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Members of the discoidin (DS) domain family, which includes the C1 and C2 repeats of blood coagulation factors V and VIII, occur in a great variety of eukaryotic proteins, most of which have been implicated in cell-adhesion or developmental processes. So far, no three-dimensional structure of a known example of this extracellular module has been determined, limiting the usefulness of identifying a
The field of molecular phylogenetics is being revolutionized with next-generation sequencing technologies making it possible to sequence large numbers of genomes for non-model organisms ushering us into the era of phylogenomics. The current challenge is no longer how to get enough data, but rather how to analyse the data and how to assess the support for the inferred phylogeny. Here, we focus on o
Remote patient monitoring should reduce mortality rates, improve care, and reduce costs. We present an overview of the available technologies for the remote monitoring of chronic obstructive pulmonary disease (COPD) patients, together with the most important medical information regarding COPD in a language that is adapted for engineers. Our aim is to bridge the gap between the technical and medica
Aiming for the sixth generation (6G) wireless communications, distributed massive multiple-input multiple-output (MIMO) systems hold significant potential for spatial multiplexing. In order to evaluate the ability of a distributed massive MIMO system to spatially separate closely spaced users, this paper presents an indoor channel measurement campaign. The measurements are carried out at a carrier
Introduction Individual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive-compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3-4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B
The objective of this study is to provide a better understanding of the potential of using Artificial Intelligence (AI) to improve Public Transport (PT), by reviewing research literature. The selection process resulted in 87 scientific publications constituting a sample of how AI has been applied to improve PT. The review shows that the primary aims of using AI are to improve the service quality o
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
Since the Rio+20 gathering in 2012, and under the banner of blue growth, heads of state, corporations, investors and environmental NGOs have been debating the oceans’ role in solving everything from world food security, to provisioning of energy and natural resources, to mitigating the impacts of climate change and ensuring improved medical care. For the ocean and its resources to play this role,
Background: The World Health Organization has adopted a resolution on sepsis and urged member states to develop national processes to improve sepsis care. In Sweden, sepsis was selected as one of the ten first diagnoses to be addressed, when the Swedish government in 2019 allocated funds for patient-centred clinical pathways in healthcare. A national multidisciplinary working group, including a pa
Open Source Software (OSS) has become an increasingly important knowledge asset in modern economies. However, the economic impact of OSS on countries’ GDP is ambivalent due to its public good character. Using a cross-country panel from 2000 to 2018, including 25 of the largest EU countries plus the USA, Japan, Korea, Canada, China, Norway, and Switzerland, matching OSS commits to GitHub to macroec
Cognitive behavioral therapy (CBT) is an efficacious therapy for youth anxiety disorders. Caregivers are key stakeholders in youth therapy, and their feedback on treatment can help to inform intervention personalization. This mixed-methods study applied a systematic inductive thematic analysis to identify themes among most- and least-liked CBT features reported by caregivers using open-ended respo
BACKGROUND: Laparoscopic surgery remains limited in low-resource settings. We aimed to examine its use in Mexico and determine associated factors.METHODS: By querying open-source databases, we conducted a nationwide retrospective analysis of three common surgical procedures (i.e., cholecystectomies, appendectomies, and inguinal hernia repairs) performed in Mexican public hospitals in 2021. Procedu
Polyphagy is an adaptative strategy allowing species to develop and survive on multiple diets. Phytophagous insects can be exposed to sub-optimal resources, as host plants vary in nutritional quality. Some insects may rely on symbiotic bacteria to better utilize less favorable substrates. The invasive fruit fly Drosophila suzukii is a highly successful pest worldwide. The use of ripening and ripe
This study examines Turkey’s agricultural sector and how it will be affected by a EU membership. Since Turkey has a great rural population and is relatively dependent on its agriculture, the implementation of the CAP will most probably affect not only the rural community, but also the specialization patterns in agriculture and the trade. The aim of this study is to estimate these changes and draw
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods:
Evolutionary changes in geographic distribution and larval host plants may promote the rapid diversification of montane insects, but this scenario has been rarely investigated. We studied the rapid radiation of the butterfly genus Colias, which has diversified in mountain ecosystems in Eurasia, Africa, and the Americas. Based on a data set of 150 nuclear protein-coding genetic loci and mitochondri
Introduction Common complications after surgical procedures include surgical site infection, wound rupture and incisional hernia. Wound healing can be influenced by the technique for abdominal access and closure. A Suture-Length to Wound-Length (SL/WLr) ratio ≥ 4 is advised to achieve a high-quality wound closure. This thesis describes the background and clinical realities of abdominal wall relat
