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Resilience engineering has changed the value of expertise from meeting required standards, to how it helps organizations to adapt. This chapter discusses the origin of the concept of resilience and how it has been applied to sociotechnical systems within the safety domain. From there we review the current literature to explore how to manage expertise, considering both its possible good and bad eff
Conductive Electric Road Systems (ERS) appear as a promising solution for the electrification of transportation, particularly for heavy vehicles and long-distance trips but also for light vehicles. Significant research efforts are currently devoted to the development of conductive ERS systems, with up to four pilot test sites with different technologies in operation only in Sweden. With the help o
Recent advances in therapeutics are now providing a wide range of options for adults and children living with hemophilia. Although therapeutic choices are also increasing for the youngest individuals with severe disease, challenges remain about early management decisions, as supporting data are currently limited. Parents and healthcare professionals are tasked with helping children achieve an incl
Background and purpose — The annual number of total knee arthroplasties (TKAs) has increased worldwide in recent years. To make projections regarding future needs for primaries and revisions, additional knowledge is important. We analyzed and compared the incidences among 4 Nordic countries Patients and methods — Using Nordic Arthroplasty Register Association (NARA) data from 4 countries, we analy
Proper and efficient renovation requires understanding the behavior of existing buildings and of different building materials. Analyzing hygrothermal measurements in two case studies, one with and the other without an internally added thermal insulation system, enabled us to identify factors of critical importance for further assessment through simulations, and to validate a hygrothermal simulatio
BACKGROUND The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking. METHODS We used nationwide Swedish demographic and health registers to follow an open population of 1
The present series comprises all families (n = 77) with haemophilia B in Sweden and may be considered to be representative for the purposes of a population-based study of mutational heterogeneity. The 77 families (38 severe, 10 moderate, 29 mild) had 51 different mutations in total. Thirteen families had total, partial or small deletions, two had mutations in the promoter, eight families had splic
Background: Current information on the role of internists in the European countries is scarce. This report describes the results of a survey of the practice of internists in Europe. Methods: Two online questionnaire-based surveys were carried out by the European Board of Internal Medicine, one on the practice of internists and the other on postgraduate training in internal medicine. The national i
This study evaluated the effects of retinal ischemia-reperfusion (IR) injury and pre-treatment with the potent and specific aldose reductase inhibitor fidarestat on apoptosis, aldose reductase and sorbitol dehydrogenase expression, sorbitol pathway intermediate concentrations, and oxidative-nitrosative stress. Female Wistar rats were pre-treated with either vehicle (N-methyl-D-elucamine) or fidare
Background: Exhaled breath temperature (EBT) has been suggested as a marker of airway inflammation in asthma. Objectives: The aim of the present study was to investigate EBT in asthmatic subjects compared to healthy controls after an exercise challenge test, and in subjects with exercise-induced bronchoconstriction compared to subjects without, and to compare with body temperatures. Methods: A tot
Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. The red blood cells are responsible for transporting oxygen throughout the body, while the myeloid and lymphoid cells are essentially required for immune responses. The HSCs reside in special niches in t
Background To evaluate the effects of a case management intervention for frail older people (aged 65+ years) by cost and utility. Materials and methods One hundred and fifty-three frail older people living at home were randomly assigned to either an intervention (n = 80) or a control group (n = 73). The 1-year intervention was carried out by nurses and physiotherapists working as case managers, w
PURPOSE: To evaluate patients' vision-related activity limitation before and after bilateral cataract surgery using the German version of the Catquest-9SF questionnaire. SETTING: Hanusch Hospital, Vienna, Austria, and Ophthalmic Clinic, Minden, Germany. DESIGN: Questionnaire development. METHODS: This prospective 2-center study included patients who were scheduled for bilateral cataract surgery an
Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and
Background In ST-elevation myocardial infarction (STEMI), distal embolization of thrombus material often precludes restoration of normal coronary artery flow. Small-scaled studies have demonstrated that intracoronary thrombus aspiration improves flow and myocardial perfusion, but only one larger randomized single-center study has suggested a survival benefit. Thrombus aspiration is widely used in
The balance of intestinal microbiota, which is present in health, can be affected by severe illness and antibiotics. Pathogenic bacteria, which are usually suppressed by the commensal flora, may multiply and can cause complicating secondary infections. Administration of probiotics can help to reduce the deleterious effects of disease and antibiotics in critically ill patients: they can improve gut
The electroencephalography (EEG) signal has a high complexity, and the process of extracting clinically relevant features is achieved by visual analysis of the recordings. The interobserver agreement in EEG interpretation is only moderate. This is partly due to the method of reporting the findings in free-text format. The purpose of our endeavor was to create a computer-based system for EEG assess
Objective: The proteoglycan decorin stabilizes collagen whereas biglycan and hyaluronan disrupt well-organized collagen. The aim was to compare hyaluronan and proteoglycans in human fetal membranes obtained before and after spontaneous labour at term. Study design: Prelabour samples of fetal membranes (N = 9) were obtained from elective caesarean sections and regionally sampled from over the cervi
Abstract in French L’étude de l’effet d’amorçage syntaxique (syntactic priming) permet d’examiner la relation (potentielle) entre input et output dans l’interaction. On observe un effet d’amorçage lorsque la présentation d’un item (l’amorce) facilite le traitement ultérieur d’un item similaire (la cible). L’amorçage syntaxique ou structurel est un phénomène de réutilisation de la structure syntaxi
OBJECTIVE: To determine moment arm lengths from seven knee muscles and the patellar tendon. The knee muscles were the biceps femoris, semitendinosus, semimembranosus, gracilis, sartorius, and the lateral and medial gastrocnemius muscles. DESIGN: The moment arms were calculated based on MRI measurements. BACKGROUND: Moment arm lengths of different muscles with respect to the joint centre of rotatio
