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Background: Smoking is probably the most important among preventable health risks. Health economic evaluation of smoking-cessation interventions, applying a lifetime perspective, is made possible by available epidemiological knowledge. The well established method of performing cost-effectiveness analyses of smoking-cessation interventions involves mathematical modelling (both deterministic and sto
Background - Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results - Five pa
In 1996, Robert A. Haugen and Nardin L. Baker published a study where they had made a multi-factor model based on micro-variables on the American stock market between 1979 and 1993. In testing the model on the examined period they made an average annual return of 30,9 percent. They also tested the model on several other markets around the world with similar results. This study is a somewhat simple
An electron transfer mediator, 8-dimethylamino-2,3-benzophenoxazine (Meldola Blue), dissolved in the carrier solution in a flow-injection system, was found to reduce the oxidation potential for hydrogen peroxide from 600-1200 mV without mediator to - 100 mV vs. Ag/AgCl with the mediator present. The very low background current of reticulated vitreous carbon (RVC) at this potential makes it possibl
The thesis work concerns development and application of four versatile nonlinear optical techniques, based on exploiting ultrashort laser pulses, for diagnostic purposes in gases and flames. The four techniques, all laser-based, are two-photon laser-induced fluorescence (TPLIF), hybrid femtosecond/nanosecond (fs/ns) rotational coherent anti-Stokes Raman scattering (fs/ns RCARS), fs-laser-induced g
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
UNLABELLED: To clarify the role of the TNFRSF11B gene encoding osteoprotegerin (OPG), in Paget's disease of bone (PDB) we studied TNFRSF11B polymorphisms in an association study of 690 UK subjects and in a worldwide familial study of 66 kindreds. We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.INTRODUCTION: P
AbstractObjectives: Patients with inflammatory rheumatic diseases (IRDs) have higher risk of serious infections than healthy individuals due to their illness, comorbidities and treatments. Streptococcus pneumoniae is responsible for 30-50% of community aquired pneumonia in Europe.The proportion of patients with IRD receiving vaccination against pneumococci is still estimated to be suboptimal. The
Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple mulholger, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived to be at risk of excess toxicity. To determine whether melphalan 200 mg/m2 and melphalan 140 mg/m2 are equally effective and tolerable in clinically relevant patient subgroups w
The aim of this study was to investigate calcium chloride-induced gelatinization of oat starch, and its effects on the properties of oat starch-based Pickering emulsions. The starch granules were gelatinized in CaCl2 for up to 24 h and the results indicate that the salt-induced gelatinization of oat granules is not a surface phenomenon, as gelatinization and dissolution of the whole starch granule
Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP
BACKGROUND: Gout is the most common inflammatory arthritis with a rising prevalence around the globe. While educational inequalities in incidence and prevalence of gout have been reported, no previous study investigated educational inequality in mortality among people with gout. The aim of this study was to assess absolute and relative educational inequalities in all-cause and cause-specific morta
Importance: Mitochondrial disease is being diagnosed with increasing frequency. Although children with mitochondrial disease often have severe, life-limiting illnesses, many survive into adulthood. There is, however, limited information about the impact of mitochondrial disease on healthcare utilization in the U.S. across the lifespan. Objectives: To describe the characteristics of inpatient hospi
In recent decades, information technology has enjoyed an ever-increasing degree of influence upon society. The use of technology has proliferated, bleeding into all human activities, and now extends into the most private activities of individuals. Unfortunately the perpetrators of serious crimes have not missed the revolution. Technology has marked off many working terrains including that of serio
The general rule in EC law is that a holder of an intellectual property right is not obliged to license the use of that right to others. However, situations exist where intellectual property rights suffer some limitations because of the prevalence of other conflicting interests. A dominant firm can, as the holder of an intellectual property right, be forced to grant a license to one or more undert
Elektromagnetiska vågor, även kända som radiovågor, är vågor som sprider sig med låga frekvenser från 3 till 30 kHz. Dessa lågfrekventa vågor används vanligtvis när man önskar kommunicera med ubåtar. De kan emellertid också användas på land för att mäta skillnader i jord– och bergarters elektriska konduktivitet. Denna mätteknik kallas Very-Low-Frequency Electromagnetics (VLF-EM) och har framgångsrElectromagnetic waves, also known as radio waves, which propagate at low frequencies of only 3 kHz to 30 kHz, are usually used for communication with submarines. However, these waves can also be used on land to measure differences in the electrical conductivity of the subsurface. This technique is called Very-Low-Frequency Electromagnetics (VLF-EM) and has been successfully used to gain an insight
Risk and vulnerability assessments are an important part of the Swedish disaster management system and can be used as input for decision making. Today disaster management decisions are made on all levels in Sweden depending on the extent of the decisions. The purpose of this thesis has been to perform a descriptive study of how risk and vulnerability assessments are utilised as input to decision m
The profound impacts on human rights brought about by international and regional trade agreements have increasingly been recognized by scholars in the fields of human rights and trade, as well as international organizations and civil societies. Most notably, the intersection between human rights and trade has been reaffirmed by the United Nations, evidently in the reports by the United Nations Hig
