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This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive
Popular Abstract in Swedish När patienten lämnar sjukhuset och återvänder hem efter en operation för kolorektal cancer (tjocktarm och ändtarm) innebär det en stor omställning. De är inte återställda efter den stora bukoperationen och upplever olika symtom som smärta, tarmbesvär och stor trötthet. Eftersom vårdtiderna blir allt kortare har deras återhämtning bara påbörjats på sjukhuset och de kommeThe overall aim of this thesis is to study the experiences of patients and next of kin with regard to information and information needs after being discharged after colorectal cancer surgery. The aim was also to study factors related to this. Different methods were combined in this explorative study in order to obtain diverse types of data. Patients who had undergone surgery for colorectal cancer
The increase and range extension of wolves (Canis lupus L) and brown bears ( Ursus arctos L) in Scandinavia inevitably impacts moose (Alces alces L.) populations and, as a consequence, the size and composition of the hunter harvest must be adjusted. We used a sex- and age-structured moose population model to delineate optimal harvest strategies under predation and to compare the resulting harvest
Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to
This thesis covers dismissal due to the employee's underachievement. The 7 § of the Swedish Employment Protection Act states that there must be just cause for dismissal. There are two different situations that classify as just cause for dismissal&semic shortage of work or reasons related to the individual employee concerned. Underachievement falls within the latter. The circumstances under
Europe, following the American model, became a Car Society during the Golden Age. In Sweden, mass-motorization spread faster and approximately ten years earlier than in the rest of the continent. This study aims to pinpoint factors explaining this advance. In general, living standards are considered as the determinant of private car diffusion; population dispersion is also assumed to be an acceler
This dissertation is about the antagonistic conceptions of men’s violence against women – rape, incest and physical assault – as has been expressed by different actors in Sweden from 1975 – 2000. Mainly, my interest lies in how and why these conceptions have been articulated. During the studied period the attention to men’s violence against women as a question of gender, has grown remarkably. For
The project was performed for FAS Converting Machinery AB (FAS) in Ystad with supervision from Industriell Elektroteknik och Automation at LTH. FAS is a company that makes machines for producing plastic bags on a roll. The problem given was to develop a sensor for detecting the perforations in the bags to ensure that the correct amount of bags was rolled up and that the tearing was in the right pl
Background: Knee pain is studied mostly in older age groups, although in young adults it may be an indicator of future impaired musculoskeletal health. Therefore, the aim of this study was to examine the longitudinal association between knee pain and thigh muscle strength in young adult women and to explore the associations between muscle strength, body composition, physical activity and knee pain
Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload. Methods and materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC
Metalloenzymes are proteins that contain one or more metal ions bound to protein. They constitute about one-third of all enzymes known so far and they often perform hard chemical reactions involving small substrates, like H2 and N2. In our research, we focus on those metal ions that are located in the active sites and perform redox reactions, i.e. involving electron transfer. Why enzymes?Metalloenzymes catalyse a wide variety of reactions in nature. In the thesis, I have studied the reaction mechanism of three metalloenzymes, viz. [NiFe] hydrogenase (H2ase), dimethyl sulfoxide reductase (DMSOR) and formate dehydrogenase (FDH), by theoretical methods, namely quantum mechanics (QM), combined quantum mechanical and molecular mechanics (QM/MM), as well as QM/MM thermodynamic cycle per
Navigation is the ability of animals to move through their environment in a planned manner. Different from directed but reflex-driven movements, it involves the comparison of the animal’s current heading with its intended heading (i.e., the goal direction). When the two angles don’t match, a compensatory steering movement must be initiated. This basic scenario can be described as an elementary nav
We examine strategic self-ignorance—the use of ignorance as an excuse to over-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts of such activities. We then confront our model with data from an experiment using prepared, restauran
Problemformulering: Vilka åtgärder kan vidtas för att bemöta de utvecklingsbehov Miljöbyggnad står inför gällande betygssystemets och ingående indikatorers utformning? Syfte: Syftet är att i första hand utvärdera betygssättningssystemet i Miljöbyggnad. I andra hand ska förbättrande åtgärder utarbetas och provas. Arbetet ska avse vara en del i underlaget inför utvecklingen av systemet. SlutsatserThe Issue/problem: What measures can be taken to address the development needs Miljöbyggnad are facing regarding its rating system and detailed design of indicators? The Purpose: The purpose is primarily to evaluate the rating system in Miljöbyggnad. Secondly, improvement measures will be developed and tested. The work will relate to being part of the basis for the development of the system. The
This thesis explores how urban renewal, and the subsequent gentrification implicit in this process, alters and affects queer experiences of spaces in twenty-first century London. First, the reasons queer people move to cities are discussed using Sara Ahmed’s term orientation.To highlight the socio-political importance of queer landmarks and locales, an investigation of Shoreditch, east London is u
The purpose of the project has been to investigate how people dwell and furnish in recently build apartments. The project consists of a dwelling survey where 14 tenants in four different types of apartments, architects, realtors and an availability expert are interviewed to give their view on how Swedish regulations regarding housing corresponds to how people live, and want to live. The project co
This paper conducts an empirical study on the relationship between the emerging financial market of China and the developed market of the US, both during and after the 2007-2009 financial crisis. Stock indices from the two countries are analysed to examine whether there exist any comovements between the different equity markets. Econometric time series testing of weekly stock values indicate that
År 2021 reformerades lagstiftningen gällande barns rätt att komma till tals i frågor om vårdnad, boende och umgänge. I 6 kap. föräldrabalken tillkom 2 b § som stadgar att barnet ska få information och ges möjlighet att framföra sina åsikter i frågor om vårdnad, boende och umgänge. Barnets åsikter ska tillmätas betydelse i förhållande till barnets ålder och mognad. Detta är den rättsliga utgångspun
