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Kollektivistiska individer i en individualistisk kultur: en fenomenologisk studie om hur muslimer och jezidier från mellanöstern upplever livet i den svenska kulturen

The purpose of this study is to examine if Muslims and Jezidier from the Middle East experience changes in them self when they live in Sweden and how they feel about apply for work in the Swedish labour market. The study uses the individualistic - collectivistic dimension to describe the differences between the Swedish culture and the participants home culture. A phenomenological, theoretical and

Certifying MIP-Based Presolve Reductions for 0–1 Integer Linear Programs

It is well known that reformulating the original problem can be crucial for the performance of mixed-integer programming (MIP) solvers. To ensure correctness, all transformations must preserve the feasibility status and optimal value of the problem, but there is currently no established methodology to express and verify the equivalence of two mixed-integer programs. In this work, we take a first s

Pooled Population Pharmacokinetic Analysis and Dose Recommendations for Ciprofloxacin in Intensive Care Unit Patients with Obesity

Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for

Screening for Critical Congenital Heart Defects in Sweden

OBJECTIVES: Early diagnosis of critical congenital heart defects (CCHD) improves survival. We evaluated the relative contributions of prenatal ultrasound, neonatal pulse oximetry screening (POS), and neonatal physical examination (NPE) to the early detection (before discharge) of CCHD in the context of increasing prenatal detection, and POS being a national standard since 2013. METHODS: Retrospect

Reducing Initial Loss to Follow-up Among People With Bacteriologically Confirmed Tuberculosis : LINKEDin, a Quasi-experimental Study in South Africa

Every person diagnosed with tuberculosis (TB) needs to initiate treatment. The World Health Organization estimated that 61% of people who developed TB in 2021 were included in a TB treatment registration system. Initial loss to follow-up (ILTFU) is the loss of persons to care between diagnosis and treatment initiation/registration. LINKEDin, a quasi-experimental study, evaluated the effect of 2 in

Advocating access to justice: Facilitating or gatekeeping?

Advocacy is one of the central means for supporting access to justice. The social work profession has advocacy as one of its main courses of action. This discusses the components in actions that are considered as good practice for facilitating access to justice in its democratic aspects. More explicitly social workers advocacy for promoting the worth and dignity of human beings in society. Four di

Peer review and gender bias: : A study on 145 scholarly journals

Scholarly journals are often blamed for a gender gap in publication rates, but it is unclear whether peer review and editorial processes contribute to it. This article examines gender bias in peer review with data for 145 journals in various fields of research, including about 1.7 million authors and 740,000 referees. We reconstructed three possible sources of bias, i.e., the editorial selection o

Increased risk of Graves´ophthalmopathy in patients with increasing TRAb after radioiodine treatment and the impact of CTLA4 on TRAb titres

Introduction: Treatment of Graves´ disease (GD) with radioiodine increases the risk of developing Graves´ ophthalmopathy (GO), and the link between thyroid and orbital tissue may be the presence of TSH-receptors. Radioiodine increases the titers of TRAb and the aim was to investigate the relationship between GO and TRAb titers after treatment with radioiodine and to define the impact of risk genes

A Child-Centred Health Dialogue for the prevention of obesity : Feasibility and evaluation of a structured model for the promotion of a healthy lifestyle in preschool children and their families in the Swedish Child Health Services

Barnobesitas är sedan flera år ett ökat hälsoproblem bland barn. Obesitas vid 4 års ålder ger en kraftigt ökad risk för obesitas senare i livet. Att förebygga uppkomst och utveckling av obesitas är en långsiktig investering för framtiden. Idag finns ingen evidensbaserad metod för vägledning inom barnhälsovården för att främja hälsosamma levnadsvanor och förebygga obesitas hos förskolebarn. Det övePrevention of childhood obesity with its effects on children’s mental and physical health and well-being is an international public health priority and is suggested to be effective when started early. As Child Health Services lack an evidence-based model, there is the need for development of a low-intensive health promotion model that is feasible and cost-effective in preventing obesity in prescho

On the waiting list for joint replacement for knee osteoarthritis : Are first-line treatment recommendations implemented?

