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Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics (turnover of plasma/serum ARGS-aggrecan neoepitope fragments [ARGS]) of GLPG1972 in 3 randomized, double-blind, placebo-controlled phase 1 trials. Study A, a

No title

Chefernas inställning till lönesättande samtal vid Lunds universitet Rapportförfattare Adam Brenthel (PhD), ordf. Saco-S-rådets styrelse vid Lunds universitet. Statistiken och figurerna har gjorts av Roger Senden. Malin Nilsson och Helene Castenbrandt har bistått författaren. 2 INLEDNING ...............................................................................................................

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/lunds-universitet/dokument/rapporten-om-chefernas-installning-till-lonesattande-samtal-vid-lunds-universitet.pdf - 2026-04-24

Enhancing Employability Skills Through Being an SI-PASS Leader

The present survey study focuses on potential benefits of the SI-PASS experience for former Leaders in their professional life after graduating from higher education. This topic has received little attention previously with the few studies made being limited in number of participants and different in approaches used and in questions asked. The present survey was sent to 279 former SI-PASS Leaders

Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study

The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium status biomarkers in relation to overall survival and recurrence following diagnosis of primary invasive breast cancer in a large prospective cohort study. The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a prospective po

Investigating the role of lung inflammation during Mycobacterium avium colonisation

The call is coming from inside: your body’s own defences might be against you Mycobacterium avium is a species of bacteria, closely related to tuberculosis, that can cause pulmonary disease in people. Despite this, we likely come in contact with these microorganisms every day. They can be found in water reservoirs and in the soil, entering the lungs of the host – like humans and rodents – through

Impact of cerebral oxygen saturation on mortality and rehospitalisation in patients with heart failure and the role of physical activity as a modifying factor : the HARVEST-Malmö Study

BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical activ

How do Patient-reported Outcome Scores in International Hip and Knee Arthroplasty Registries Compare?

Patient-reported outcome measures (PROMs) are the only systematic approach through which the patient's perspective can be considered by surgeons (in determining a procedure's efficacy or appropriateness) or healthcare systems (in the context of value-based healthcare). PROMs in registries enable international comparison of patient-centered outcomes after total joint arthroplasty, but the extent to

Uncertainty and variation in LCA - Implementation of probabilistic methods to assess environmental impacts of infrastructures

For most applications trying to interpret the real world uncertainties will be an important factor to consider, which is also true for Life-Cycle Assessment used for estimating total environmental impact during the life-cycle of products, services, buildings, structures, roads etc. The construction and usage of infrastructure are major causes of emissions and energy use, thus making it even more i

Hur görs ledarskap? : Sakralisering i vardagliga interaktioner på en vård- och omsorgsförvaltning

Ledarskap har beskrivits som ett undflyende fenomen – en (positiv) lösning som kan kopplas till nästintill alla problem, men är svårt att fånga när det händer. Karisma, transformation och extraordinärisering utgör synsätt på ledarskap där särskilda individer tillskrivs extraordinära egenskaper, men de har inte fångat hur detta görs i vardagliga interaktioner. Ledarskap som praktik och ledarskap i Leadership has been described as a disappearing phenomenon – a (positive) solution that can be attached to almost any problem, yet it is difficult to capture as it happens. Charisma, transformation, and extra-ordinarization are perspectives on leadership where certain individuals are ascribed extraordinary qualities, but this is not captured analytically in everyday interactions. However, Leadersh

"Odla växter och människor" - En diskursanalys av naturunderstödd rehabilitering

The aim of this study was to examine how nature-supported rehabilitation is portrayed and how the current discourses appear in a number of articles, reports and websites. The method that we used was critical discourse analysis by Norman Fairclough’s reasoning. The empirics were chosen from a targeted selection based on the purpose of the study. The distinguished discourses we found in the material

Gemensam vårdnad - en förlegad presumtion? - En rättshistorisk redogörelse av vårdnadsutvecklingen med fokus på presumtionen för gemensam vårdnad

I familjerätten finns två former av vårdnad, ensam vårdnad och gemensam vårdnad. Den sistnämnda vårdnadsformen utgör utgångspunkten vid bedömningen av vilken vårdnadsform som är lämpligast. En utgångspunkt som har varit så stark att den har gett upphov till en presumtion för gemensam vårdnad. Uppsatsen undersöker den gemensamma vårdnadens rättsutveckling med utgångspunkt i vårdnadsreformerna 199Within the area of family law there exists two forms of legal child custody, sole custody and joint custody. The last form is the starting point in court when deciding upon which form of custody constitutes the most suitable one. The strength of the previously mentioned starting point are of such degree that a presumption for joint custody took shape. The essay examines how the development of chi

