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Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V-H genes. We also reported restricted use of certain V-H genes. To assess the prognostic impact of these new findings, we performed V-H gene analysis of 110 patients, revealing that 18 (16%) patients had mutated and 92 (84%) patients had unmutated V-H g
To date, it is widely accepted that several disorders of the male and female urogenital tract, such as erectile dysfunction, bladder overactivity, urinary stone disease and the benign prostatic syndrome, can be therapeutically approached by influencing the function of the smooth musculature of the respective organs. In order to achieve a pronounced drug effect without significant adverse events, e
This report is the thesis of the research and development project entitled: Development of a Resource Saving Concept for the Establishment of a Climate Suitable for the Storage of Objects Worthy of Preservation in Storerooms at Museums and in Archives. In short: The ZEPHYR project. This work is the result of a research and development project. The aim is to improve the possibilities of using pass
It is still impossible to make an accurate, purely theoretical prediction of the free energy of a ligand binding to a protein in aqueous environment. The two main problems are the immense number of nuclear configurations contributing to the binding free energy and the impossibility to apply accurate quantum-chemical methods to such a large system, even for a single configuration. In this thesis, t
Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1 alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes. We studied the effect of f
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two prevalent neurodegenerative disorders for which the causes are unknown, except in rare familial cases. Several changes in neuropeptide levels as measured by radioimmunoassay (RIA) have been observed in these illnesses. Somatostatin (SOM) levels in cerebrospinal fluid (CSF) are consistently decreased in AD and FTD. Neuropeptide Y (N
The prognosis of patients with advanced stages of neuroblastoma with N-myc amplification remains poor despite escalated therapy, a situation that has called for alternative therapeutic approaches. Neuroblastoma cells, which represent immature peripheral neuronal cells, treated with certain physiologic and nonphysiologic agents such as retinoic acid (RA), phorbol esters and interferons (IFN) in vit
BACKGROUND: Singletons born after IVF have an adverse perinatal outcome when compared with singletons in the general population. This study investigates maternal characteristics and IVF-treatment-related variables, for a possible influence on obstetric outcomes. METHODS: Data from all IVF clinics in Sweden, including all IVF singletons born after fresh treatment cycles and own oocytes during 2002-
BACKGROUND: The escalating global epidemic of obesity is of worldwide concern because of its association with several chronic diseases and premature mortality. Some subgroups seem to be more affected than others. The aim of this study was to examine whether the mean BMI (adjusted for age) and the prevalence of obesity (adjusted for all the explanatory variables) changed between 2000/01 and 2004/05
Popular Abstract in Swedish Den cancerskyddande genen p53 är av betydelse för att göra leukemiceller friska. Blodbildning. Blodceller är nödvändiga för vårt välbefinnande och vår överlevnad. Det finns flera olika typer med egna specialiserade funktioner. Så krävs t. ex. röda blodkroppar för syresättning och vita blodkroppar för att bekämpa infektioner. Blodcellerna har begränsad överlevnad; när Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle
Kunskap om markens uppbyggnad är viktig både för konstruktions och prospekteringsändamål. Geofysiska undersökningsmetoder kan användas för att skapa en överblick att basera vidare undersökningar på. I den här studien används likströms resistivitet och inducerad polarisation, IP. Datan är inverterad med en Cole-Cole modell i programmet ÅrhusInv och använd för att karakterisera berggrunden vid ÖnnesFor both construction and exploration purposes, knowledge of the subsurface is important. Geophysical exploration methods can be used to acquire an overview of an area on which further investigations can be based. In this study direct current resistivity and induced polarization data, inverted with a Cole-Cole model in program AarhusInv, are used to characterize the bedrock at Önneslöv in Scania,
In our everyday life we live distant from the origin of life itself - nature. Dramatic landscape and fascinating views touch us in a way that few other things manage to do. It is something that make us recognize our powerlessness and the feeling of awe towards the nature. Experiencing striking nature is a way to create a deeper understanding of our own world and at the same time enrich our lives w
