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BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s

Solid grafts of autologous superior cervical ganglia (SCG) or fetal locus coeruleus (LC) were implanted unilaterally into a fimbria-fornix lesion cavity adjacent to the hippocampal formation after a 6-hydroxydopamine lesion of the intrinsic noradrenergic system. Twelve to 15 months after transplantation, one microdialysis probe was implanted in the dorsal hippocampus ipsilateral to the graft, and

Background: Domestic violence is a global health problem as well as a violation against human rights. The aim of this study was to explore prevalence and incidence of domestic violence during pregnancy and 1 to 1.5 years postpartum as well as to explore the history of violence among new mothers in the southwestern region of Sweden. In addition, the aim was to explore the association between domest

The European Open Science Cloud is a pan-European initiative that aims at developing a federated infrastructure that supports scientific research and Open Science. Having the FAIR principles at the core of Open Science practices, the Environmental Research Infrastructures (ENVRIs) that operate in Europe collaborate at cluster level (the ENVRI cluster) continuously improving the FAIRness of their s

Information relating to errors in evapotranspiration (ET) products, including satellite-derived ET products, is critical to their application but often challenging to obtain, with a limited number of flux towers available for the sufficient validation of measurements. Triple collocation (TC) methods can assess the inherent uncertainties of the above ET products using just three independent variabl

The World Energy Council ranks the Danish energy system among best in the world judging by the energy trilemma criteria: energy security, energy equity, and sustainability. District heating (DH) and CHPs are pivotal for this ranking. This brief historical account illustrates how a mix of historical events, collective societal experiences, cultural and political values inform the Danish history of

Importance: Meningioma is the most common subsequent neoplasm following cranial irradiation among survivors of childhood cancer, but there are still uncertainties regarding the magnitude of the radiation dose-response association, potential modifiers of radiation risks, and the role of chemotherapy. Objective: To evaluate meningioma risk in survivors of childhood cancer following radiotherapy and

This article is about psychiatric patients’ life stories. I explore how best to handle patient narratives in the history of medicine and, more specifically, in the history of psychiatry. By applying a narrative and phenomenological analysis – seldom used in historical studies of psychiatry and psychiatric care – the aim is a new understanding of patient stories both as historically situated and as

BACKGROUND AND AIMS: Genetic variants involved in vitamin D metabolism have been associated with diabetes and related syndromes/diseases. We wanted to investigate possible associations of polymorphisms in genes involved in vitamin D metabolism with indices of insulin resistance and insulin secretion, and also with development of diabetes after gestational diabetes mellitus (GDM).MATERIALS AND METH

The essay aims at decoding the 1954 novel The Sound of Waves in relation to Mishima’s biography, political and aesthetic theory, arguing that his most serene artistic achievement is, in the end, a desperate self-deluding for various inner contradictions. In a minute hermeneutic approach the article identifies and interprets such defining issues as: suicide, loneliness, individualism, egoism, mater

Objectives: To analyse the living conditions and social outcomes (housing, engagement in employment or higher education, access to personal assistance and having a partner) in adults with cerebral palsy (CP) relative to their age, sex, communication ability, and motor skills. Methods: Cross-sectional registry-based study of 1,888 adults (1,030 males/858 females) with CP in the Swedish CP follow-up

Background: Women's fears and attitudes to childbirth may influence the maternity care they receive and the outcomes of birth. This study aimed to develop profiles of women according to their attitudes regarding birth and their levels of childbirth related fear. The association of these profiles with mode and outcomes of birth was explored.Methods: Prospective longitudinal cohort design with self

Recent studies have indicated a decline in sperm number in the western world during the past 50 years, sperm concentration changing from 113 to 66 millions per mL. Furthermore, significant geographical differences in male reproductive function have been observed. In Finland, the sperm concentration was found to be substantially higher than in Denmark. In parallel, the incidence of testicular cance

Popular Abstract in Swedish Påverkan av faktor V Leiden-mutationen på risk för utveckling av neovaskulära komplikationer efter centralvenstrombos studerades. Hos patienter med mutationen var risken nästan tre gånger högre att utveckla neovaskulära komplikationer än hos patienter utan mutationen. Synnervssvullnad , som nyligen har presenterats som en indikator på god prognos vid centralvenstrombosThe influence of the factor V Leiden mutation on the development of neovascular complications in central retinal vein occlusion was studied. The presence of the mutation was found to enhance the risk of developing neovascular complications almost threefold compared to in patients without the mutation. Optic nerve head swelling, which recently has been presented as an indicator of good prognosis i

Huvudsyftet med denna pilotstudie var att undersöka anknytningsrepresentationer hos ensamstående kvinnor i Sverige som planerar eller överväger att skaffa barn, som väntar barn eller som har fått barn genom assisterad befruktning (donatorinsemination). Upplevelser av social acceptans relaterat till deras val att frivilligt bli ensamstående mödrar undersöktes också. Som metod användes Adult AttachmThe main aim of this pilot study was to explore inner representations of attachment in single women in Sweden that were planning to have children, that were expecting children or that have had children on their own through assisted reproduction (donor insemination). Experiences of social acceptance regarding their choice to parent alone were also examined. The methods used were The Adult Attachmen

Another link in the immune cell chain Cardiovascular disease (CVD) is the number one cause of death in the western world. The main cause of CVD is atherosclerosis, a chronic inflammatory disease of the major arteries. Atherosclerosis can be described as by a build up of plaque in medium to large arteries. Clinical complications, such as heart attack and stroke, occur when plaques rupture and form

Kristianstadsslätten breder ut sig i nordöstra Skåne och in i sydvästra Blekinge med sin komplicerade och varierade geologi. De komplexa förhållandena leder till att det finns ett flertal akvifärer i både jordlager och berggrund, där den mest vattenförande formationen är den av glaukonitsand. Syftet med arbetet har varit att undersöka vilket infiltrerat vattenflöde, vid vilket pumptryck, en brunn Kristianstad plain stretches from the northeast of Scania to the southwest of Blekinge with a complicated and varying geology. The complexity has resulted in multiple aquifers in both soil and bedrock, where the highest amount of withdrawable groundwater is in the formation of glauconite sand. The aim of this paper has been to investigate which infiltrated water flow at a certain pumping pressure,

Den 30 mars 2017 presenterade Finansdepartementet Vissa frågor inom fastighets- och stämpelskatteområdet (SOU 2017:27), även kallat paketeringsutredningen. Förslagen som utredningen presenterade innebär bland annat att transaktioner med paketerade fastigheter ska beskattas symmetriskt med lagfartsöverlåtelser, till skillnad från nuläget då de kan ske skattefritt genom försäljning av näringsbetingaOn March 30th 2017 the special appointed committee from the Swedish Treasury Department presented Vissa frågor inom fastighets- och stämpelskatteområdet (SOU 2017:27), also known as “paketeringsutredningen”. Suggestions from the public investigation include among other things amendments stating that transactions of incorporated real estate should be taxed symmetrically with traditionally transacti