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Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regim
Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materi
Introduction: Treatment of Graves´ disease (GD) with radioiodine increases the risk of developing Graves´ ophthalmopathy (GO), and the link between thyroid and orbital tissue may be the presence of TSH-receptors. Radioiodine increases the titers of TRAb and the aim was to investigate the relationship between GO and TRAb titers after treatment with radioiodine and to define the impact of risk genes
Background: The use of antiarrhythmic drugs (AADs) in patients with chronic kidney disease (CKD) is complex because impaired renal clearance can cause increased drug levels, and risk of intolerance or adverse events. Due to the propensity for CKD to occur alongside atrial fibrillation/atrial flutter (AF/AFL), it is essential that AAD safety and efficacy are assessed for patients with CKD. Hypothes
Scholarly journals are often blamed for a gender gap in publication rates, but it is unclear whether peer review and editorial processes contribute to it. This article examines gender bias in peer review with data for 145 journals in various fields of research, including about 1.7 million authors and 740,000 referees. We reconstructed three possible sources of bias, i.e., the editorial selection o
Cesium copper halides Cs3Cu2X5 (X = Cl, Br, and I) have attracted much attention for optoelectronic applications because of their self-trap excitons and high photoluminescence quantum yield. Intrinsic point defects play a critical role in the optoelectronic performance of these materials by affecting fundamental properties, such as carrier mobility, lifetime, and recombination rate. In this work,
BACKGROUND: Rheumatoid arthritis (RA) and the genetic risk landscape of autoimmune disorders and Parkinson's disease overlap. Additionally, anti-inflammatory medications used to treat RA might influence PD risk.OBJECTIVE: To use a population-based approach to determine if there is an association between pre-occurring rheumatoid arthritis (RA) and later-life risk of Parkinson's disease (PD).METHODS
HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our analysis uncovered (αa1, α44, α157, α196) and (β9, β30, β57, β70, β135) on the HLA-DQ molecule. The
Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on
The fields of human genetics and genomics have generated considerable knowledge about the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication, prevention and treatment – genomic-driven precision medicine (GDPM) – may help optimize medical practice. Here, we provide a comprehensive review of GDPM of complex diseases across major medical specialties. We focus on tech
The purpose of the thesis is to examine if the Swedish Central Bank, the Riksbank, reacts to changes in asset prices and the strength of the currency when regulating the short term interest rate. The application of backward- and forward-looking Taylor rules will help us evaluate the outcome of the Riksbank’s inflation forecast. The thesis is based on the Taylor rule, augmented with the deviation o
The aim of this study was to show how Swedish criminal justice agencies organizational structure is preventing and/or promoting the work with clients that are convicted. This study is based on five semi-structured interviews with five workers in the criminal justice agency. During the analyzing part the answers of the interviews were connected through Max Weber's bureaucracy theory as well as
During uncertain periods, regulators have been known to restrict the ability to short sell in markets. The stated reason is to help calm the markets and to reduce the volatility. The purpose of this paper is to examine if this stated goal was achieved by the regulators during the Eurozone crisis and the Covid-19 Pandemic, as well as comparing the impact on volatility for these two periods. This is
Mjölken som surnade Denna studie ämnar undersöka hur en organisation kan kriskommunicera på det sociala mediet Twitter, under en förtroendekris. Det bondeägda kooperativet Arla går på knäna i den rådande mjölkkrisen, trots det har det uppdagats att delar av Arlas organisation haft en osund kostnadskultur. SVTs Uppdrag granskning sände den 3 februari 2016 sitt tredje reportage kring Arla, vilket föThe soured milk The purpose of this study is to examine how an organization can crisis communicate on the social media channel Twitter during a crisis of confidence. The farmer-owned cooperative Arla is having financial trouble as the milk crisis have put a lot of the former Arla owners out of business. But in some parts of the organization, an unhealthy cost culture has been detected. On February
Support groups for children and young people whose parents abuse drugs or alcohol are a relatively new phenomenon. A major purpose of these support groups is for the participating children to understand that they are not alone in their situation. In these support groups there are also social workers whose job is to guide the children and help them understand their situation through different theme
The high surface-to-volume ratio of nanoparticles (NPs) makes them an interesting source for scientific research. How interfacial energies interplay between such a small structure and a solid bulk surface, are important because of the versatile applications NPs regard. In this thesis, a convenient and reliable method for interfacial energy determination was investigated. The interfacial energies
Titel: Den som gapar efter mycket mister ofta hela stycket – En kvantitativ studie om kvinnors påverkan på budpremien vid företagsförvärv Seminariedatum: 11 januari 2023 Kurs: FEKH89: Examensarbete kandidatnivå i finansiering, 15 högskolepoäng Författare: Sofie Andersson, Moa Nordstedt och Sofia Sjöholm Handledare: Maria Gårdängen Nyckelord: Budpremie, kvinnor, förvärv, styrelse, riskaversionTitle: Grasp all, lose all – A quantitative study of women's influence on the bid premium in business acquisitions Seminar date: 11th of January 2023 Course: FEKH89: Degree project in Financial Management, Business administration, Undergraduate level, 15 ECTS Authors: Sofie Andersson, Moa Nordstedt and Sofia Sjöholm Advisor: Maria Gårdängen Key words: Bid premium, women, acquisition, boar
Conducting a new share issue is a common way to attract new funds to a joint-stock company in need of it. By guaranteeing the new share issue the company wants to make sure that the shares are subscribed for to the largest possible extent. Guarantees play an important role as they assure the involved parties that the issue will be successful, and the using of guarantors can be crucial for several
Idiomatic expressions are abundant in the Japanese language. Probably more so than any other (although there are no official records of this; the opinions seem to differ between Mandarin, French, English and Japanese, among others). And among these idioms, there is one word that is more common than all the others. So common in fact, that it has inspired the conception of several books and articles
Swedish office buildings of the 60’s present at least 27% higher heating demand than from the current standards foreseen. This underlines their need for energy renovation. Meanwhile, office buildings are occupied during daytime, thus internal and solar gains are in phase. Consequently, such buildings could experience overheating problems. A seasonal adaptable envelope, such as a ventilated double
