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BackgroundRetinal ischemia results in a progressive degeneration of neurons and a pathological activation of glial cells, resulting in vision loss. In the brain, progressive damage after ischemic insult has been correlated to neuroinflammatory processes involving microglia. Galectin-3 has been shown to mediate microglial responses to ischemic injury in the brain. Therefore, we wanted to explore th

To enhance the performance of gas turbine engines, high top-cycle temperatures are desired. However, the temperature is limited by current materials. To achieve the higher performance, and meanwhile maintain the metal temperatures of the combustors, vanes and blades below the allowable limits, sophisticated cooling techniques, such as impingement cooling, film cooling and convective internal cooli

Objectives To investigate the possible impact of maternal obesity on ultrasonographic dating of pregnancy. Methods The Swedish Medical Birth Registry was used to identify 842 083 singleton pregnancies for which the estimated date of deliver), (EDD) according to last menstrual period (EDD-LMP) and according to ultrasound examination (EDD-US) and maternal body mass index (BMI) in early pregnancy wer

We analyze a similar to 70 ks Chandra Advanced CCD Imaging Spectrometer exposure of the globular cluster omega Cen (NGC 5139). The similar to 17' x 17' field of view fully encompasses three core radii and almost twice the half-mass radius. We detect 180 sources to a limiting flux of similar to 4.3 x 10(-16) erg cm(-2) s(-1) (L-x = 1.2 x 10(30) erg s(-1) at 4.9 kpc). After accounting for the number

The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion

While only about 30% of California's usable water storage capacity lies at higher elevations, high-elevation (above 300 m) hydropower units generate, on average, 74% of California's in-state hydroelectricity. In general, high-elevation plants have small man-made reservoirs and rely mainly on snowpack. Their low built-in storage capacity is a concern with regard to climate warming. Snowmelt is expe

Objectives. Autoimmune hepatitis (AIH) is a liver disease which, if untreated, may lead to liver cirrhosis and hepatic failure. Limited data exist regarding factors predicting the long-term outcome. The aims of this study were to investigate symptoms at presentation, prognostic features, management and treatment in relation to long-term outcome of AIH. Material and methods. A cohort of 473 Swedish

We analyze cross correlations between price fluctuations of different stocks using methods of random matrix theory (RMT). Using two large databases, we calculate cross-correlation matrices C of returns constructed from (i) 30-min returns of 1000 US stocks for the 2-yr period 1994-1995, (ii) 30-min returns of 881 US stocks for the 2-yr period 1996-1997, and (iii) 1-day returns of 422 US stocks for

Popular Abstract in Swedish Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform, som ger de tekniska föInterstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas tempe

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

The climate impact of new cars in Sweden 2009 has been evaluated by the Swedish Transport Administration. Their report takes into account reduction factors to attribute the positive impact of renewable fuels on CO2 emissions. The Swedish Transport Administration recommends the public to buy cars that can run on biofuels. Besides acknowledging prevailing uncertainties for many of the input paramete

Background: beta-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP l

OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with

AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are

Constraining past changes in the strength and configuration of the geomagnetic field provides a valuable perspective on the processes that govern the geodynamo. Here we update a modelled dipole tilt reconstruction for the last 9000 years by using palaeomagnetic records that originate from globally well-distributed sites. Some features predicted by earlier dipole models become more distinct due to

Abstract Background: Velopharyngeal dysfunction (VPD) can have various causes and may be a significant disability for the affected patient. Treatment options include surgery and speech therapy, but the success rates are often inconsistent. Methods: In this study, self-assessment questionnaires were sent out to 222 Swedish patients with VPD. The questionnaire included questions about satisfaction w

The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP

Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie

Background: The risk of venous tromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of the COCs may be greater in women with preexisting thrombophilic defects. Nevertheless most women who suffer from venous thrombosis do not have any of the well known hereditary or acquired risk factors. A simple and sensitive

The objective of this study was to examine measures of insulin resistance and beta cell function in relation to ethnicity and the development of diabetes after gestational diabetes mellitus (GDM). Glucose homeostasis was assessed during a 75 g oral glucose tolerance test 1-2 years after delivery in 456 women with previous GDM (362 European, 94 non-European; including 41 Arab and 43 Asian women) an