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MicroRNA-9-3p : a novel predictor of neurological outcome after cardiac arrest

Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and

Systemic opioid regimens for postoperative pain in neonates

Background: Postoperative pain clinical management in neonates has always been a challenging medical issue. Worldwide, several systemic opioid regimens are available for pediatricians, neonatologists, and general practitioners to control pain in neonates undergoing surgical procedures. However, the most effective and safe regimen is still unknown in the current body of literature. Objectives: To d

Systematic Augmentation in HSV Space for Semantic Segmentation of Prostate Biopsies

In recent years, the combination of the digitization of the field of pathology and increased computational power has led to a big increase in research of computer-aided diagnostics using systems based on artificial intelligence (AI). This includes detection and classification of prostate cancer, where several studies have shown great promise in automated prostate cancer grading using deep learning

Efficient nonlinear reduced order modeling for dynamic analysis of flat structures

In the present paper, strategies for reduced order modeling of geometrically nonlinear finite element models are investigated. Simulation-free, non-intrusive approaches are considered, which do not require access to the source code of a finite element program (e.g., proprietary knowledge). Our study focus on but is not restricted to flat structures. Reduction bases are generated using bending mode

Recovery, work-life balance and work experiences important to self-rated health : A questionnaire study on salutogenic work factors among Swedish primary health care employees

BACKGROUND: There is a lack of information on positive work factors among health care workers. OBJECTIVE: To explore salutogenic work-related factors among primary health care employees. METHOD: Questionnaire to all employees (n = 599) from different professions in public and private primary health care centers in one health care district in Sweden. The questionnaire, which had a salutogenic persp

Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: A meta-analysis of randomized clinical trials

BACKGROUND:Although oxygen therapy has been used for over a century in the management of patients with suspected acute myocardial infarction (AMI), recent studies have raised concerns around the efficacy and safety of supplemental oxygen in normoxaemic patients.OBJECTIVE:To synthesise the evidence from randomised controlled trials (RCTs) that investigated the effects of supplemental oxygen therapy

Tides in Colliding Galaxies

Long tails and streams of stars are the most noticeable traces of galaxy collisions. However, their tidal origin was recognized only less than 50 years ago and more than 10 years after their first observations. This review describes how the idea of galactic tides has emerged thanks to advances in numerical simulations, from the first simulations that included tens of particles to the most sophisti

Analysis of Biased Competition and Cooperation for Attention in the Cerebral Cortex

A new approach to understanding the interaction between cortical areas is provided by a mathematical analysis of biased competition, which describes many interactions between cortical areas, including those involved in top-down attention. The analysis helps to elucidate the principles of operation of such cortical systems, and in particular the parameter values within which biased competition oper

Towards diagnostic metagenomics of Campylobacter in fecal samples

BACKGROUND: The development of diagnostic metagenomics is driven by the need for universal, culture-independent methods for detection and characterization of pathogens to substitute the time-consuming, organism-specific, and often culture-based laboratory procedures for epidemiological source-tracing. Some of the challenges in diagnostic metagenomics are, that it requires a great next-generation s

Cardiovascular drug treatment, statins and biopsy-confirmed giant cell arteritis : a population-based case-control study

OBJECTIVE: To determine whether exposure to cardiovascular medications and statins is associated with increased risk of giant cell arteritis (GCA). DESIGN: The population-based case-control study comprised a cohort of patients with biopsy-confirmed GCA linked to the Swedish Prescribed Drug Register to identify all exposure to drugs prior to diagnosis of GCA. Ten controls per GCA case, matched for

Risk of colorectal cancer following CT-verified acute diverticulitis -a nationwide population-based cohort study

AIM: Routine colonoscopy to exclude colorectal cancer (CRC) after CT-verified acute diverticulitis is controversial. This study aimed to compare the incidence of CRC in acute diverticulitis patients with that in the general population. METHOD: Patients with an emergency admission for diverticular disease, to any Norwegian hospital, between January 1st , 2008 and December 31st , 2010 were included

