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Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. The underlying mechanisms involved in ATC tumorigenesis is under

Characterizing the sharing economy state of the research : A systematic map

The sharing economy is an emerging niche for innovation capable of disrupting established socio-technical and economic regimes. Because of this potential to cause radical changes in a wide array of domains, research in multiple disciplines addressing various aspects entailing this phenomenon is proliferating. In this emerging body of literature, the understanding and framing of the sharing economy

Prognostic regression models of life expectancy after diagnosis of Alzheimer’s disease – a 20-year follow-up.

Background: To determine characteristics that might affect survival times in Alzheimer’s disease (AD) patients treated with cholinesterase inhibitors (ChEI) in clinical practice, and create statistical models of estimated life-span after AD diagnosis. Method: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicenter study to evaluate the use of long-term ChEI therap

Autoimmunity plays a role in the onset of diabetes after 40 years of age

Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of a

MRI-targeted or standard biopsy for prostate-cancer diagnosis

BACKGROUND: Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. METHODS: In a multicenter, randomized, noninferiority trial, we assigned men

Burnout among school teachers : quantitative and qualitative results from a follow-up study in southern Sweden

BACKGROUND: Teachers are at high risk of stress-related disorders. This longitudinal study aimed to (a) identify which occupational, sociodemographic and life-style factors and self-efficacy at baseline that were of importance for burnout, (b) explore associations between changes in the studied factors versus changes in burnout, and (c) by interviews increase the understanding of perceived job dem

Genetically Determined Risk of Depression and Functional Outcome After Ischemic Stroke

Background and Purpose- Psychosocial factors can have implications for ischemic stroke risk and recovery. This study investigated the effect of genetically determined risk of depression on these outcomes using the Mendelian randomization (MR) framework. Methods- Genetic instruments for risk of depression were identified in a discovery genome-wide association study of 246 363 cases and 561 190 cont

Kfs p-koll 20181121

Microsoft Word - KFS p-koll 20181121 AL korr.docx Box 8084, 200 41 Malmö / Bergsgatan 31b Malmö /Tfn 040-325472 / Karin.goransson@kanslik.lu.se /www.performingarts.lu.se 1 Konstnär l iga fakultetsstyrelsen PROTOKOLL Sammanträdesdatum 2018-11-21 Dnr STYR 2018/352 NÄRVARANDE Ledamöter Anna Lyrevik dekan, ordförande Staffan Storm prodekan, vice ordförande Ann-Charlotte Carlén Musikhögskolan Eva Saeth

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/kfs_p-koll_20181121_.pdf - 2026-05-30

Heka22 2 schema miljohistoria vt 2018

1 VÅRTERMINEN 2018 MILJÖHISTORIA (HEK A22:2) SCHEMA LÄRARE: Alf Hornborg (AH) [kursansvarig] – Alf.Hornborg@hek.lu.se Andreas Malm (AM) – Andreas.Malm@hek.lu.se Thomas Malm (TM) – Thomas.Malm@hek.lu.se Linda Stihl (LS) – Linda.Stihl@keg.lu.se Föreläsningar sker om inget annat anges kl. 13-15 i ”Johannesburg” (J), Geocentrum 1, Sölvegatan 10. GIS-övningar sker i Smil. Datum Dag Tid Litteratur Lärar

https://www.keg.lu.se/sites/keg.lu.se/files/heka22_2_schema_miljohistoria_vt_2018.pdf - 2026-05-30

Associations of intraoperative end-tidal CO2 levels with postoperative outcome-secondary analysis of a worldwide observational study

BACKGROUND: Patients receiving intraoperative ventilation during general anesthesia often have low end-tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs) in a conveniently-sized international, prospective study named 'Local ASsessment of Ventilatory management during General Anesthesia for Surgery' (LAS

Dementia with Lewy Body (DLB) Symptoms Hidden within the Diagnosis “Dementia Not Otherwise Specified” a Cross-Sectional Study in 40 Swedish Nursing Homes.

Background: Dementia with Lewy Body (DLB) is a neurocognitive disorder with core features, such as Parkinsonism, visual hallucinations, and fluctuating cognition/ excessive daytime sleepiness, and supportive features, such as rapid eye movement sleep behaviour disorder. DLB is often misdiagnosed and unrecognized in elderly individuals. A diagnosis of DLB is important because of the risk of hyperse

Asthma and extrapulmonary comorbidities in a middle-aged general population : results from the SCAPIS study

Introduction Asthma may increase the risk of comorbidities and systemic inflammation, but population data are scarce. This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers. Methods In a cross-sectional analysis of 28 828 people aged 50–64 in the Swedish CArdioPulmonary

Patterns of sex-specific and age-specific risk indicators of suicide : a population-nested case-control study

Background Suicide is more common among males and in older age, but the understanding of sex-specific and age-specific risk indicators is limited. Objective To describe the sex-specific and age-specific prevalence of 25 suicide risk indicators in the year preceding suicide and estimate their associations with suicide. Methods Register-based population-nested case-control study in Sweden, 2009–2021

Human papillomavirus-related squamous cell carcinomas after blood or marrow transplantation - a Blood or Marrow Transplant Survivor Study report

Background Human papillomavirus (HPV) is associated with an increased risk for a variety of squamous cell carcinomas in the general population. The risk for subsequent squamous cell carcinomas in blood or marrow transplantation survivors that are potentially related to HPV (cervical, oropharyngeal, vulvar, vaginal, anal, and penile cancer; HPV-related squamous cell carcinomas) remains unknown. Met

Common Designs of Custom-Made Fenestrated Arch Devices and Applicability of an Off-the-Shelf Design

Objectives: To analyze device designs, similarities and overlaps of custom-made fenestrated arch endografts intended for mid/distal arch thoracic endovascular aortic repair. Materials and Methods: A multicenter cross-sectional study analyzing custom-made anonymized graft plans was performed. Graft plans were included from a cohort of mid/distal aortic arch repairs using custom-made fenestrated aor

Economic Impact of Severe Early-Onset Foetal Growth Restriction : A Multicentre Prospective Cohort Study

Objective: Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early-onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR. We determined the economic cost associated with severe early-onset FGR. Design: Econom

Parental Perceptions of Children's Weight Status in 22 Countries : The WHO European Childhood Obesity Surveillance Initiative: COSI 2015/2017

INTRODUCTION: Parents can act as important agents of change and support for healthy childhood growth and development. Studies have found that parents may not be able to accurately perceive their child's weight status. The purpose of this study was to measure parental perceptions of their child's weight status and to identify predictors of potential parental misperceptions.METHODS: We used data fro

A European survey on anaerobes from paediatric blood cultures: a comparative analysis with adults

Infections caused by anaerobes are common in children. However, limited data are available on bloodstream infections caused by these bacteria in Europe. A multicentre retrospective observational study was conducted over a 4-year period (2020–2023) across 44 European hospitals to analyze all anaerobes isolated from blood cultures. The study examined the epidemiology and antimicrobial resistance pro