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Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged
Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.
Objectives To examine whether multimorbidity aggregates in families in Sweden.Design National explorative family study.Setting Swedish Multigeneration Register linked to the National Patient Register, 1997-2015. Multimorbidity was assessed with a modified counting method of 45 chronic non-communicable diseases according to ICD-10 (international classification of diseases, 10th revision) diagnoses.
Risk assessment of pesticide impacts on remote ecosystems makes use of model-estimated degradation in air. Recent studies suggest these degradation rates to be overestimated, questioning current pesticide regulation. Here, we investigated the concentrations of 76 pesticides in Europe at 29 rural, coastal, mountain, and polar sites during the agricultural application season. Overall, 58 pesticides
This paper aims to identify micro-level processes shaping the narratives surrounding regional opportunity spaces. A process perspective is applied to examine how place leaders engage in shaping narratives to influence the perception of opportunity spaces. The empirical research is based on a comparative case study of four peripheral regions in Germany, comprising 92 interviews with regional stakeh
Ambient fine particulate matter PM2.5 (particles with a diameter smaller than 2.5 μm) has been associated with cardiovascular and respiratory morbidity and mortality. It has been shown that biomass burning for heat production purposes can generate large amounts of fine particles. Thus characteristics of particle emissions from biofuel combustion may be important in the assessment of health effects
Popular Abstract in Swedish I denna avhandling studeras ledningsförmågan hos nanometer-stora kvantprickar tillverkade i halvledarmaterial. Halvledare är material vars ledningsförmåga ligger någonstans mellan ledare (metaller) och isolatorer. I halvledare kan ledningsförmågan ändras med elektriska fält, vilket har möjliggjort utvecklandet av halvledartransistorn. Utvecklandet av halvledartransistorThis thesis focuses on electron transport in single and double quantum dots defined in low-dimensional, narrow-band-gap III-V semiconductor materials. Fabrication schemes are presented for defining single and double quantum dots in lateral InGaAs/InP heterostructures, either by a combination of etching and local gating or solely by local top gating. The quantum dots are here electrostatically conf
Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the
We still have limited knowledge about the underlying genetic mechanisms that enable migrating species of birds to navigate the globe. Here we make an attempt to get insight into the genetic architecture controlling this complex innate behaviour. We contrast the gene expression profiles of two closely related songbird subspecies with divergent migratory phenotypes. In addition to comparing differen
Nanoimprint lithography (NIL) is a nonconventional lithographic technique that promises low-cost, high-throughput patterning of structures with sub-10 nm resolution. Contamination of nanoimprint stamps is one of the key obstacles to industrialize the NIL technology. Here, we report two efficient approaches for removal of typical contamination of particles and residual resist from stamps: thermal a
Background: The aim of this study is to estimate ovarian volume, number and volume of antral follicles, and ovarian power Doppler vascular indices as assessed by three-dimensional (3D) transvaginal grayscale and power Doppler ultrasound in women using combined oral contraceptives (COC). Study Design: Two hundred thirteen gynecologically asymptomatic women 20-39 years old using COC were examined wi
There is increasing evidence that short-chain fatty acids (SCFA) formed by colonic fermentation of indigestible carbohydrates have beneficial physiological effects. Butyric acid is the main energy substrate for the colonic mucosa and has been implicated as important in the prevention and treatment of diseases of the colonic mucosa, such as distal ulcerative colitis and cancer. Propionic acid, on t
Background: Sandvik is in the middle of a great investment, the so called Green Field investment, which will imply a new factory for parts of their stone crush production. The facility is, at current situation, in engineering phase and the preparations are in focus and running at high speed. Purpose: The aim of this master thesis and final course in the education is to give an insight and valuable
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.METHODS: For countri
The exhaustion doctrine (also known in some jurisdictions as the ''first sale doctrine See U.S. Copyright Code Section 109(a)'') is one of the basic rules of intellectual property (IP) system, and is applied to many IP rights, from copyright to trademark. The term ''exhaustion'' or ''first sale'' describes the concept of this rule, where, after the &
Vid en diskussion om nivån på den svenska bolagsskatten är det av stor vikt att avgöra huruvida diskussionen rör den nominella eller den effektiva skattesatsen. Den nominella skattesatsen uppgår till 28 procent och återfinns i 65 kap. 14 § IL. Den effektiva skattesatsen är däremot inte given utan kan i viss utsträckning påverkas, eftersom den bestäms genom att dividera skatt på årets resultat med
Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the
Background: The optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. We aimed to estimate the effects of starting a direct oral anticoagulant (DOAC) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke. Methods: For this systematic review and meta-analysis we sea
Salinity gradient energy (SGE) can play an important role in the energy transition from fossil-based sources to renewable sources. Its potential is estimated to be around 625 TWh·a-1 corresponding to 3% of global electricity consumption [1]. SGE sources are most abundant in the estuaries where rivers meet seawater. However, it is also available in different forms such as brackish water, brine etc
The twin transition, which combines green and digital innovation in economic activities, is increasingly central to policy agendas and is also receiving growing attention in regional research. However, accurately mapping green, digital and twin (both green and digital) economic activities across regions remains challenging, particularly due to data constraints. In this study, we advance this resea
