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PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq

Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise

Abstract: Title: Intelligent housing. Author: Tobias Nilsson, Student at Lund University. Director: Petter Wallentén, Senior Lecturer at the Department of Building Physics, Lund University. Examiner: Mats Dahlblom, Lecturer at the Department of installation and climate con-trol, Lund University. Problem identification: • What techniques and systems are making homes intelligent? • What opportunitie

Byggsektorn har stor miljöpåverkan och det är viktigt att byggentreprenader genomförs på ett sätt som följer de miljömål som finns. Genom offentlig upphandling har myndigheter en stor möjlighet att inverka på miljöpåverkan, genom att ställa krav på att deras byggentreprenader följer vissa miljökriterier. De undersökta miljöcertifieringarna skulle då kunna utgöra utmärkta medel för att på ett strukThe construction sector has great impact on the environment and it is important that the public work contracts are carried out in a way that the environmental objectives requires. Authorities have an opportunity to influence the environment by requiring that all public works contracts obtain certain environmental criteria by means of public procurement. The studied green building certificates coul

Artificiell intelligens får ett allt större utrymme i den allmänna debatten och dess användningsområde växer hela tiden. Ett användningsområde som blivit allt är Kreativ AI. Kreativ AI syftar till att återskapa den mänskliga kreativiteten genom att skapa konstnärliga och litterära alster. Denna uppsats syftar till att belysa och besvara några av de centrala upphovsrättsliga utmaningarna och frågesArtificial intelligence is gaining more and more room in the public debate, and its field of application is constantly growing. One area of use that has become bigger is computational creativity. Computational creativity aims to recreate human creativity by creating artistic and literary works. This essay aims to highlight and answer some of the vital copyright challenges and issues posed by Compu

Lund's Climate Alliance was initiated 2010 by the municipality of Lund, in southern Sweden, to support local climate adaptation and mitigation efforts. The purpose of this paper is to investigate what each member of Lund's Climate Alliance believes will be necessary to realize sustainability goals particular to their organization in the future. The study thereby points to new topics, activ

Svensk kriminalpolitik har de senaste decennierna präglats av en ökad tendens till repressionshöjningar, vilket åskådliggörs bland annat av att svensk strafflagstiftning har varit föremål för utvidgning sedan slutet av 1900-talet. Tendensen har benämnts den straffande vändningen, kännetecknad av alarmism och populism. Parallellt med expansionen av strafflagstiftningen förefaller lagstiftarens benäIn the last decades Swedish criminal policy has been characterized by increased repression, which is shown by the fact that Swedish penal legislation has been expanded since the end of the 20th century. The expansion has been denoted the punitive turn, distinguished by alarmism and populism. Alongside the expansion of penal legislation, the legislator’s disposition to expand the possibilities of v

This paper examines the impact of zombie firms on healthy companies’ growth indicators in the Swedish market. By utilising fixed-effects regression analysis and analysing a comprehensive data set, the paper aims to shed light on the dynamics between zombies’ effects on nonzombies’ development. The findings indicate that zombies have limited effects on healthy companies in Sweden. Contrary to previ

This study explored the diverse experiences of five transgender individuals during medical gender-affirmation, and captured their active and dynamic strategies for the avoidance of discrimination. The Coordination between Expression and Intelligibility Demands model was developed through informed grounded theory analysis of the data generated in semi-structured interviews. The model reflects the e

Almost half of the energy consumption in the EU originates from heating and cooling of buildings. The European Commission states that smart control of building systems may reduce the energy consumption. Cloud based smart control or even advanced fault-detection systems are becoming more common and should work for any building in the world. These systems need to receive data from the physical build

This thesis provides an analysis of three photographs from the New Mothers-series by Rineke Dijkstra, which serve as a point of entry for a discussion on how the maelstrom of visual expressions surrounding the contemporary subject is transforming his/her experience of what is real in relation to visual expressions. In the exploration, the concept of “the real” is examined in its construction and a

Background: Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia. Methods: We conducted a prospective study with 403,506 partici

Background: Little is known about whether the protective effect of marriage on alcohol use disorder (AUD) varies by cultural background. Aims: Using Swedish national data, we examined whether marriage is associated with a stronger reduction in AUD risk among Swedes of a Swedish background (i.e. those with two Swedish-born parents) compared to Swedes with a foreign background (i.e. one or two forei

BackgroundHypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation.Methods and ResultsThis was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation b

Background and aim: Patient activation (PA) and Patient Involvement (PI) are considered elements in good survivorship. We aimed to evaluate the effect of a follow-up supported by electronic patient-reported outcomes (ePRO) on PA and PI. Method: From February 2017 to January 2019, we conducted an explorative interventional study. We included 187 patients followed after intended curative complex sur

BACKGROUND: Medium vessel occlusions (MeVO) can be either isolated events (primary), or secondary to thrombus migration from a large vessel occlusion to a medium-sized vessel. Outcomes following endovascular thrombectomy (EVT) in the middle cerebral artery (MCA) may differ between primary and secondary MeVOs. This study aimed to assess the association between primary/secondary MeVOs and clinical o

Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods: This was a propensity score–matched, prospective cohort