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Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th
Background. Ruling out acute myocardial infarction (AMI) in the emergency department (ED) is challenging. Studies have shown that a high-sensitivity cardiac troponin T (hs-cTnT) <5 ng/L or <6 ng/L at presentation (0 h) can be used to rule out AMI. The objective of this study was to identify whether an even higher hs-cTnT threshold can be used for a safe rule out of AMI in the ED. Methods. The deri
We study experimentally and with wave optics modelling the absorption of light in CsPbBr3perovskite nanowire arrays fabricated into periodic pores of an anodized aluminum oxide matrix, for nanowire diameters from 30 to 360 nm. First, we find that all the light that couples into the array can be absorbed by the nanowires at sufficient nanowire length. This behavior is in strong contrast to the expe
Boilerplate är en term som används för att beskriva standardiserade klausuler som ofta återfinns i slutet av ett avtal och som behandlar generella frågor som inte är beroende av avtalets art eller omfattning. Det finns flertalet olika boilerplate, varav en är integrationsklausulen. Klausulen har i och med internationaliseringen av den kommersiella rätten blivit mycket vanligt förekommande i svenskBoilerplate is a term used to describe standardized clauses that often appear at the end of a contract and deals with general issues that are not dependent on the nature or scope of the agreement. There are several different boilerplates, one of which is the entire agreement clause. The entire agreement clause has become very common in Swedish law due to the internationalization of Swedish busines
Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1
Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh
Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of
LUNDS UNIVERSITET ht 2015 HISTORISKA INSTITUTIONEN HISS14 temakurs avancerad nivå 7,5 hp Harald Gustafsson Plats, rum, landskap Spatiala perspektiv i historisk forskning Information, schema, litteraturlista m.m. Kursinformation Hej och välkomna till en kurs som förhoppningsvis öppnar nya landskap och tar oss till spännande platser! Plats är ett begrepp som har börjat ta allt större plats hos histo
https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISS14/20152/ht_15_plats_infopaket.docx - 2026-07-21
Here we report the results from exploratory analysis using a Bayesian network approach of data originally derived from a large North European study of type 2 diabetes (T2D) conducted by the IMI DIRECT consortium. 3029 individuals (795 with T2D and 2234 without) within 7 different study centres provided data comprising genotypes, proteins, metabolites, gene expression measurements and many differen
The long-standing debate in the scientific community about whether ferroelectricity or ferroelasticity is the key property influencing the optoelectronic behavior of metal halide perovskites continues. In this study, we experimentally investigate the temperature dependence of photoluminescence from CsPb(Br1−xClx)3 nanowires and their heterojunctions. Our findings show an enhancement of the exciton
Över 80 000 personer bor på särskilt boende i Sverige. Flytten dit är ofta livets sista och kan medföra psykisk och fysisk påfrestning med risk för depression, försämrad hälsa och för tidig död. Endast personer med omfattande hjälpbehov beviljas plats, och enligt lag får flytten inte ske mot den äldres vilja. Trots ökad skörhet förväntas individen alltså själv ta stort ansvar för flyttprocessen. DMore than 80,000 people live in nursing homes in Sweden. The move isoften the final relocation in life and may involve both psychological andphysical strain, with risks of depression, deteriorating health, and prematuredeath. Only individuals with extensive care needs are granted placement,and by law, the move cannot be made against the will of the older person.Despite increased frailty, individua
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
Background: While housing and neighborhood features have the potential to impact opportunities for active aging, there is a lack of knowledge related to how older people reason regarding their housing situation and how housing and fulfillment of relocation are associated with active and healthy aging. Objective: The objectives of Prospective RELOC-AGE are to study housing choices and relocation an
SUMMARYHigh prenatal detection rates of complex congenital heart defects (CHD) Aim: To analyze prenatal detection rates of complex CHD after the implementation of an expanded three-tiered screening model at the Skane University Hospitals in Lund and Malmö in 2015. Methods: Retrospective review of pregnancies screened from January 1, 2015 and being born by June 30, 2018. Complex CHD was defined as
Uncertainty refers to any limitation in knowledge. Identifying and characterizing uncertainty in conclusions is important to ensure transparency and avoid over or under confidence in scientific assessments. Quantitative expressions of uncertainty are less ambiguous compared to uncertainty expressed qualitatively, or not at all. Subjective probability is an example of a quantitative expression of e
Objective: To assess whether adding prostate volume to the kallikrein panel improves discrimination for ISUP Grade Group 2 or higher (GG2+) disease, as some men may have volume measurements available at the time of blood draw. While prostate volume predicts biopsy outcome, it requires an imaging procedure for measurement. The four kallikrein panel - commercially available as the 4Kscore - predicts
This document presents design considerations of a sample for accelerated thermal aging tests. The proposed specimen is a parallel wired solenoid that is evaluated by using an axi-symmetric 2D finite element (FE) model in Comsol multi-physics. The aim of the design model is visualizing an interior stress distribution of an idealized coil in order to interpret the physics-of-failure in a more comple
Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T c
BACKGROUND: The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in
