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Objectives: Decision-analytic models assessing the value of emerging Alzheimer's disease (AD) treatments are challenged by limited evidence on short-term trial outcomes and uncertainty in extrapolating long-term patient-relevant outcomes. To improve understanding and foster transparency and credibility in modeling methods, we cross-compared AD decision models in a hypothetical context of disease-m
Background: Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been linked. Method: Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized to postnatal enteral AA/DHA supplementation or standard care (contro
Background: Although glomerular diseases are the third most frequent cause of end-stage kidney disease worldwide, little is known about their long-term outcomes. Methods: In patients with chronic kidney disease (CKD) stage 3–5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four mos
BACKGROUND AND PURPOSE: Adaptive radiotherapy (ART) involves treatment re-planning based on anatomical changes, which may improve target coverage and sparing of organs-at-risk (OARs). This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC).MAT
AIMS: To evaluate the long-term clinical and economic outcomes associated with insulin detemir and neutral protamine hagedorn (NPH) insulin in combination with mealtime insulin aspart in patients with type 1 diabetes in Sweden, based on data from a two-year, multi-national, open-label, randomized, controlled trial.METHODS: Insulin detemir was associated with significant improvements in glycaemic c
Background/Objectives: The surgeon’s subjective intraoperative evaluation is the standard of care to assess postoperative residual disease (RD) in advanced epithelial ovarian cancer (EOC). We investigated the feasibility of ctDNA as an objective marker for postoperative RD. Methods: This prospective study included 27 patients with advanced ovarian cancer (FIGO IIIA1–IVB) who underwent primary surg
BACKGROUND: The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.OBJECTIVE: This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.METHODS: This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1-FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Clinical data on FPDMM-associated AML (FPDMM-AML) are limited, complicating evidence
Background and Objectives: Temporomandibular disorders (TMDs) is an umbrella term for pain and dysfunction involving jaw muscles and/or the temporomandibular joint, with whiplash trauma suggested to be one risk factor. The aim was to evaluate prevalence and relative risk of TMDs in the acute and chronic stages after whiplash trauma. Databases and Data Treatment: This review was registered in Prosp
Drought is a climate risk that affects access to safe water, crop development, ecological stability, and food production. Therefore, developing drought prediction methods can lead to better management of surface and groundwater resources. Similarly, machine learning can be used to find improved relationships between nonlinear variables in complex systems. Initially, the standardized precipitation
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, the formation of vesicles during the preparation of cubosomes, and the presence of mixed bicontinuous cubic phases, may lead to artifacts and lack of correlation between the physico-chemical and biological characterization. In this work, we h
By assessing carbon footprints and raising awareness of carbon labelling, the food sector is setting long-term targets to reduce carbon emissions and accelerate the transition to low-carbon food production. Carbon labelling, also known as carbon labelling, informs customers about a product's production, distribution, and disposal carbon emissions. This study examines how customers view carbon labe
Urban pluvial flooding threatens transport accessibility, yet the spatial factors such as elevation, vegetation, and road density associated with accessibility loss remain insufficiently understood. This study assessed changes in nearest-facility travel time to hospitals, clinics, schools, supermarkets, and fire stations under a 100-year return period flood scenario in Stockholm, Sweden, for both
Purpose: Right ventricular (RV) dysfunction is the key prognostic factor in pulmonary arterial hypertension (PAH). Progression to RV failure involves dilatation, systolic and diastolic impairment, fibrosis, and metabolic changes. Lung transplantation (LTx) normalizes RV afterload, but the extent of recovery and its relation to immunosuppressive therapy remain unclear. We aimed to assess RV functio
Background: Cardiac allograft vasculopathy (CAV) is one of the major long-term complications in patients after heart transplantation (HTx) limiting allograft function and longevity. CAV can be studied non-invasively by evaluating myocardial perfusion (MP). Aspirin is re--ed after Htx, but it is unclear whether it affects the development of CAV. The aim of this study was to investigate the associat
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies wit
BACKGROUND: Diabetes mellitus and hypertension are risk factors for cardiovascular disease, which is the most common cause of death in the world. People with intellectual disability (ID) have been reported to have high rates of both these disorders. The aim of this study was to describe and compare prevalence ratios of diabetes mellitus and hypertension between older adults with ID and their age p
Background: Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age. Method: Eight-year-old children who had participated in a vitamin D intervention project when they were 6 years old wer
Purpose: Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation ex
The Child Eating Behaviour Questionnaire (CEBQ) is a well-established instrument in the study of obesity-related eating behaviours among children. However, research using the CEBQ in multicultural samples is limited. This study aims to identify and examine differences in child eating behaviours as reported by Swedish-born and non-Swedish-born mothers living in Sweden. Mothers (n = 1310, 74 countri
