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Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR).

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

A role for PKC-epsilon in Fc gamma R-mediated phagocytosis by RAW 264.7 cells

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Recombinant factor IX Fc for the treatment of hemophilia B

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Schema mvet11 ht15 v1

Kursbeskrivning 2015-06-10 MVET11 KURSBESKRIVNING OCH SCHEMA 2015 Besöksadress Telefon dir Växel E-post Internet Tegnérsplatsen 4 046-222 0255 046-222 0200 alvar.palm@iiiee.lu.se http://www.iiiee.lu.se 221 00 Lund Internationella Miljöinstitutet, IIIEE MVET11 Strategisk Miljöutveckling 15 hp HT15 ”Smarta städer – utmaningar, möjligheter och lösningar” Kurstid: 31 augusti – 1 november 2015 Kursansv

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mvet11_ht15_v1.pdf - 2026-05-06

Schema mvet11 ht15 v2

Kursbeskrivning 2015-06-10 MVET11 KURSBESKRIVNING OCH SCHEMA 2015 Besöksadress Telefon dir Växel E-post Internet Tegnérsplatsen 4 046-222 0255 046-222 0200 alvar.palm@iiiee.lu.se http://www.iiiee.lu.se 221 00 Lund Internationella Miljöinstitutet, IIIEE MVET11 Strategisk Miljöutveckling 15 hp HT15 ”Smarta städer – utmaningar, möjligheter och lösningar” Kurstid: 31 augusti – 1 november 2015 Kursansv

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mvet11_ht15_v2.pdf - 2026-05-06

Modelling antibody orientation at bacterial surfaces

Varför gör vissa bakterier oss sjuka men inte andra? Hur kommer det sig att vissa bakterier lyckas överleva och infektera särskilda delar av kroppen men väldigt sällan andra? Bakterier och människor har evolverat länge tillsammans och har därmed lyckats utveckla specifika angrepps och försvarsmekanismer mot varandra. Det är känt sedan tidigare att några bakterier uttrycker proteiner med förmågan Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i

Inresande forskningspraktikanter

20191022 Inresande forskningspraktikanter (grund- eller masterstudenter) Den internationella kommittén vid Institutionen för psykologi har beslutat om riktlinjer för att skapa bra förutsättningar för ett ömsesidigt givande forskningssamarbete mellan inkommande forskningspraktikanter samt ansvariga forskare. Då du som forskare blir kontaktad av internationella studenter som önskar delta i ett forsk

https://www.psy.lu.se/sites/psy.lu.se/files/inresande_forskningspraktikanter.pdf - 2026-05-06

NS160-ConfPhoto

51 J ac ek D ob ac ze w sk i 52 D an ie l W ar d 53 M at th ia s S ch ad el 54 In ge m ar R ag na rs so n 55 A da m S ob ic ze w sk i 56 G ill is C ar ls so n 57 H iro m its u H ab a 58 Y uk ar i O ni sh i* 31 C la es F ah la nd er 32 M ic ha l K ow al 33 C hr is tia n Lo re nz 34 A nt on R ot h 35 R ob er t E ic hl er 36 M at ti Le in o 37 A nd re as T ur le r 38 K rz ys zt of R yk ac ze w sk i 3

https://www.particle-nuclear.lu.se/sites/particle-nuclear.lu.se/files/2023-12/NS160-ConfPhoto.pdf - 2026-05-06

Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Coins and medals

The coins and medals were sold to Lund University by the widow of Kilian Stobaeus.   COINS AND MEDALS Kilian Stobaeus’s collection of 604 coins and medals was not included in the 1735 donation. The coin cabinet was only established in 1745 when Florentina Stobaeus sold her late husband’s collection of coins and medals to Lund University. Subsequent purchases and changes to the collection make the

https://www.historiskamuseet.lu.se/stobaeus-project/coins-and-medals - 2026-05-05