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Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Inhibition of IL-4Rα reduces CCL26 in bronchial epithelial cells from COPD patients

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Schema mven18 vt 20 version2rev

Prel.Schema MVEN018 - Klimatstrategiska metoder Vårterminen 2019 OBS Alla starttider med kvart utom tentamen! Kurstid: 23-mar – 7 juni Kurschef: Niklas Vareman Lärare: CW Christine Wamsler HT Henrik Tehler HH Henrik Hassel US Ullrika Sahlin DP Dmytro Perepolkin NV Niklas Vareman AO Adelina Osmani LS Linn Svegrup JJ Jonas Johansson JMP Jurate Miliute-Plepiene AP Andrius Plepys Salar: Mossen, Ekolog

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven18_vt_20_version2rev.docx - 2026-06-02

A combined experimental and theoretical study of uranium polyhydrides with new evidence for the large complex UH4(H-2)(6)

Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n

β-Mannan degradation by gut bacteria - Characterization of β-mannanases from families GH5 and GH26

Popular Abstract in Swedish Människan lever inte bara själv, utan tillsammans med en mängd bakterier som lever i kroppen. Större delen av dessa lever i tjocktarmen. Dessa organismer är viktiga för vår hälsa. De stimulerar immunförsvaret, sänker pH i tarmen och gör det ogynnsamt för sjukdomsframkallande bakterier att växa till. Bakterierna lever i symbios med oss och med varandra. Förändringar i taThe human gut flora is important for our well-being. The gut bacteria are able to degrade and metabolize complex carbohydrates. Examples of such carbohydrates are β-mannans. β-Mannans consist of a backbone of β-1,4-linked mannose units and are present in e.g. the endosperm of legumes such as guar or carob. The composition of the β-mannan varies with the plant source. Carob and guar β-mannans are s

Mos halvtidskontroll - variabellista 2019-02-20

MOS Variabellista inkl frekvenser - Halvtidskontroll (2018-06-13) Sida 1 av 50 Nr Name Format Variable label File Checked #B #BB Deltagare 1 lopnrMOS Numeric Löpnummer vid MOS baslinjeundersökning (Numerisk) MOS_Deltagare_halvtid.savAD 1326 1321 2 lopnrMOS_str8 String Löpnummer vid MOS baslinjeundersökning (Sträng, utan mellanstreck)MOS_Deltagare_halvtid.savAD 1326 1321 3 lopnrMOS_str9 String Löpn

https://www.malmo-kohorter.lu.se/sites/malmo-kohorter.lu.se/files/2024-03/mos_halvtidskontroll_-_variabellista_2019-02-20.pdf - 2026-06-02

Preliminart schema mven 18 vt19

Preliminärt schema MVEN 18 – Klimatstrategiska metoder Vårterminen 2019 OBS! Alla starttider med kvart utom tentamen! Kurstid: 25 mars – 9 juni 2019 Kursansvarig: Niklas Vareman Lärare: CW Christine Wamsler HT Henrik Tehler HH Henrik Hassel NV Niklas Vareman AO Adelina Osmani LS Linn Svegrup JJ Jonas Johansson JMP Jurate Miliute-Plepiene AP Andrius Plepys US Ullrika Sahlin Salar: Liganden (D202),

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/preliminart_schema_mven_18_vt19.pdf - 2026-06-02

Energy Storage & Conversion

Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r

https://www.energy.lth.se/research/energy-storage-conversion - 2026-06-01

Influence of the mannan binding module of beta-mannanase CfMan26A in the hydrolysis of mannan

Hemicellulose is next to cellulose the most abundant polysaccharide on earth and as such an important renewable resource. Mannans are the major hemicellulose in so:ftwodd and are found as storage polysaccharide in various plants. -mannanases are the main mannan degrading enzymes. In this work the -1,4-mannanase from the soilliving bacteria Cellulosamas Jimi was studied and special focus was put on

COSB45 Literature List 2025

COSB45: Social Movements in East and South-East Asia Literature List Literature Introduction COSB45 is a first-cycle elective course offered by the Centre for East and South-East Asian Studies and open to general enrolment. The course is a distance course, which provides a thorough overview of a comprehensive overview of social movements in East and South- East Asia. It comprises issues including

https://www.ace.lu.se/sites/ace.lu.se/files/2024-12/COSB45%20literature%20list%202025.pdf - 2026-06-02

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1a. Vilka av följande samtal har du haft under lönerevisionen 2024? Du kan välja flera alternativ. Sida 2 - Fråga 1 | A. Inledande frågor Pr oc en t Series Samtal 1 (prestationssamtal) Samtal 2 (lönesamtal) Samtal 3 (bekräftelsesamtal) Övriga/ytterligare samtal Nej. Jag hade inga Lönesättande samtal. Lönen bestämdes ensidigt av min chef. 0 20 40 60 80 100 enkat_om_lonerevisionen_2024_sv 2. Hur fic

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/slu/dokument/enkat_om_lonerevisionen_2024_sv.pdf - 2026-06-02