Grammatical terminology and the application Gramte

The purpose of the Gramte program is to meet the needs of university students who feel that they are not mastering the grammatical terminology needed for studying linguistics or foreign languages. In all learning contexts it is important to have the adequate background knowledge. This is even more crucial when it concerns the basic concepts and terminology which will be used by the teachers during

Evolution of Vertebrate Eyes: a study on lens suspension and optical proterties

Popular Abstract in Swedish Alla ryggradsdjur har ögon av en typ som kallas kameraöga. Som man kan höra på namnet så fungerar ett sådant öga ungefär som en kamera. En lins fokuserar ljuset på ett ljuskänsligt lager som i ett öga kallas för näthinna (retina). De ljuskänsliga cellerna i näthinnan heter tappar och stavar. Stavarna används för seende i mörker och tapparna används för seende i starkareMany fishes have well-developed visual systems with color vision capabilities. The crystalline lens is the major refractive element in a fish eye since the cornea is optically inactive underwater. A typical fish eye has a large pupil and a lens of short focal length, features that increase light gathering ability. They lead also to short depth of focus, which makes the eye particularly susceptible

Zooplankton responses to threats from UV and predation

Ultraviolet radiation (UV) has been present longer than any biological life, and during the development of life the radiation intensities were initially high. Eventually a vital ozone layer developed, but despite that this layer screens out most of the high energy wavelengths, some still enter the biosphere and is potentially harmful to life on earth. This thesis investigates the effects of combin

Biocatalysis in Organic Media: Parameters Influencing Activity, Stability and Enantioselectivity

Biocatalysis in organic media offers very attractive methods to prepare fine chemicals. The biocatalyst performance regarding activity, stability and enantioselectivity will determine the viability of the bio-process. Therefore, the understanding and optimization of the parameters influencing enzyme performance in organic solvents are extremely important. In this thesis, reactions catalysed by hyd

Coming to Terms – The Narrativity in Sigrid Combüchen's Tale Parsifal.

The frame story
takes place in a dystopian Europe, possibly some kind of European Union around 2050 – in a state of conflicts and decay. The protagonists are a retired general, Piscator (cf. Fisher King) and a former journalist, Perle Vaus (cf. Perlesvaus/Perceval/Parsifal). She lost her home because of a new genderrelated law and stays homeless with others, covered by the Saxon bridge.

Exercising musicianship anew through soundpainting : Speaking music through sound gestures

In this thesis I focus on soundpainting-mediated musical experiences. Proposed in the mid seventies by the American musician Walter Thompson (b. 1952), soundpainting is a conventionalized artistic practice designed to create artistic works in real time. Thompson’s definition of soundpainting as a sign language is central to the present artistic inquiry, based on different moments of artistic pract

Localization of DNA damage by current exchanging repair enzymes:

Background How DNA repair enzymes find the relatively rare sites of damage is not known in great detail. Recent experiments and molecular data suggest that individual repair enzymes do not work independently of each other, but interact with each other through charges exchanged along the DNA. A damaged site in the DNA hinders this exchange. The hypothesis is that the charge exchange quickly libera

Code Division Multiple Element Synthetic Aperture Transmission

In conventional synthetic transmit aperture imaging (STA) the image is built up from a number of low resolution images each originating from consecutive single element firings to yield a high resolution image. This lowers the frame rate and may result in motion artifacts. This paper, describes a method in which all transmitting centers can be excited at the same time and separated at the receiver

A column method for determination of leaching of polycyclic aromatic hydrocarbons from aged contaminated soil

In this study a column leaching method for investigation of hydrophobic organic contaminants (HOCs) leaching from soil was developed. The method set-up is based on a recycled flow of sterile water through a soil column with a sedimentation chamber mounted on top of the column, in connection with on-line filtration. The combination of a sedimentation chamber and an on-line filtration enables the me