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During the Middle Ages the concepts of `them and us' became concrete in the shape of fiercely defended frontiers, some of which were physical, geographic and political, while others were more ideological. This volume, the proceedings of an international symposium held at Lund University in 2000, presents twenty-four papers which examine the archaeological evidence for frontiers across Europe. Divi

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The circular economy is becoming a globalised phenomenon, but the regional emergence of circular business models differs significantly. By adopting a circular business institutionalisation perspective which bridges theory on institutional work and “ecologies of business models” we study the emergence of circular business models in Japan, a region with recent circular policy and business commitment

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This research monograph explores new frontiers in Markov chains. Although time-homogeneous Markov chains are well understood, this is not at all the case with time-inhomogeneous ones. The book, after a review on the classical theory of homogeneous chains, including the electrical network approach, introduces several new models which involve inhomogeneous chains as well as related new types of rand

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In 1735, professor Kilian Stobaeus donated his collections to Lund University laying the foundation for the university’s first museum. The ”Museum Stobaeanum” contained over 3000 natural history, historical and ethnographic objects typical of the cabinets of curiosity. This richly illustrated book is the first comprehensive history of these collections.Eighteen chapters, written by an interdiscip

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This chapter will analyse the Trade secret Directive from a technological informed legal perspective, looking at the possibilities and scope of protection that it offers for knowledge based activities and business models. It opens by restating the basic yet important fact that “Information is power”. Asymmetries in information are a fundamental transaction cost and in this sense informational qual

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The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth

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Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

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Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively

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Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

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Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces

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Råttan är en däggdjursart med en kort dräktighetstiden och föds därför mycket omogen. Den är vid födelsen naken, blind och döv och är helt beroende av sin moder för många funktioner, såsom näringstillförsel, termoreglering, urinering och tarmtömning. Under diperioden är råttans mag-tarmsystem och matsmältning helt anpassad till modersmjölkdieten. Bland annat är tarmens barriärfunktion omogen, vilk

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Background: Little is known regarding treatment with cangrelor during percutaneous coronary intervention (PCI) in patients with myocardial infarction complicated by cardiogenic shock or cardiac arrest. Objectives: The aim of this study was to investigate the effects of such cangrelor treatment during PCI in patients with myocardial infarction complicated by cardiogenic shock or cardiac arrest. Met