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The possible teratogenic effect of erythromycin therapy, noted previously, was studied. Women who had taken erythromycin or penicillin V in early pregnancy and their infants were studied, using the Swedish Medical Birth Register where information on drug use during pregnancy was recorded based on interviews in early pregnancy. The risk for any congenital malformation after erythromycin therapy (bu
The possibility to simulate lepton number violating supersymmetric models has been introduced into the recently updated Pythia event generator, now containing 1278 decay channels of SUSY particles into SM particles via lepton number violating interactions. This generator has been used in combination with the AtlFast detector simulation to study the impact of lepton number violation (4) on event to
The development of inhibitory antibodies to factor (F) VIII and FIX continues to be a major challenge in the treatment of patients with hemophilia. In patients with low-responding inhibitors, it is usually possible to saturate the inhibitor with the deficient factor and to achieve hemostasis, but in patients with high-responding inhibitors, two major tasks have to be considered. One is how to trea
Background Subjective evaluation of gray-scale and Doppler ultrasound findings (i. e., pattern recognition) by an experienced examiner and preoperative serum levels of CA-125 can both discriminate benign from malignant adnexal ( i. e., ovarian, paraovarian, or tubal) masses. We compared the diagnostic performance of these methods in a large multicenter study. Methods In a prospective multicenter s
This study aimed to investigate if there is an association between bacterial vaginosis (BV) and smoking. This cohort study included 956 randomly chosen, apparently healthy women at 2 family planning and one youth clinic. Of the 956 women, 131 women fulfilled the criteria for BV and the remaining 825 served as a control group. BV, BV-associated bacteria and gynaecological infections were diagnosed.
Background. Evidence-based medicine (EBM) has become widely accepted as a basis for clinical decision in many fields of medicine. This review examines the specific role of EBM in hepato-biliary and pancreatic (HBP) surgery. EBM relies on four main sources, including clinical guidelines, meta-analyses, primary information and clinical experience. Randomized controlled trials (RCTs) constitute the c
The grafting of functional polymers to the pore surface of macroporous monolithic polyacrylamide cryogels was found to be an efficient and convenient method for the preparation of macroporous polyacrylamide gels, so-called cryogels (pAAm cryogels), with both controlled extent of functional group incorporated and with tailored surface chemistries. Anion-exchange polymer chains of poly(2-(dimethylam
Rhabdom adaptation and its phylogenetic significance. Zool. Scr. 5 (3–4): 97–101, 1976. — The rhabdoms of arthropod compound eyes are structurally differentiated into open, fused layered, and fused continuous. All are capable of perceiving polarized light. The fused layered, and under certain conditions the fused continuous, perform particularly well. — The fused layered rhabdoms occur in malacost
Popular Abstract in Swedish Hydrosilyleringsreaktionen är formellt en addition av en hydrosilan till ett omättat system. Reaktionen är oftast katalyserad av en övergångsmetall, och i denna process är det möjligt att påverka på vilket sätt additionen sker. Denna avhandling är en sammanfattning av fyra artiklar som behandlar regio-, stereo- och kemoselektivitet vid addition av hydrosilaner till konjThis thesis is a summary of four papers concerning various aspects on the transition metal catalysed hydrosilylation of 1,3-dienes. The hydrosilylation reaction is formally an addition of a hydrosilane to an unsaturated system and depending on the reaction conditions, control of stereo-, regio-, and chemo-selectivity can be achieved. Optically active heterobidentate P,N ligands were synthesised f
The possibilities of using structural reliability analysis in concrete dam design and assessment is investigated in Sweden. For such analysis statistical descriptions of the loads and resistances are necessary. Uplift pressure has a large impact on the safety and is difficult to quantify. In ‘Geostatistical approach for statistical description of uplift pressures: Part 1’*, the methodology of a ge
The aim of this was to determine whether the change of size observed at the first response evaluation after initiation of first-line combination chemotherapy correlates with overall survival (OS) in patients with metastatic breast cancer (MBC). The change in size of tumors derived from measurements according to Response Evaluation Criteria In Solid Tumors (RECIST) at the first evaluation on comput
BACKGROUND: Job strain, defined as high job demands and low job control, has not previously been explored as a possible determinant of male fertility. We collected prospective data on job strain among men, and describe the associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle. METHODS: Danish couples (N = 399) who were trying to become pregnant
The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat
Potassium diperiodatocuprate-initiated graft polymerization was found to be an efficient and convenient method for grafting of acrylic acid (AAc) onto superporous polyacrylamide gels, so called cryogels (pAAm cryogels). It was possible to achieve grafting degrees as high as 70% with about 25% yield of grafted polymer with respect to the initial amount of monomer. The superporous structure of the c
Pancreatic islet hormones regulate blood glucose homeostasis. Changes in blood glucose induce oscillations of cytosolic calcium in pancreatic islet cells that trigger secretion of three main hormones: insulin (from β-cells), glucagon (α-cells) and somatostatin (δ-cells). β-Cells, which make up the majority of islet cells and are electrically coupled to each other, respond to the glucose stimulus a
We study asymptotic properties of the following Markov system of N≥3 points in [0, 1]. At each time step, the point farthest from the current centre of mass, multiplied by a constant p>0, is removed and replaced by an independent ζ-distributed point; the problem, inspired by variants of the Bak–Sneppen model of evolution and called a p-contest, was posed in Grinfeld et al. (J Stat Phys 146, 378–40
Purpose: Gene therapy for RPE65 retinopathy has been recently approved. The purpose of this study was to assess retinal structure and function in 3 siblings presenting with late-stage RPE65 retinopathy and to assess the unmet need for such therapy in Saudi Arabia. Methods: Search of the retinal dystrophy registry at King Khaled Eye Specialist Hospital and clinical examination including multimodal
Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising from consumption of selenium dietary supplements. Thus, early studies report a decrease in the incidence of certain types of cance
One of the most significant roles of the EU in the world is that of being a norms exporter. The EU has concluded numerous agreements with countries in its neighbourhood with the aim of encouraging third countries to adopt EU acquis in exchange for access to the internal market. The most ambitious of these agreements are the three multilateral agreements establishing the European Economic Area, the
