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Protein Microarrays Based on Single Framework Recombinant Antibody Fragments (SINFABS) - Catcher and Carrier - A Crucial Combination

Popular Abstract in Swedish ?DNA-mikromatriser eller genchips? är idag väletablerade verktyg inom biologisk forskning och klinisk diagnostik. Genmikromatriser kan exempelvis användas för att i mikroskala studera genetiska skillnader mellan sjuka och friska vävnader. Informationen som då erhålls kan ge värdefulla upplysningar om sjukdomens natur och användas vid utveckling av nya läkemedel. GenernAntibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. In order to evolve the technology from small dedi

A new perspective on avian phylogeny - a study based on mitochondrial genomes

Popular Abstract in Swedish Nu levande fåglar delas traditionellt in i två grupper. Den ena gruppen är Palaeognathae och omfattar ratiter (struts, nandu etc.) och stubbstjärthöns. Den andra gruppen, Neognathae, representerar alla övriga fåglar, drygt 20 ordningar med över 9.000 arter. Grunden för denna uppdelning utgörs i första hand av morfologiska studier av fåglarnas gommar. Man har ansett att The Class Aves (birds) is generally divided into two main groups - the Palaeognathae and the Neognathae. Paleognathous birds are the flightless ratites and the tinamous, while Neognathae include all other extant birds (more than 9,000 species). This opinion has prevailed for more than a century and is primarily based on morphological studies of the avian bony palate. In this study, the relationsh

Hormone-sensitive lipase: Molecular analyses of the human gene; structural and evolutionary aspects on expression, alternative splicing and cold adaptation

Popular Abstract in Swedish Allmän Introduktion Hormonkänsligt lipas (HKL/HSL) är det protein (enzym) som hydrolyserar (bryter ner) det fett som finns lagrat inne i fettcellerna i fettväven. HSL finns också i steroidproducerande vävnader, som t.ex. binjure, äggstockar, moderkaka och testikel, och har troligtvis en viktig funktion i steroidsyntesen i åtminstone vissa av dessa vävnader. Det är dock Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. Lipolytic agents, such as catecholamines, increase the cAMP levels, resulting in an activation of cAMP-dependent protein kinase (PKA), which in turn phosphorylates and activates HSL. This thesis describes the structural orga

Crop rotations including ley and manure can promote ecosystem services in conventional farming systems

Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55

Hip Fracture Incidence and Prevalence of Osteoporosis in Sweden in Recent Decades

An increase in hip fracture incidence during the recent half-century has been reported worldwide and has been predicted to continue. Recent publications, however, have reported stable or even decreasing hip fracture incidence. No reports evaluate whether these changes in hip fracture incidence are associated with changes in bone mineral density (BMD), if they apply in both urban and rural settings

Social structures in the operating theatre: how contradicting rationalities and trust affect work.

Aim. This article is a report of a study of how healthcare professionals involved in surgery orientate themselves to their common task, and how this orientation can be affected by the social and organizational context. Background. Previous research indicates that surgical teams are not as cohesive as could be expected and that communication failures frequently occur. However, little is known abo

Preoperative vestibular ablation with gentamicin and vestibular 'prehab' enhance postoperative recovery after surgery for pontine angle tumours - first report

Conclusions. Preoperative gentamicin in combination with vestibular 'prehab' offers a possibility to reduce postoperative malaise and speed up recovery and may be used for patients undergoing such surgery when there is remaining vestibular function. Objectives. Removal of pontine angle tumours in a patient with remaining vestibular function causes symptoms of acute vestibular loss. A simultaneous

Onset of cellular instability in adiabatic H-2/O-2/N-2 premixed flames anchored to a flat-flame heat-flux burner

The onset of cellular instability in adiabatic H-2/O-2/N-2 premixed flames anchored to a heat-flux burner is investigated numerically. Both hydrodynamic instability and diffusional-thermal instability are shown to play an important role in the onset of cellular flames. The burner can effectively suppress cellular instability when the flames are close to the burner, otherwise the burner can suppres

