainable food in the retail assor
An increasing demand on load flexibility in power supply networks is the motivation to look at flexible, and possibly optimal control systems for power plants with carbon capture units. Minimizing the energy demand for carbon dioxide removal under these circumstances reduces the cost disadvantage of carbon capture compared to conventional production. In this work a dynamic model in Modelica of a c
