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We have evaluated the efficiency of two popular end-point methods to calculate ligand-binding free energies, LIE (linear interaction energy) and MM/GBSA (molecular mechanics with generalized Born surface-area solvation), i.e. the computational effort needed to obtain estimates of a similar precision. As a test case, we use the binding of seven biotin analogues to avidin. The energy terms used by M
Aims Triple-negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer (BC) deaths, owing to its intrinsic aggressiveness and a lack of treatment options, especially targeted therapies. Thus, there is an urgent need for the development of better targeted treatments for TNBC. Molecular alteration of AKT-3 was previously reported in oestrogen receptor (ER)-positive B
Aims: The neurotransmitter Neuropeptide Y (NPY) was previously reported as a minor autoantigen in newly diagnosed type 1 diabetes (T1D) patients. The single nucleotide polymorphism at rs16139 (T1128C, L7P) in the NPY gene was associated with an increased risk for the development of type 2 diabetes (T2D). We aimed to develop a radiobinding assay for NPY-L (Leucine) and NPY-P (Proline) autoantibodie
Application for Theme at Pufendorf IAS 2024 2 3 Pufendorf IAS Theme Application TEMPLATE FOR THEME APPLICATION START: SEPTEMBER 2027 Title of the Theme in English Title of the Theme in Swedish Participants Name Department, Faculty E-mail address, telephone Theme coordinator: Theme co-coordinator: Nominated Fellows Affiliation Dates for visit Postal address Pufendorfinstitutet, Lunds universitet,
https://www.pi.lu.se/en/sites/pi.lu.se.en/files/2026-06/2027%20Theme%20application%20template.docx - 2026-06-22
We evaluated the association between cardiopulmonary bypass (CPB) time during surgery for acute type A aortic dissection (ATAAD) and mid-term survival. Data of 1122 patients who underwent surgery for ATAAD in eight Nordic centers from January 2005 to December 2014 were retrospectively analyzed. An adjusted logistic regression analysis was performed to investigate the association of incremental 30
Background: Dissecting free tissue flaps can be challenging and time-consuming. Imaging technologies are typically used to assist with preoperative planning. However, conventional methods have limitations that could potentially be overcome by extended reality technologies. This systematic review aimed to evaluate the current use of extended reality (XR) in preoperative planning for microsurgical f
Aim: To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction. Methods: Children with unilateral ureteropelvic junction obstruction (2012–2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burde
BACKGROUND: Performance status (PS) is known as one of the strongest prognostic factors for survival in metastatic colorectal cancer patients. The aim of the present study was to analyze factors associated with poor PS assessed after resection for colorectal liver metastases and the impact on survival.METHODS: All patients undergoing curative resection for colorectal liver metastases between 2010
In rodent models of Parkinson disease in which transplants of dissociated rodent and human embryonic mesencephalic tissue, rich in dopamine neurons, have been studied, only 5-20% of the dopamine neurons survive the implantation procedure. We have investigated the effects of inhibiting free radical generation with two lazaroids, U-74389G and U-83836E, on the survival of embryonic rat dopamine neuro
In a controlled prospective randomized study the regimen doxorubicin (A) 40 mg/m2 + melphalan (M) 0.4 mg/kg was compared with A + M + cisplatin (C) 50 mg/m2 given every four weeks in advanced ovarian cancer, FIGO stage III or IV and with serous or anaplastic histology. From 1981 to 1983, 300 patients entered the study and 295 patients were evaluable for response, toxicity and long-term survival. A
Inbjudan I n s t i t u t i o n e n f ö r m i l j ö v e t e n s k a p l i g u t b i l d n i n g 2015-08-14 PRELIMINÄRT SCHEMA PRELIMINÄRT Schema för MVET10 miljöskydd, 15 hp ht 15 Kurstid: 31 augusti – 1 november 2015 Kursansvarig: Högni Hansson 0721-55 56 48, hogni.hansson@cec.lu.se Introduktion: måndagen den 31 augusti 2015, Ekologihuset, Maskrosen, kl. 10.15-11.00. Lärare: Högni Hansson hogni.ha
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mvet10_ht15_v2-2.pdf - 2026-06-22
Welcome to Compile A site for LU eScience LU eScience Compile is a common web page for research, education, and infrastructure related to the advanced usage of computers, storage, and networks, i.e., e-Science and e-Infrastructure, at Lund University, collectively referred to as LU eScience. Events Link to RSS 10 July 2026 14:00 to 15:00 | Seminar WASP Lighthouse at Lund Seminar - Edward A. Lee, D
https://www.compile.lu.se/start - 2026-06-21
The mentoring programme is optional for PhD students within the ClimBEco graduate research school. If you choose to join the mentoring programme, you will get tools to support your career planning, building and strengthening of networks and personal development - improving your self-knowledge and communication skills. The program is divided into joint mentee seminars and individual mentor meetings
https://www.cec.lu.se/form/climbeco-graduate-research-school-mentoring-programme-2020-2021 - 2026-06-21
Summer 2026Our office and telephone hours are cancelled during the period 8 June to 23 August. Answers to many common questions and concerns can be found on the Study Economics pages.We have a general e-mail address that is monitored, by different people, throughout the summer: admin [at] nek [dot] lu [dot] seStudy Administrator(Basic and intermediate studies)Azra Padjan Holiday: 1/7 - 12/8.Study
Beskattning av pokervinster har inte minst under 2011 varit ett ämne för många diskussioner i media. Vissa anser att det krävs stora inslag av skicklighet för att vara duktig på poker och att det inte borde anses vara ett lotteri. Denna skicklighetsaspekt var fall för prövning i HD under 2011 i den s.k. Grebbestadsdomen. Vissa ansåg att domen skulle direkt avgöra om pokervinster skulle komma att bTaxation on poker winnings have not the least in 2011 been a topic of discussion in the media. Some believe that it requires significant element of skill to be good at poker and that it should not be considered a lottery. This skill aspect was tried in the Supreme Court in 2011 in the so-called Grebbestad verdict. Some felt that the appeal would directly determine whether poker profits would be ta
