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Introduction: Factor VIII activity (FVIII:C) assays of samples containing glycoPEGylated recombinant FVIII such as turoctocog alfa pegol (N8-GP) can be associated with differences in FVIII recovery in vitro between various one-stage activated partial thromboplastin time (APTT)-based clotting assays and some chromogenic assays. Careful validation and qualification of specific assays and conditions
Objective To standardize the evaluation of regional fetal brain blood perfusion, using power Doppler ultrasound (PDU) to estimate the fractional moving blood volume (FMBV) and to evaluate the reproducibility of this estimation. Methods Brain blood perfusion was evaluated in 35 normally grown fetuses at 28-30 weeks of gestation, using PDU. The following cerebral regions were included in the PDU col
This thesis presents important steps towards performing high-intensity attosecond pump-probe experiments at the Lund high-intensity extreme ultraviolet (XUV) beamline, which followed two complementary paths: maximization of the XUV intensity available in the interaction region with a gas target, and providing attosecond temporal resolution.To maximize the energy of the XUV pulses generated via hig
Objective: To assess the mid-term outcomes and feasibility of branched endovascular repair (b-EVAR) of ruptured thoracoabdominal aortic aneurysms (rTAAAs). Methods: All patients undergoing b-EVAR of rTAAAs between 2011 and 2016 were included. Pre-, intra and postoperative imaging was reviewed to assess technical success, outcomes, and feasibility of b-EVAR in the emergent setting. Results: Eleven
Here we present results from a field experiment in a sub-arctic wetland near Abisko, northern Sweden, where the permafrost is currently disintegrating with significant vegetation changes as a result. During one growing season we investigated the fluxes of CO2 and CH4 and how they were affected by ecosystem properties, i.e., composition of species that are currently expanding in the area (Carex rot
Management of foot ulcer in individuals with diabetes remains a major therapeutic challenge throughout the world. We performed a critical review of evidence of present and new techniques and devices in the treatment of diabetic foot ulcer. The golden standard for optimal evidence in the Cochrane system is level I randomized controlled trials, and meta-analyses of several randomized controlled tria
The profound impacts on human rights brought about by international and regional trade agreements have increasingly been recognized by scholars in the fields of human rights and trade, as well as international organizations and civil societies. Most notably, the intersection between human rights and trade has been reaffirmed by the United Nations, evidently in the reports by the United Nations Hig
Abstract The unprecedented fast-changing environment, embracing new information, manufacturing and process technologies in the context of the increasing globalisation of product and service market has had significant effect on the nature of work and subsequently affected career management of employees. Organizations today embark on many changes internally and externally in order to strengthen ther
Alltmedan produktionen av textiler kommit att öka under de senaste åren har dess miljöpåverkan blivit mer uppenbar. Eftersom dagens textilproduktion har negativa konsekvenser under produktion, användande, såväl som vid avfallshantering, så finns det ett behov av att hitta effektiva metoder för att ta tillvara på de resurser som investerats under produktionen. Idag förbränns eller deponeras textilaAs the production of textiles has increased over the years, the climate impact of the textile industry is becoming more evident. Textile production can have negative impacts on the environment, both during production, use and disposal, which calls for efficient recycling methods to recover some of the resources invested. However, textile waste is primarily incinerated or landfilled, which pose as
Denna uppsats syftar till att granska och kommentera den nya svenska lagen (2023:560) om granskning av utländska direktinvesteringar (direktinveste-ringslagen), som trädde i kraft den 1 december 2023. Uppsatsen övergripande syfte är att undersöka proportionaliteten av direktinvesteringslagen mot bak-grund av dess potentiella konsekvenser för förvärv av privata aktiebolag i Sverige. Syftet uppfyllsThis thesis aims to review and comment on the new Swedish Act on Screen-ing of Foreign Direct Investments (2023:560) (in this summary referred to as the FDI Act) which entered into force on 1 December, 2023. The overall purpose of the thesis is to examine the proportionality of the FDI against the backdrop of its potential consequences on acquisitions of private limited liability companies in Swed
N-Acetylneuraminic acid (Neu5Ac) is the most common form of sialic acid, a nine-carbon sugar often situated at the ends of glycoconjugates. Its unique reactivity makes it a complex substrate to work on, but new methods are continuously developed. In 2007, Ye et.al. reported a regioselective substitution by morpholine on position 4 of fully acetylated Neu5Ac, with retained stereochemistry. The anom
Realistic virtual environments offer valuable applications in rehabilitation, especially for individuals with limited mobility. However, most existing virtual reality (VR)-based rehabilitation platforms rely on procedurally generated or low-detail natural scenes, often lacking ecological and spatial authenticity. This study proposes a complete and cost-effective workflow that combines unmanned aer
Growing environmental concerns have brought a focus to the impact of building materials. In response, biobased alternatives are being explored for their potential to reduce embodied carbon, support circularity, as well as improve indoor environmental quality. This is particularly important in Scandinavia, where moisture-related issues are common, there is a growing need for locally available mater
This thesis examines how circular fashion services are made practically possible across physical and digital retail touchpoints. While circular retailing is often discussed as a strategic response to fashion’s sustainability problem, the availability of services such as repair, resale, care, and take-back does not automatically lead to participation. Drawing on social practice theory and the mater
Det akuta behovet av att mildra klimatförändringarna har lett till utvecklingen av strategier för att minska utsläppen av växthusgaser. Carbon Capture and Utilization (CCU) har vuxit fram som en lovande teknik som inte bara syftar till att fånga upp koldioxidutsläpp (CO2) utan också använder den infångade koldioxide för att skapa produkter, och därigenom tillhandahålla en potentiell väg mot hållbaThe urgent need to mitigate climate change has prompted researchers to investigate novel strategies to reduce greenhouse gas emissions. One promising technology that might ease the way for sustainable and circular economies is carbon capture and utilization (CCU), which not only captures CO2 emissions but also uses them to produce valuable products. This thesis investigates the potential of CCU i
Introduction: A grey-white matter ratio (GWR) < 1.10 at the basal ganglia level on head computed tomography (CT) previously predicted poor outcome with high specificity and moderate sensitivity in cardiac arrest patients. Data on GWR in reference populations are lacking. We explored GWR in a reference group to a cardiac arrest population and hypothesised that none would have GWR < 1.10. Methods: A
This book brings together several outstanding authors in the field and covers questions relating to the fundamental milestones in technology development and governance (Judit Sandor), an analysis of disability questions and empowerment of the community (Pin Lean Lau), right to health opportunities and challenges (Anne Kjersti Befring), the protection of the right to private life and life (Merel M.
The podocyte is a specialized cell type critically involved in maintaining the selective filtration barrier of the kidney. Podocytes are primary or secondary targets for a multitude of kidney diseases. Despite intense investigation, the transcriptome and proteome of human podocytes remain incompletely characterized. Here, we analyzed publicly available RNA-Seq data from human kidneys (n = 85) to c