Nelander et al 2009

Organization of the human embryonic ventral mesencephalon Gene Expression Patterns 9 (2009) 555–561 Contents lists available at ScienceDirect Gene Expression Patterns journal homepage: www.elsevier .com/locate /gep Organization of the human embryonic ventral mesencephalon Jenny Nelander, Josephine B. Hebsgaard, Malin Parmar * Department of Experimental Medical Science and Lund Strategic Center for

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/nelander_et_al_2009.pdf - 2026-04-24

Nurse-led geriatric clinics –The older persons perspective

Objective: The Aim of this study was to investigate older persons experience of nurse-led geriatric clinics. Design: The study was based on a qualitative method. Sample: 12 older persons (75+) were interviewed about their experience of nurse-led geriatric clinics. All participants were Swedish-speaking, varied in age and were patients from five different geriatric clinics within primary healthcare

Nationell identitet - I en globaliserad värld

In a globalized world, with ever-increasing interdependency and interconnectedness, it is often argued that political and ethical boundaries will gradually lose their significance. A cosmopolitan world order will eventually emerge, a process we, arguably, should help to bring about. However, in this paper, mainly from a communitarian perspective, I problematize this conception. The way towards thi

Analysis of the synergic and sublethal effect of the pesticides imidacloprid, acetamiprid and tebuconazole on brain metabolism in the non-bee pollinator Eristalis tenax

Abstract Introduction: A great decline of wild pollinators has been observed, the decline is believed to be a result of many stressors, whereas pesticide usage being one of them. Wild pollinator insects are significantly important to maintain and preserve food production and biodiversity. Background: Pesticides are used to protect and enhance crop yield, by targeting insect and fungi pests. Imid

Compliance by Australia with its obligations under article 18 “Liberty of movement and nationality” of the Convention on the Rights of Persons with Disabilities

While migrating to other countries, persons with disabilities often face additional obstacles as non-nationals and having a disability. Being a vulnerable group it might be hard for them to access remedies and justice. As a light in the darkness, the Convention on the Rights of Persons with Disabilities was adopted in 2006 in order to promote and protect the human rights of persons with disabiliti

Neanderthalarnas försvinnande, en diskursanalys

The perceptions of what caused the disappearance of the Neanderthals have been argued a great deal among researchers. In this paper I will present five hypotheses that different researchers have presented. Each one of these hypotheses departs from the others and stands behind either a cultural, biological or an environmental model of explanation. The aim of this thesis has been to view what the ar

Molnens påverkan på jordens strålningsbalans och klimatsystem

Molnens roll i klimatsystemet har studerats och deras påverkan på solens inverkan på jordens energibalans. Jordens albedo påverkar energibalansen genom att den påverkar hur mycket av solens instrålning som reflekteras eller absorberas. Moln påverkar jordens albedo och spelar därför en viktig roll i denna balans. Molnbildning sker till nära 100% i troposfären och där finns allt det vi kallar väder.The role of clouds in the climate system has been studied and their impact on the Sun's impact on the Earth's energy balance. The Earth's albedo affects the energy balance by influencing how much of the Sun’s radiation is reflected or absorbed. Clouds affect the Earth's albedo and therefore play an important role in this balance. Cloud formation occurs almost 100% in the tropospher

Varieties of Risk Perception and Management Among Cannabis Users - A Qualitative Study of Cannabis Cultures in Malmö, Sweden

The use of cannabis has increased in Sweden, and Malmö is one of the cities in which a big part of the inhabitants have tried the illicit drug. At the same time, the government works to increase the sanctions on cannabis use and possession. Thus, since the legislation on cannabis in Sweden is becoming more strict while a big part of Malmös citizens use cannabis, this study has aimed to investigate

An Incoherent Truth: Truth Social and democracy in our populist age

In January of 2021, the former President of the United States was banned from nearly every social media platform as a result of his actions during the January 6th attack on the U.S. Capitol. After a year of development, Trump’s company, Trump Media and Technology Group, released Truth Social, a Trump-centric social media platform, in February 2022. Although Trump’s bans from social media have most