OBJECTIVE: To investigate to what extent individuals participated in guideline-based first-line treatments before being assigned to a wait list for knee replacement for osteoarthritis (OA), and to what extent they were recommended such treatments once on the list. Factors associated with participation in first-line management were also investigated.DESIGN: All patients on the waiting list ≥ three

Technological readiness and implementation of genomic-driven precision medicine for complex diseases

The fields of human genetics and genomics have generated considerable knowledge about the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication, prevention and treatment – genomic-driven precision medicine (GDPM) – may help optimize medical practice. Here, we provide a comprehensive review of GDPM of complex diseases across major medical specialties. We focus on tech

The effect of live attenuated influenza vaccine on pneumococcal colonisation densities among children aged 24–59 months in The Gambia: a phase 4, open label, randomised, controlled trial

Background Influenza and other respiratory viruses promote Streptococcus pneumoniae proliferation in the upper respiratory tract. We sought to investigate for what we believe is the first time, the effect of intranasal live attenuated influenza vaccine (LAIV) on nasopharyngeal S pneumoniae density in a low-income to middle-income country population with high pneumococcal carriage rates. Methods I

Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden

HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our analysis uncovered (αa1, α44, α157, α196) and (β9, β30, β57, β70, β135) on the HLA-DQ molecule. The

Exploring the Intrinsic Point Defects in Cesium Copper Halides

Cesium copper halides Cs3Cu2X5 (X = Cl, Br, and I) have attracted much attention for optoelectronic applications because of their self-trap excitons and high photoluminescence quantum yield. Intrinsic point defects play a critical role in the optoelectronic performance of these materials by affecting fundamental properties, such as carrier mobility, lifetime, and recombination rate. In this work,

Decreased Risk of Parkinson's Disease After Rheumatoid Arthritis Diagnosis : A Nested Case-Control Study with Matched Cases and Controls

BACKGROUND: Rheumatoid arthritis (RA) and the genetic risk landscape of autoimmune disorders and Parkinson's disease overlap. Additionally, anti-inflammatory medications used to treat RA might influence PD risk.OBJECTIVE: To use a population-based approach to determine if there is an association between pre-occurring rheumatoid arthritis (RA) and later-life risk of Parkinson's disease (PD).METHODS

How mobility restrictions policy and atmospheric conditions impacted air quality in the State of São Paulo during the COVID-19 outbreak

Mobility restrictions are among actions to prevent the spread of the COVID-19 pandemic and have been pointed as reasons for improving air quality, especially in large cities. However, it is crucial to assess the impact of atmospheric conditions on air quality and air pollutant dispersion in the face of the potential variability of all sources. In this study, the impact of mobility restrictions on

Cohort study of prediction of venous thromboembolism in emergency department patients with extremity symptoms

Despite diagnostic algorithms, identification of venous thromboembolism (VTE) in emergency departments (ED) remains a challenge. We evaluated symptoms, background, and laboratory data in 27,647 ED patients presenting with pain, swelling, or other symptoms from the extremities, and identified predictors of VTE diagnosis within one year. Predictors of a clinical decision to perform phlebography, ult

Clinical and epidemiological characteristics of Legionnaires' disease in Southern Sweden, a population-based study

BACKGROUND: The study aimed to describe all diagnosed cases of Legionnaire's disease (LD) in south Sweden, regarding incidence, patient characteristics, diagnostics, outcomes, and infection control investigations.METHODS: This population-based retrospective study was conducted in Skåne, on patients with LD between 2011-2021. Inclusion criteria were positive polymerase chain reaction (PCR) for L. p

The impact of comorbidity burden on outcomes following endovascular thrombectomy for acute ischemic stroke : A nationwide prospective observational study

Introduction: Patients with substantial comorbidity burden are underrepresented in clinical trials on endovascular thrombectomy (EVT), despite being common in clinical routine care. Therefore, analysis of observational data is needed to evaluate how increasing comorbidity burden affects procedural success rate, complication rate, and clinical outcome following EVT. Patients and methods: We conduct