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Aims: The primary aim was to compare 2 years of adjuvant tamoxifen versus no systemic treatment in premenopausal patients with oestrogen receptor (ER)–positive tumours, regarding breast cancer–free interval (BCFi) and distant recurrence–free interval (D-RFi), with 30 years of follow-up and for specified intervals. Moreover, we aimed to investigate the effects of adjuvant tamoxifen on the incidence

Buildings are responsible for a third of global greenhouse gas emissions, with much of their life cycle impacts stemming from embodied impacts of building materials. Both at EU and Member State level, circular economy and resource efficiency policies are promoting production of lower-impact building materials with secondary material input. However, secondary material strategies do not result in ca

Intracortical neural probes have in the last couple of years been developed from stiff single probes to stiff multi-electrode neural probes to flexible multi-electrode neural probes. One reason for the change in design is that more than one recording/stimulation electrode, as in the case with a single wire, is needed for more advanced studies. The stiff multi-electrode probes were fabricated using

AIM: The aim of this retrospective nationwide study was to investigate indications and surgical outcome after pulmonary metastasectomy (PM) in a well-defined cohort of patients and to calculate the proportion of cancer patients who were operated on.METHODS: Between 1984 and 2008, 81 patients (age 54.8 years, 50.6% men) underwent 100 PMs with curative intent in Iceland. For all patients, informatio

Context: End-stage kidney disease (ESKD) is characterized by high physical and psychological burden, and therefore, more knowledge about the palliative care provided close to death is needed. Objectives: To describe symptom prevalence, relief, and management during the last week of life, as well as end-of-life communication, in patients with ESKD. Methods: This study was based on data from the Swe

The objectives were to evaluate possible associations between the SLC30A8 R325W polymorphism and gestational diabetes mellitus (GDM) as well as postpartum development of type 2 diabetes. Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific aut

Gaza has several water problems; limited fresh water supply, inefficient water use by the agricultural sector, high water demand, groundwater contamination, seawater intrusion and shortage of electricity. Water and electricity is the first priority for Gaza that will add significant positive values to the Palestinians living in blocked Gaza and easy operation and maintenance of their ongoing and e

Preferences of six collembolans for eight species of microfungi grown in soil have been investigated. Collembolans (Folsomia fimetaria, Isotoma anglicana, Isotama notabilis, Heteromurus nitidus, Protaphorura armata, Pseudosinella alba) and microfungi where chosen for the experiment on the basis of their abundance and vertical distribution in an organically grown field where all organisms and soil

BACKGROUND: Inversions involving intron 22 (Inv22) of F8 are detected in approximately 45% of all severe hemophilia A patients. Diagnosis is complicated by the large size of the ~9.5 kb int22h repeated sequence which generates the inversions. Methods such as long-range PCR and inverse-shifting PCR are currently used diagnostically, but suffer from low PCR efficiencies and are difficult to standard

Background: A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?. Materials and methods: Histamine SPT

I denna rapport redovisas populationstrender för 168 svenska fågelarter för åren 1975–2012. Fåglarna har räknats på vintern och på sommaren enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan 1996) men täcker hela Sverige. Vintern 2011/2012 räknades 180 000 fåglar av 134 artWe present the results of the Swedish Bird Survey, run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2012 include data from 625 winter point count routes in 2011/2012 (37th winter), of which 306 were carried out during the Christmas/New Year count and 263 summer point count routes (38th

Background: Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in triple-negative breast cancer (TNBC). However, IHC evaluation methods are non-uniform and further studies are needed to optimize clinical utility. Methods: We compared the concordance, prognostic value and gene expression between PD-L1 IHC expression by SP142 immune cell

Nature-based solutions (NBS) are actions that help communities address social-ecological challenges such as flooding and polluted groundwater. Nevertheless, research shows that in practice, NBS confront several barriers in planning and implementation, many of which are related to the different attitudes of political and administrative actors. There is knowledge missing on their viewpoints on NBS.

Analyzing the behavior of birds offers insight into the conservation of biodiversity, a heavily discussed subject in the fields of ecology as well as ornithology. As it has been previously proven (Rushton et al., 1994), slow-flowing areas of rivers represent important habitats for birds all throughout the year and the conservation of this type of habitats has been known to have a positive effect o

Background: Neurofibrillary tangle pathology is thought to drive neurodegeneration in beta-amyloid positive (A+) cognitively normal (CN) individuals, i.e., preclinical Alzheimer’s disease (AD).However, in beta-amyloid negative (A-) CN, the contribution of tau pathology [primary age-related tauopathy (PART)] to neurodegeneration remains uncertain. We investigate the correlation between tau burden m

Climate change impacts on agricultural systems are intensifying. The recent IPCC report illustrates that as temperatures climb, changes in the climate are pushing systems beyond sustainable boundaries. This is the case with certain livestock production systems (e.g. climate impacts can result in devastated supply chains or crop failures). When climate impacts are, or are projected to be, so severe

Aims: Information on standards including structure- and process-based metrics and how exercise-based cardiac rehabilitation (EBCR) is delivered in relation to guidelines is lacking. The aims of the study were to evaluate standards and adherence to guidelines at Swedish CR centers and to conduct a cost analysis of the physiotherapy-related activities of EBCR. Methods and Results: EBCR standards at

Postoperative atrial fibrillation (POAF) occurs in 20–50% of patients with coronary artery disease (CAD) after coronary artery bypass grafting (CABG). Obstructive sleep apnea (OSA) is also common in adults with CAD, and may contribute to POAF as well to the reoccurrence of AF in patients at long-term. In the current secondary analysis of the Randomized Intervention with Continuous Positive Airway

Popular Abstract in English Blood, a deep red fluid, circulates in vessels throughout our body. It consists of two main components, a liquid part and a cell part. The liquid portion, which is also called ‘plasma’, takes a main function in transporting water, nutrients, and immune substances. The cell components, which are suspended in the plasma, consist of three main cell types including platelet

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