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AXL, a member of the TAM family, is a promising therapeutic target due to its elevated expression in advanced hepatocellular carcinoma (HCC), particularly in association with acquired drug resistance. Previously, RNA interference was used to study its role in cancer, and several phenotypic changes, including attenuated cell proliferation and decreased migration and invasion, have been reported. Th
Evaluating the structure of soil prior to building construction is valuable in a large variety of geotechnical and civil engineering applications. To built an effective framework for assessing the strength of the stabilised soil, the presented workflow includes a complex approach of simplex lattice design and X-ray diffraction for the analysis of soil structure. Different from the traditional in s
Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for athe
The late Cambrian Steptoean positive carbon isotope excursion (SPICE) represents a major perturbation to the global carbon cycle and was associated with trilobite extinctions and expansion of anoxic and/or euxinic water masses during episodes of eustatic sea-level change. We present a new Re-Os age together with Os and Nd isotope stratigraphy and major and trace-element data from the Alum Shale Fo
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms and cellular affectation, making their study complicated due to the lack of proper animal models that fully mimic human diseases and the poor availability of post-mortem human brain tissue. Adult human nervous tissue culture offers the possibility to study different aspects of neurological disorders. Molecular, cel
A fundamental problem in radiotherapy is the variation of organ at risk (OAR) volumes. Here we present our initial experience in engaging a large Radiation Oncology (RO) community to agree on national guidelines for OAR delineations. Our project builds on associated standardization initiatives and invites professionals from all radiotherapy departments nationwide. Presently, one guideline (rectum)
Background - Comorbidity between psychiatric disorders is extensive but, from a genetic perspective, still poorly understood. Modern molecular genetic approaches to this problem are limited by a reliance on case-control designs. Methods - In 5 828 760 individuals born in Sweden from 1932-1995 with a mean (s.d.) age at follow-up of 54.4 (18.1), we examined family genetic risk score (FGRS) profiles
This article concerns a field study about the use of non-invasive manual lighting and shading control to save energy in listed buildings. The system was chosen to limit cabling and masonry work. The test room consists of an individual office located in a historical building in Southern Italy. The room was retrofitted with two roller shades (semi-transparent and blackout) and six LED-based pendants
Children's participation in economic activities has been documented as an inseparable part of the family support network in childhood studies. Children as an integral part of the parents' world contribute to enhanced social experiences, the continuity of the societal system, and the holistic well-being of the family. In the pro- baby global south children are political, economic, cultural, and soc
In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanoc
Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t
School-related functional impairment is common in children and adolescents with obsessive-compulsive disorder (OCD). However, little is known about the characteristics of youth with OCD who struggle in school, whether these struggles interfere with treatment outcomes, and whether treatment improves school-related function. Among 385 youth with OCD at a specialist clinic (mean age [sd] = 13.7 [2.5]
Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT phenotype. Furthermore, HNF4A down-regulation has been observed following kidney injury in mouse models. The aim of the present work was to investigate the role of HNF4A during acute and
The occurrence of climate change will have a significant impact on society and adapting to a more sustainable environment is of key importance. The dangers of climate change will include temperature and precipitation patterns becoming more extreme creating a substantial impact on society. Greece’s location and climate make it particularly vulnerable to a changing climate and climate impact assessm
This study aims to examine how the sensitivity for macroeconomic announcements surprises changes for the exchange rate in terms of a crisis. Previous research has been biased for U.S announcements and their relation towards emerging market, which has shown that U.S announcements affect more than the domestic. It also suggests that business cycle and uncertainty affect and increase the reaction for
Statsansvaret för folkmord har en jus cogens status i internationell sedvanerätt och utgår från den generella hänförbarhetsregeln: huruvida de inom staten aktiva personer eller grupper är verksamma, eller åtminstone kan anses vara verksamma å statens vägnar är avgörande för att staten kan hållas ansvarig. För att icke-statliga aktörer kan vara hänförliga till staten måste förhållandet dem emellan State responsibility for commission of genocide has a jus cogens status in customary international law and is based on the general rule of attribution: whether the persons or groups acting within the State are acting, or at least can be treated as acting on behalf of the State is key for State responsibility to arise. For non-state actors to be attributable to the State the relationship between th
This study explores the Chinese computational propaganda exploitation during the Covid-19 crisis. By demonstrating the intricacies of this case of computational propaganda utilization, this research attempts to answer an even larger question: How do authoritarian countries incorporate computational propaganda to their soft power strategies. To that end, first; a theoretical bridge was formed betwe
Coastal floodplains are at risk for combined high discharge and sea level events. Consequences when they occur can be several magnitudes greater than the impact from any isolated event. In this thesis the compounding of different river and coastal flood combinations at three case study sites were studied through the use of 1D/2D-hydraulic modelling software LISFLOOD- FP. The areas were; Henån, Äng
While carbon emissions hit an all-time high in 2019 and are expected to grow, it is important to explore strategies for reducing emissions and mitigating climate change. A potential focus for curbing emissions is the flying sector, since air travel is one of the most carbon-intensive activities an individual can engage in. Among air travelers, frequent flyers yield the highest potential for saving
Japan currently faces a rapid increase in labor immigrants due to the decrease of the population. The number of immigrant children is expected to increase because of the open labor immigration policy. Although the education of immigrant children is very complex, Hamamatsu city and Kani city have implemented successful educational policies to solve the problems of out-of-school children. This resea
