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Popular Abstract in English Life on earth has evolved countless forms, beautiful shapes and colors as well as astonishingly complex systems. Remarkably, all living creatures consist of cells, which themselves are build from the same basic set of molecules, most importantly nucleic acids (RNA and DNA), lipids and proteins. The latter are large macromolecules that fulfill a vast number of tasks; theThe three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. We used the Fold-and-Dock algorithm, which is part of the Rosetta macromolecular modeling suite, for de novo structure prediction of coiled-coil proteins. Members of this protein family

NanoLund: Centre for Nanoscience

NanoLund är Lunds universitets centrum för forskning, utbildning och innovation inom nanovetenskap. Över 400 personer inom fakulteterna för teknik, naturvetenskap och medicin är verksamma i detta strategiska forskningsområde. Det finansieras av den svenska regeringen och är Sveriges största forskningsmiljö för nanovetenskap och nanoteknologi.

Under devisen ”A Great Place to do Nanoscience” vilNanoLund, the centre for research, education and innovation in nanoscience at Lund University, engages over 400 researchers, students and staff at the faculties of engineering, science and medicine. It is a strategic research area funded by the Swedish Government and Sweden’s largest research environment for nanoscience and nanotechnology.

Our ambition is to be a Great Place to do Nanoscience:

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With the growing pool of deposited protein structures, the need for structural analysis tools grows. In study of amino acid substitutions the variety of analysis tools is high; nevertheless, there is a lack of programs serving specific purpose, such as identifying if an amino acid substitution would cause a clash in the structure or not, given just the structure of the original protein. In this st

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In the study presented in this paper, a vehicle driving cycle simulation of the pneumatic hybrid has been conducted. The pneumatic hybrid powertrain has been modeled in GT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been converted to wor

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The emergence of blockchain technology enables entrepreneurs to raise capital in an innovative way, by addressing a crowd of online investors without the need for an intermediary. This phenomenon is known as token sales, and it may have the potential to revolutionize entrepreneurial finance. However, information asymmetry is particularly severe in this context, and the need for entrepreneurs to se

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Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i

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Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg