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On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations

A comparative study was performed to reveal differences and relative figures of merit of seven different calculation algorithms for photon beams when applied to inhomogeneous media. The following algorithms were investigated: Varian Eclipse: the anisotropic analytical algorithm, and the pencil beam with modified Batho correction; Nucletron Helax-TMS: the collapsed cone and the pencil beam with equ

MEASURING PSYCHOSOCIAL WORK ENVIRONMENT IN CONSTRUCTION

The study of psychosocial is highly relevant for project-based sector like construction owing to the following justifications: mobility of workers, constant change of workplace, diversity of work performed, physically demanding, high health and safety risk, meeting deadlines, monetary constraints and male-dominated industry. All these factors contribute to the industry having unique and different

Analysis of multifunctional traffic environments

The following paper is a compilation of the ongoing Swedish PhD-project “Multifunctional streets in the city - towards a more attractive city for all users and stakeholders”. In focus are arterial streets, i.e. highly multifunctional traffic environments characterized of conflicting functions, with an extensive mix of traffic modes, activities and interests. The aim of the project is to clarify an

Kinetics of human soluble and membrane-bound catechol O- methyltransferase : A revised mechanism and description of the thermolabile variant of the enzyme

Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coil and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of

Modeling Quantum Cascade Lasers : The Challenge of Infra-Red Devices

Vi lever i en tid av snabb vetenskaplig och teknologisk utveckling. För 100 år sedan hade ingen kunnat drömma om de saker som helt har förändrat vår var- dag och hur vi uppfattar omvärlden; datorer, mobiltelefoner, Internet, rymdfart, våra upptäckter om universums barndom och avlägsna galaxer samt vår insyn i kvantfenomenens mikroskopiska värld. Idag står vi på tröskeln till en era formad av nanotWe live in a time of rapid scientific and technological advancement. People liv- ing 100 years ago could never dream of inventions like those having completely changed our way of life, and our perception of the world; computers, mobile phones, the Internet, space travel, unraveling the mysteries of the early universe and distant galaxies, and our insight into the microscopic world of quantum phe-

Turbulence Modelling and Parallel Solver Development Relevant for Investigation of Gas Turbine Cooling Processes

To enhance the performance of gas turbine engines, high top-cycle temperatures are desired. However, the temperature is limited by current materials. To achieve the higher performance, and meanwhile maintain the metal temperatures of the combustors, vanes and blades below the allowable limits, sophisticated cooling techniques, such as impingement cooling, film cooling and convective internal cooli

Spatiotemporal evolution of CO2 concentration, temperature, and wind field during stable nights at the Norunda forest site

Unusually high CO2 concentrations were frequently observed during stable nights in late summer 2006 at the CarboEurope-Integrated Project (CEIP) forest site in Norunda, Sweden. Mean CO2 concentrations in the layer below the height of the eddy-covariance measurement system at 30 m reached up to 500 mu mol mol(-1) and large vertical and horizontal gradients occurred, leading to very large advective

Developing General Practice: The Role of the APO method

Abstract General practice is a broad and multifaceted field of knowledge. Political steering instruments declare that general practice and primary care are characterized by a holistic perspective on the individual, with quality, accessibility, continuity, and cooperation being important factors. For the last few decades, quality assurance has been in focus in Swedish health care. Inspiration has c

Copy number variants in the kallikrein gene cluster.

The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion

Electron reconstruction and identification efficiency measurements with the ATLAS detector using the 2011 LHC proton-proton collision data

Many of the interesting physics processes to be measured at the LHC have a signature involving one or more isolated electrons. The electron reconstruction and identification efficiencies of the ATLAS detector at the LHC have been evaluated using proton-proton collision data collected in 2011 at TeV and corresponding to an integrated luminosity of 4.7 fb. Tag-and-probe methods using events with lep

Body mass index as a predictor of fracture risk: A meta-analysis

Low body mass index (BMI) is a well-documented risk factor for future fracture. The aim of this study was to quantify this effect and to explore the association of BMI with fracture risk in relation to age, gender and bone mineral density (BMD) from an international perspective using worldwide data. We studied individual participant data from almost 60,000 men and women from 12 prospective populat

Intracellular mechanisms in rd1 mouse retinal degeneration

Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would

First stars X. The nature of three unevolved carbon-enhanced metal-poor stars

Context. On the order of 20% of the very metal-poor stars in the Galaxy exhibit large carbon enhancements. It is important to establish which astrophysical sites and processes are responsible for the elemental abundance patterns of this early Galactic population. Aims. We seek to understand the nature of the progenitors of three main-sequence turnoff Carbon-Enhanced Metal-Poor (CEMP) stars, CS 310

Kantor Triple Systems

Popular Abstract in Swedish Avhandlingens huvudsyfte är att studera reella exceptionella Kantortrippelsystem. I första artikeln visar vi först kända resultat i både de reella och komplexa klassiska fallen av K-enkla Kantortrippelsystem. I de reella klassiska fallen ger vår lösning enklare formler. Speciell uppmärksamhet ges till de reella klassiska fallen som är definierade på tensorprodukter av aThe main purpose of this thesis is to study real exceptional Kantor triple systems. In the first paper we first prove the known results in both the real and complex classical cases of K-simple Kantor triple systems. In the real classical case our approach gives somewhat simpler formulas. Special attention is given to all real classical cases of K-simple Kantor triple systems that can be presented

Genes involved in muscle contractility and nutrient signaling pathways within celiac disease risk loci show differential mRNA expression

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

The relationship between reduced renal function and cardiovascular disease

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Kardiovaskulär sjukdom (CVD) är ett i vårt samhälle växande problem där allt fler insjuknar i akuta hjärtinfarkter, stroke eller hjärtsvikt. Överlevnaden efter insjuknandet har förbättrats med åren med hjälp av nya mediciner och invasiva ingrepp såsom stentning av kranskärlen vid svår kärlkramp och direkt i det akuta skedet vid vissa tThis thesis examines the relationship between measures of renal function and cardiovascular disease (CVD) in patients with hypertension (the NORDIL study) and in the healthy population (Malmö Diet and Cancer Study, MDC) and whether antihypertensive treatment response and the risk of CVD is affected by genetic variation of a regulator of the renal amiloroide sensitive sodium channel (NORDIL). In st

The influence from the working medium on the profile loss in compressor and turbine airfoils

A number of CCS-technologies are currently being developed for the reduction of CO2 emissions from thermal power stations. One such technology is the oxyfuel process, in which a mixture of CO2 and steam is used as the working medium. The semi-closed oxyfuel combustion combined cycle (SCOC-CC) is an oxyfuel cycle where the working medium mainly consists of CO2 (85-95%). Current practice is to desig

Comparison of neuropsychological and brain imaging data in pediatric brain tumor patients surviving more than 10 years

AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are

Subsequent leukaemia in autoimmune disease patients.

Previous studies have shown that patients diagnosed with some autoimmune (AI) diseases are at an increased risk of leukaemia but limited data are available on survival. We systematically analysed the risks (standardized incidence ratio, SIR) and survival (hazard ratio, HR) in nine types of leukaemia among 402 462 patients hospitalized for any of 33 AI diseases and compared to persons not hospitali

Quantitative numerical analysis of flow past a circular cylinder at Reynolds number between 50 and 200

Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie