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Research | Centre for Mathematical Sciences Hoppa till huvudinnehåll Den här webbplatsen använder cookies för att förbättra användarupplevelsen. Genom att fortsätta använda webbplatsen samtycker du till att cookies används enligt vår cookie-policy (på LTH:s webbplats) . Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan inte stängas av i våra system. Des

https://www.maths.lu.se/english/research/staff/mario-natiello/research/ - 2026-05-26

Abstract in Undetermined We present an efficient method for importance sampling the product of multiple functions. Our algorithm computes a quick approximation of the product on the fly, based on hierarchical representations of the local maxima and averages of the individual terms. Samples are generated by exploiting the hierarchical properties of many low-discrepancy sequences, and thresholded ag

This report is the thesis of the research and development project entitled: Development of a Resource Saving Concept for the Establishment of a Climate Suitable for the Storage of Objects Worthy of Preservation in Storerooms at Museums and in Archives. In short: The ZEPHYR project. This work is the result of a research and development project. The aim is to improve the possibilities of using pass

BACKGROUND: Singletons born after IVF have an adverse perinatal outcome when compared with singletons in the general population. This study investigates maternal characteristics and IVF-treatment-related variables, for a possible influence on obstetric outcomes. METHODS: Data from all IVF clinics in Sweden, including all IVF singletons born after fresh treatment cycles and own oocytes during 2002-

The first paper, Pharmaceutical R&D: a real option approach, considers the process of pharmaceutical R&D analyzed with real option theory. This process is analyzed as an opportunity to research and develop a new pharmaceutical. Contrary to other models using real option analysis I use an option that takes time to exercise. Thus, the important aspect of long R&D processes when developin

To date, it is widely accepted that several disorders of the male and female urogenital tract, such as erectile dysfunction, bladder overactivity, urinary stone disease and the benign prostatic syndrome, can be therapeutically approached by influencing the function of the smooth musculature of the respective organs. In order to achieve a pronounced drug effect without significant adverse events, e

My focus is on pragmatic arguments for various rationality constraints on a decision maker’s state of mind: on his beliefs or preferences. An argument of this kind purports to show that a violator of a given constraint can be exposed to a decision problem in which she will act to her guaranteed disadvantage. Dramatically put, she can be exploited by a clever bookie who doesn’t know more than the a

Bifacial PV cells have the capacity to produce solar electricity from both sides and, thus, amongst other advantages, allow a significantly increase both in peak and annual power output while utilizing the same amount of silicone. According to the manufacturer, the bifacial cells are around 1.3 times more expensive than the single-sided cells. This way, bifacial PV cells can effectively reduce the

It is still impossible to make an accurate, purely theoretical prediction of the free energy of a ligand binding to a protein in aqueous environment. The two main problems are the immense number of nuclear configurations contributing to the binding free energy and the impossibility to apply accurate quantum-chemical methods to such a large system, even for a single configuration. In this thesis, t

Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1 alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes. We studied the effect of f

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two prevalent neurodegenerative disorders for which the causes are unknown, except in rare familial cases. Several changes in neuropeptide levels as measured by radioimmunoassay (RIA) have been observed in these illnesses. Somatostatin (SOM) levels in cerebrospinal fluid (CSF) are consistently decreased in AD and FTD. Neuropeptide Y (N

The prognosis of patients with advanced stages of neuroblastoma with N-myc amplification remains poor despite escalated therapy, a situation that has called for alternative therapeutic approaches. Neuroblastoma cells, which represent immature peripheral neuronal cells, treated with certain physiologic and nonphysiologic agents such as retinoic acid (RA), phorbol esters and interferons (IFN) in vit

Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V-H genes. We also reported restricted use of certain V-H genes. To assess the prognostic impact of these new findings, we performed V-H gene analysis of 110 patients, revealing that 18 (16%) patients had mutated and 92 (84%) patients had unmutated V-H g

BACKGROUND: The escalating global epidemic of obesity is of worldwide concern because of its association with several chronic diseases and premature mortality. Some subgroups seem to be more affected than others. The aim of this study was to examine whether the mean BMI (adjusted for age) and the prevalence of obesity (adjusted for all the explanatory variables) changed between 2000/01 and 2004/05

Popular Abstract in Swedish Den cancerskyddande genen p53 är av betydelse för att göra leukemiceller friska. Blodbildning. Blodceller är nödvändiga för vårt välbefinnande och vår överlevnad. Det finns flera olika typer med egna specialiserade funktioner. Så krävs t. ex. röda blodkroppar för syresättning och vita blodkroppar för att bekämpa infektioner. Blodcellerna har begränsad överlevnad; när Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle

V&S Sundsvall (a part of V&S Vin & Sprit AB) is a Swedish company producing different alcoholic beverages, mainly for the Swedish market. The company has lately paid increasing attention to supply chain disruption risk issues. In another study, one of the authors (Paulsson 2007) developed a model, called the DRISC (Disruption Risks In Supply Chains) model, for the structuring, evaluati

Kunskap om markens uppbyggnad är viktig både för konstruktions och prospekteringsändamål. Geofysiska undersökningsmetoder kan användas för att skapa en överblick att basera vidare undersökningar på. I den här studien används likströms resistivitet och inducerad polarisation, IP. Datan är inverterad med en Cole-Cole modell i programmet ÅrhusInv och använd för att karakterisera berggrunden vid ÖnnesFor both construction and exploration purposes, knowledge of the subsurface is important. Geophysical exploration methods can be used to acquire an overview of an area on which further investigations can be based. In this study direct current resistivity and induced polarization data, inverted with a Cole-Cole model in program AarhusInv, are used to characterize the bedrock at Önneslöv in Scania,

In our everyday life we live distant from the origin of life itself - nature. Dramatic landscape and fascinating views touch us in a way that few other things manage to do. It is something that make us recognize our powerlessness and the feeling of awe towards the nature. Experiencing striking nature is a way to create a deeper understanding of our own world and at the same time enrich our lives w

Principen om den fria åsiktsbildningen är grundläggande för vår demokrati. Syftet med denna uppsats är att undersöka om det föreligger en konflikt mellan den grundlagsstadgade svenska demonstrationsfriheten och de folkrättsliga förpliktelser Sverige åtagit sig genom att reservationslöst ratificera FN-konventionen om avskaffande av alla former av rasdiskriminering. Sverige har sedan anslutandet tilThe principle of freedom of opinion is fundamental in our democracy. The ambition of this thesis is to examine whether there is a conflict between the constitutional right to demonstrate and the international obligation Sweden has undertaken when, without reservations, ratifying the International Convention on the Elimination of all Forms of Racial Discrimination. Ever since 1971, when Sweden ente