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Increased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs). Previous studies have associated enhanced complement activation with increased disease severity. Additionally, treatment refractoriness has been deIncreased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs). Previous studies have associated enhanced complement activation with increased disease severity. Additionally, treatment refractoriness has been de

All five Nordic countries emphasize equal and easy access to healthcare, assuming that increased access to healthcare leads to increased health. It is the purpose of the present study to explore to which extent the populations of these countries have reached good health and a high degree of socio-economic equality in health. Each of the five countries has established extensive public health progra

Context. It has recently been suggested that all giant stars with masses below 2 M? suffer an episode of surface lithium enrichment between the tip of the red giant branch (RGB) and the red clump (RC). Aims. We test if the above result can be confirmed in a sample of RC and RGB stars that are members of open clusters. Methods. We discuss Li abundances in six open clusters with ages between 1.5 and

This study evaluates the practice of the security provisions in ADR (the Agreement concerning the International Carriage of Dangerous Goods by Road) for the first time. A qualitative case study of an organisational field was undertaken, comprising fourteen semi-structured interviews with four government agencies and eight logistics firms in transportation of dangerous goods in Sweden. Four evaluatThis study evaluates the practice of the security provisions in ADR (the Agreement concerning the International Carriage of Dangerous Goods by Road) for the first time. A qualitative case study of an organisational field was undertaken, comprising fourteen semi-structured interviews with four government agencies and eight logistics firms in transportation of dangerous goods in Sweden. Four evaluat

This article investigates the emergence and early use of possessive havegot in English. Two hypotheses about its emergence are tested on historical data (c.1460–1760). One hypothesis is based on communicative functionality, suggesting that got was inserted as a ‘pattern preserver’ to compensate for the increased reduction of have. The other hypothesis invokes the conventionalization of an invited

For the juice package to protect and keep your juice fresh it is important that the different layers in the packaging material sticks very well together. The ability for two things to stick together is called adhesion. For the people that create juice packages, this is important to measure so that the packages don’t leak. This measurement has turned out to be very tricky, but this study has shown

The Sugar Experiments In 1942, 99.99 percent of the Swedish population had dental caries. Public Dental Health Care system, which had only been established in 1938, was struggling to cope with the task of providing care to all. The solution proposed by the Swedish Government was research. This thesis examines a medical experiment on the interface between medical science, public health policy, men

A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha(ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele f

Pressure on reducing prices and a market demand for customisation and shorter production runs give cause for investigating alternatives to conventional printing. Traditional technologies, such as flexography and offset, are all using static printing forms, while a digital printing unit prints information directly from the data file. Hence, the latter alternative makes it possible to produce short

Low molecular weight protein tyrosine phosphatase (LMW-PTP) dimerizes in the phosphate-bound state in solution with a dissociation constant of K-d = 1.5(+/-0.1) mM and an off-rate on the order of 10(4) s(-1).H-1 and N-15 NMR chemical shifts identify the dimer interface, which is in excellent agreement with that observed in the crystal structure of the dimeric S19A mutant. Two tyrosine residues of

Popular Abstract in Swedish Modelleringsarbetet utvecklat i denna avhandling, kan delas in i två huvudområden: självantändning i ottomotorer, samt förbränning och emissioner i dieselmotorer. En första version av ett motorsimuleringsprogram med detaljerad kemisk kinetik, utökad för att innefatta full-cykel beräkningar, användes för att visa den starka påverkan som kväveoxider i restgaser har på sjThe modeling work developed in this thesis can be divided in two main areas of investigations: autoignition related to spark ignition engine and combustion and emissions formation in relation to diesel engines. A first version of a detailed kinetics engine simulation program, extended to handle full cycle calculations, was employed in order to demonstrate the strong effect that nitric oxide from

Linear multistep methods (LMMs) constitute a class of time-stepping methods for the solution of initial value ODEs; the most well-known methods of this class are the Adams methods (AMs) and the backward differentiation formulae (BDFs). For the fixed stepsize LMMs there exists an extensive error and stability analysis; in practical computations, however, one always uses a variable stepsize. It is w

In previous years, substantial research has focused on walkability, primarily examining how the built environment affects walking behavior. However, these studies have predominantly defined walkability through physical and social factors, with limited exploration of its spatial dimension. This article seeks to address this gap by examining the spatiality of walkability through Lefebvre’s spatial tIn previous years, substantial research has focused on walkability, primarily examining how the built environment affects walking behavior. However, these studies have predominantly defined walkability through physical and social factors, with limited exploration of its spatial dimension. This article seeks to address this gap by examining the spatiality of walkability through Lefebvre’s spatial t

The idea of a Nordic community, even though it was a reality in the past and is still a quite tangible idea in the present – because all Nordic countries have striking similarities – is often obscured by the more recent idea that the nation always comes first, and for quite some time now the Nordic countries have been anxious to set themselves apart from their closest neighbour in particular.In th

Extending beyond previous research biases towards large cities or analyses based largely on one type of urban agriculture (UA) (such as market gardening, or home gardening), this research aimed to investigate all forms of UA within two intermediate-sized Ghanaian cities (Techiman and Tamale). Where was being farmed? For whom, and why? The paper considers how findings compare to Ghana's larger citi

Many patients with Parkinson's disease (PD) experiencing L-DOPA-induced dyskinesia (LID) receive adjunct treatment with dopamine agonists, whose functional impact on LID is unknown. We set out to compare temporal and topographic profiles of abnormal involuntary movements (AIMs) after L-DOPA dose challenges including or not the dopamine agonist ropinirole. Twenty-five patients with PD and a history

Background & Aims: RNA interference (RNAi) may offer new treatment options for chronic hepatitis B. Replicating via an RNA intermediate, hepatitis B virus (HBV) is known to be principally vulnerable to RNAi. However, beyond delivery, the relevant issues of potential off-target effects, target site conservation in circulating HBV strains, and efficacy of RNAi itself have not systematically been

A trade-off between survival to sexual maturity and mating success is common across alternative reproductive tactics (ARTs), and can lead to tactical disruptive selection on shared traits (i.e. positive selection gradient in one tactic, and negative selection gradient in another). We were interested in examining the theoretical possibility of tactical disruptive selection on intrinsic growth rate.