Att ha förtalat någon är att ha begått ett brott. Men processrätten kring förtalsbrottet skiljer sig från vanliga brott. Om brottet varit tillräckligt kvalificerat tar åklagare över åtalet som ett allmänt åtal men om det inte nått upp till denna gräns har det ålegat den enskilde att väcka åtal. Det är främst den typen av brott som inte nått upp till gränsen för allmänt åtal som denna uppsats tagitTo have slandered someone is to have committed a crime. But the procedure surrounding the crime of slander differs from regular crimes. If the crime is considered qualifying enough a prosecutor will take over the case as general prosecution but if the crime hasn’t lived up to that level it’s up to the individual to arouse individual prosecution. It’s mainly the type of offense that doesn’t qualify
En fråga som har diskuterats i den folkrättsliga debatten en längre period gäller hur man ska se på statsföreträdare som gör sig skyldiga till internationella brott. I och med etablerandet av olika internationella domstolar och tribunaler har principen om individuellt straffrättsligt ansvar stärkts, då inget immunitetsskydd åtnjuts inför dessa domstolar. Härtill följer dock att de internationella A matter that has been discussed in the international legal debate for a long period of time is the one regarding state officials found guilty of international crimes. With the establishment of various international courts and tribunals, the principle of individual criminal liability has been strengthened, since no immunity is enjoyed before such courts. However, the jurisdictional scope of the in
A part of the project of transforming the worn down medieval fortress Glimmingehus into a tourist attraction for the people of the 20th century, was to dig out the once filled in moat surrounding it. This very labour intensive project did not only result in a nostalgic atmosphere but also a large amount of fairly well preserved finds, since the moat had once been used as a rubbish dump. A part of
I Cover Photo: Siti Khatijah Market, Kelantan, Malaysia - Alex Hudson/Unsplash A boy watering plants – Ninja SS/Shutterstock Fisherman walking with fresh tuna – Renata Apanaviciene/Shutterstock Pham Ngu Lao St, Ho Chi Minh City, Viet Nam - Olga Ozik/Pixabay 1 Prosperous and green in the Anthropocene: The human right to a healthy environment in Southeast Asia Claudia Ituarte-Lima Victor Bernard Del
https://rwi.lu.se/wp-content/uploads/2020/12/Prosperous-and-green-in-the-Anthropocene-Report_-index-THAI.pdf - 2026-05-31
I Sverige råder idag förbud mot anonyma vittnen men ämnet har diskuterats i omgångar sedan år 1990 i Sverige. De senaste åren har gängkriminaliteten ökat vilket har blåst liv i debatten igen. Politiker anser att ett införande av anonyma vittnen kan få fler personer att vittna i rättegångar rörande organiserad brottslighet. Så sent som den tredje april år 2019 beslutade riksdagen att tillsätta en uThe use of anonymous witnesses is today prohibited in Sweden but the subject has been fiercely debated since 1990. In the past recent years organized crime has increased which has reignited the debate once again. By passing a law that allows for anonymous witnesses, politicians believe more people will be willing to testify in criminal cases featuring organized crime. The Swedish parliament decide
En ny lagstiftning och avsaknad av praxis har medfört att rättstillämpningen avseende bedömning av påföljd och straffvärde för penningtvättsbrott är oklar. Mot bakgrund av att antalet anmälda fall av penningtvättsbrott ökat, är det av största betydelse att rättstillämpningen är förutsebar och rättssäker. Syftet med denna uppsats har därför varit klargöra rättsläget och utifrån en tillämpning av Due to new legislation and lack of case-law, it has been stated that the application of the law regarding sentencing and the assessment of the penal value for money laundering offences is unpredictable and uncertain. Given that the number of reported cases is constantly increasing, it is of utmost importance that the application of law is predictable and legally secure. Therefore, the purpose of
Abstract Authors: Ingrid Leandersson, Malin Jönsson Title: The situation of children at women’s shelters – A qualitative study of the work with children in women’s shelters based on the staff’s perspective Supervisor: Malinda Andersson Assessor: Mikael Sandgren The purpose of our essay was to highlight the situation among children in women's shelters in Sweden in addition to inquire into t
Enligt artikel 6 Europakonventionen har varje person som befinner sig under en medlemsstats jurisdiktion rätt till en rättvis rättegång. Till de rättigheter som härvidlag följer hör bland annat oskyldighetspresumtionen, innebärande att varje person som står anklagad för brott tillförsäkras att bli betraktad som oskyldig fram till att vederbörandes skuld lagligen fastställts. En förutsättning för oArticle 6 of the European Convention for the Protection of Human Rights and Fundamental Freedoms (European Convention) guarantees every person charged with a criminal offence under the jurisdiction of a Member State the right to a fair trial. Thereby, for a trial to be considered fair, certain general requirements need to be considered. Essential elements in this matter are the presumption of inno