Vascular dementia - classification and clinical correlates

Popular Abstract in Swedish Demens är ingen enhetlig sjukdom utan ett syndrom dvs en beteckning på en grupp symtom, som beskriver en långvarig försämring av hjärnans psykiska funktioner. Demens kan ha olika klinik profil och orsakas av olika skador och sjukdomar. Den vanligaste demenssjukdomen är Alzheimers sjukdom. Kring denna sjukdom finns mycket forskning gjord. Vaskulär demens är den näst vanlDuring the period (1976-1995) a total of 175 consecutive patients (m 88/f 87) with neuropathologically verified vascular dementia (VaD) were examined. 22 patients with pure Alzheimer's Disease (AD) were also studied. All patients were diagnosed and followed at the Department of Psychogeriatrics (Lund University Hospital). The neuropathological examination revealed VaD, sometimes with additional co

Comparison of the radioiodinated serum albumin (RISA) dilution technique with direct volumetric measurements in animal models of peritoneal dialysis

Background: Rat models of peritoneal dialysis (PD) are useful for studying the physiology of peritoneal transport and evaluating new osmotic agents. Intraperitoneal (IP) solute concentrations and their evolution over time are easy to measure, but IP volume (IPV) is not. Direct volumetric measurements are the "gold standard;' but they are expensive and do not allow for repetitive measurements in th

Dark-bellied Brent Geese Branta bernicla bernicla, as recorded by satellite telemetry, do not minimize flight distance during spring migration

Nine Dark-bellied Brent Geese Branta bernicla bernicla were equipped with satellite transmitters during spring staging in the Dutch Wadden Sea in 1998 and 1999. The transmitters (in all cases less than 3% of body mass) were attached to the back by a flexible elastic harness. One juvenile female was tracked to the Yamal peninsula in 1998. Eight adult males were selected from a single catch of 75 to

Trichloroethylene: Effects on body and organ weights in mice, rats and gerbils

The influence of continuous inhalation of 150 ppm trichloroethylene (TCE) on body, liver, spleen, and kidney weights in rats, mice, and mongolian gerbils was tested. An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, th

Site use by dark-bellied brent geese Branta bernicla bernicla on the Russian tundra as recorded by satellite telemetry: implications for East Atlantic Flyway conservation

In 1999, seven dark-bellied brent geese Branta bemicla bemicla were followed during spring migration from western Europe to Arctic Russia using satellite telemetry. For six of the birds we were also able to monitor their summer stay at the Taymyr Peninsula, and for five birds part of their autumn migration was recorded. In this article, we report on site use during summer and spring/autumn migrati

Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours

Introduction: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL t

Assessment of a tumour growth model for virtual clinical trials of breast cancer screening

Image-based analysis of breast tumour growth rate may help optimize breast cancer screening and diagnosis. It may improve the identification of aggressive tumours and suggest optimal screening intervals. Virtual clinical trial (VCT) is a simulation-based method used to evaluate and optimize medical imaging systems and design clinical trials. Our work is motivated by desire to simulate multiple scr

Parent's experiences of living with a child with Peadiatric Feeding Disorder: : An interview study in Sweden

IntroductionChildren affected by Paediatric Feeding Disorder (PFD) cannot consume enough nourishment by mouth. PFD is highly prevalent and can affect the child's growth and development as well as family life.AimTo illuminate Swedish parents’ experiences of living with a child with PFD.MethodSemi-structured interviews via telephone or video calls were conducted with 14 purposefully recruited mother

Behov av logistikansvarig i byggprocessen

There are only a few construction projects that include a Logistic Manager today. In many cases the profit is hard to see, since the involving tasks in logistics are the same even if there is a Logistic Manager included in the project or not. It may seem like the job is already taken care of and that a Logistic Manager therefore would be unnecessary. Even though the project tasks are the same, the

Hör, ni som har öron: En studie av samtalets funktion för nutida predikan

The purpose of this practical theological master’s thesis is to examine conversation as part of sermon preparation in present day preaching in the Lutheran Church of Sweden. This study combines studies of homiletical literature with qualitative empirical methods, stating that theory and practice informs one another. Through participant observation in Bible study groups and the following Sunday’s s

Windy Times in Emerging Economies: De-Risking Renewable Energy Investments: Case Study Vietnam

In emerging economies, high investment costs hinder fast renewable energy (RE) deployment. Compared to industrial states, higher financial costs originate mainly from investment barriers and consequently risks. Using Vietnam as a case study for emerging economies, the objective of this thesis is to identify barriers and ways to remove risks by developing a de-risking policy mix that consequently h