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Several risk factors for severe non-proliferative and proliferative retinopathy in type 1 diabetes mellitus have been proposed without explaining the rapid progression of retinopathy in some patients. Since GAD65 autoantibodies (GAD65Abs) are detected against glutamic acid decarboxylase (GAD), which is mainly expressed in islets and nervous tissue in type 1 diabetic patients, the aim of the presen
Superporous agarose beads were used as a support for hydrophobic interaction chromatography. These beads have large connecting flow pores in addition to their normal diffusion pores. The flow pores, which are approximately one fifth of the overall diameter of the superporous agarose beads, were earlier shown to give the beads improved mass transfer properties relative to homogeneous agarose beads
Weak alignment of requirements engineering (RE) with verification and validation (VV) may lead to problems in delivering the required products in time with the right quality. For example, weak communication of requirements changes to testers may result in lack of verification of new requirements and incorrect verification of old invalid requirements, leading to software quality problems, wasted ef
As man-made structures are made increasingly smaller it becomes possible to conduct measurements on single cells, molecules and eventually atoms. In this thesis prerequisites for making this possible are discussed. The underlying thought is that the structures should be used in biological and organic based applications. The discussion is kept in three domains: fabrication, characterization and app
We report 43 novel genes in the water flea Daphnia pulex encoding 73 predicted neuropeptide and protein hormones as partly confirmed by RT-PCR. MALDI-TOF mass spectrometry identified 40 neuropeptides by mass matches and 30 neuropeptides by fragmentation sequencing. Single genes encode adipokinetic hormone, allatostatin-A, allatostatin-B, allatotropin, Ala(7)-CCAP, CCHamide, Arg(7)-corazonin, DENam
Objective: This study assessed the applicability and outcomes of the closure of unused cuffs in branched endovascular aneurysm repair (b-EVAR) of thoracoabdominal aortic aneurysm. Methods: We reviewed b-EVAR procedures at a tertiary referral center to identify patients who underwent incomplete branching and needed closure of the unused branch cuffs. An electronic database and intraoperative and fo
To what extent have public policies contributed to the innovation performance of Finland and Sweden in the period 1970-2013? This paper aims to assess the share of innovations stimulated by the public sector, specifically because of receiving public funding or being the result of research collaboration with public institutions. We combine survey and LBIO results on these variables, to overcome rep
The production of TMP (Trimethylolpropane) is important for many applications, and is used as alkyds in paint and lubricants among others. The reactions producing TMP consist of two major reaction chains, Aldol condensation and Cannizzaro reaction. To get a deeper understanding and improve the running conditions the kinetic expressions for the reactions were examined. The aim of this paper was to
Background: The clinical and demographic variables defining the heterogeneity of chronic obstructive pulmonary disease (COPD) are unclear. A post-hoc analysis of five randomised studies in patients with a history of previous exacerbations examined the clinical and demographic characteristics describing moderate-to-very-severe COPD. Methods: Factor analysis was performed on all continuous baseline
BACKGROUND: The current trend of upgrading undervalued agricultural by-products involves the recovery of natural antioxidants. The purpose of this study was to recover phenols from fresh olive mill wastewater (OMW) with their dispersion in 85 mL ethanol per 100 mL and to investigate the effect of processing parameters on the phenol content and antioxidant capacity of the extracts. Moreover, all th
Animal migration is a widespread phenomenon that has evolved repeatedly in a diverse set of taxa. To cope with migration, individuals express a large variety of specialized behavioural adaptations, that rely on efficient sensory systems for extraction of relevant external information. Many behaviours are visually guided, such as foraging and predator avoidance, and most migratory animals possess e
The traditional art market is currently experiencing a digital transformation and multi-sided platforms (MSPs) for trading art are a major part of this. Much research has been done in the area of MSPs, however, there is a lack of studies in the field of starting such platforms for art. Therefore, this study aims to determine the critical success factors (CSFs) for starting an online art platform (
Mål rörande rena utflyttningsskatter har det senaste decenniet varit tämligen frekvent förekommande i EU-domstolen. Detta har i sin tur medfört att, b.la, Kommissionens fokus har riktats gentemot ifrågakommande medlemsstaters utformning/tillämpning av denna typ av skatter då medlemsstaterna i sin strävan att skydda sina respektive skattebaser gärna använder sig av utflyttningsskatter i olika utforOver the last decade there has been an increase in the number of cases that are referred to the Court of Justice of the European Union (CJEU) with regards to matters of exit taxes. Consequently, this has turned the Commission’s focus towards the outline of the respective exit tax regimes applied in the different Member States (MS). This since the MS, in their efforts to protect their respective ta
Popular science Temporal variation of soil respiration at Skyttorp Soil respiration (Rs) is a major component of carbon fluxes from terrestrial biosphere to the atmosphere with contributing 30-80% of annual total ecosystem respiration in forests. Rs, refers to the production of CO2 from soil by respiration of root and microorganisms, is normally demonstrated by soil CO2 flux in the unit of μmol m
In this work, different solutions for human presence detection in a door intercom device are examined. The study was conducted at a company in Lund, Sweden. The aspiration was to have a reliable presence detection to be able to put the device in sleep mode when not used, and the current solution is not optimal because of limiting design requirements and false triggers. In the project, several diff
As time is moving forward, the world is becoming more dependent on Internet of Things (IoT) devices. The vision for the future involves IoT devices participating in various aspects of our daily lives, including sensing, controlling, and communicating. Such a future requires a significant number of IoT devices, which raises questions regarding sustainability in terms of battery waste. One promising
Background: Neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as the most promising biomarker of acute kidney injury. However, there are no reliable data on analytical sensitivity and reference limits of urinary NGAL (uNGAL) assay in pediatric age. The aim of the present study is to evaluate the analytical sensitivity and the reference range of uNGAL measured in urine specimens
Att säkra tillgång till patentskyddade medicinska produkter, särskilt livsnödvändiga läkemedel rörande HIV/AIDS och andra epidemiska sjukdomar, har varit i fokus för en global juridisk debatt under många år. Denna debatt intensifierades ytterligare efter tillkomsten av TRIPS-avtalet och den globala verkställigheten av immaterialrätter såsom patent genom Världshandelsorganisationen (WTO). Många NThe issue of securing access to patented pharmaceutical products, especially essential medicines in the field of HIV/AIDS and other epidemic diseases, has been in the forefront of global legal debate for many years. This debate intensified further following the enactment of the TRIPS agreement and the global enforcement of Intellectual Property Rights such as patents through the World Trade Organi
Glutathione peroxidase activity (GSHPx), total and soluble selenium in two muscles from five species were compared (chicken, duck, turkey, ostrich and lamb). The highest GSHPx activity, found in duck muscles (4.8 U/g; 3.0 U/g), was significantly higher than that in lamb (1.8 U/g; 1.4 U/g), turkey (1.2 U/g; 0.6 U/g), chicken (1.0 U/g; 0.7 U/g), and ostrich muscles (0.9 U/g; 0.8 U/g). GSHPx activiti
The aim of this thesis was to reconstruct the glaciodynamics, deglacial landforms, isostatic uplift and to date the deglaciation. Glaciodynamics and deglacial landforms were focused on to provide a process and depositional model for De Geer moraine and Niemisel moraine and to reveal their internal and spatial relationship, based on detailed sedimentological and structural investigations. The isost
