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Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC)

Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease

Novel strategies to explore The complex genetics of autoimmune diseases

Popular Abstract in Swedish Autoimmuna sjukdomar såsom reumatoid artrit (RA) och multipel skleros (MS) uppkommer av en felaktig immunrespons mot kroppens egen vävnad. Orsaken är okänd trots enormt mycket forskning om ämnet. Ett sätt att öka kunskapen vore att identifiera de gener som bidrar till sjukdomarna. För sådana relativt vanliga, komplexa sjukdomar finns det inte en gen som ?styr? sjukdomarAutoimmune diseases are dependent on both genetic and environmental factors in complex interplay. They arise from a faulty immune response against self-antigens, and causes great suffering in affected individuals. Despite large efforts and hundreds of thousands of research articles published, the disease etiologies remain largely unknown. Knowledge of which genes are involved and how they interact

Comparative Assessment of Fuel-Based Systems for Space Heating

Replacing fossil fuels by biofuels and increasing energy efficiency are often considered to be options for reducing the net emission of greenhouse gases. This thesis presents the results of analyses of energy efficiency, emission and cost of whole energy system chains, from the natural resource to the end user when heating detached houses in a Swedish context. External costs and taxes of the energ

Appropriations of Shakespeare's King Lear in Three Modern North American Novels

This thesis examines the creative appropriation of Shakespeare in theory and practice. It is based on close readings of King Lear alongside three appropriations of the play in works of fiction by three North American women writers: Jane Smiley, Anne Tyler, and Margaret Atwood. The aim is to demonstrate how a ‘palimpsestic’ reading, i.e. a reading in which the reader oscillates between ‘pre-text’ a

Review of Language, Music, and the Brain : A Mysterious Relationship.

Reviews the book, Language, Music, and the Brain: A Mysterious Relationship by Michael A. Arbib (2013). For the researcher, or for anyone interested in research using a multidisciplinary approach to the problem of the interrelations between language, music, and the brain, this anthology is at the same time a rich “Handbook of...” and “A Companion to....” As such the book ought to be a priceless re

Recognising the Challenge: How to Realise the Potential Benefits of ICT Use in SMEs?

There is evidence to suggest that small businesses often start with innovative business ideas but fail within the first 3 years because the proprietors lack the expertise to make them thrive. In this context, it has been suggested that SMEs would benefit from support to select suitable ICTs that can help them to make the most of their business potential. Such suggestions tend to overlook a need to

Conceptions, Categories, and Embodiment: Why Metaphors are of Fundamental Importance for Understanding Norms

The propositions in this chapter are to a large extent drawn from the thesis Metaphors and norms – understanding copyright law in a digital society (Larsson 2011b), however with some important complements, not least concerning the implications of categorisation. The chapter is explorative in bringing findings from cognitive linguistics into the quite common socio-legal task of studying norms. Its

Occurrence of cold sensitivity in carpal tunnel syndrome and its effects on surgical outcome following open carpal tunnel release

Cold sensitivity is common following nerve injuries in the upper extremity, but is less well studied in carpal tunnel syndrome (CTS). We investigated cold sensitivity in CTS and its effects on surgical outcome. A search of the Swedish National Registry for Hand Surgery (HAKIR) for open carpal tunnel releases (OCTR) from 2010–2016 identified 10,746 cases. Symptom severity questionnaires (HQ-8; HAKI

Nutritional status and outcome of surgery : A prospective observational cohort study of children at a tertiary surgical hospital in Harare, Zimbabwe

Background: Undernutrition contributes to nearly 50% of all child deaths in the world, yet there is conflicting evidence regarding the association between nutritional status and postoperative complications. The aim was to describe the preoperative nutritional status among pediatric surgery patients in Zimbabwe, and to assess if nutritional status was a risk factor for adverse postoperative outcome

Management and risk of mortality in patients hospitalised due to a first severe COPD exacerbation

Background: Reducing the need for hospitalisation in patients with chronic obstructive pulmonary disease (COPD) is an important goal in COPD management. The aim of this study was to evaluate re-hospitalisation, treatment, comorbidities and mortality in patients with COPD who were hospitalised for the first time due to a COPD exacerbation. Methods: This was a retrospective, population-based observa

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case–control pairs from 20 prospective cohorts included in the inte

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Background: The mandibular symphysis is a true joint with a fibrocartilage disc stabilizing both ramus of mandible. The mandibular fracture occurs in 15% of all cases of fracture in cats, and of these, 73% correspond to fracture of the mandibular symphysis. There is a technique for stabilization of symphysis fracture using a nylon cable tie band, however it is necessary to perform two lateral inci

Time Trends and Monthly Variation in Swedish Acute Stroke Care

Background and Purpose: Studies of monthly variation in acute stroke care have led to conflicting results. Our objective was to study monthly variation and longitudinal trends in quality of care and patient survival following acute stroke.Methods: Our nationwide study included all adult patients (≥18 years) with acute stroke (ischemic or hemorrhagic), admitted to Swedish hospitals from 2011 to 201

Information transfer and medication safety for elderly patients in care transitions

Introduction: Accurate discharge summaries counteract drug-related problems due to insufficient information transfer in care transitions, but require optimal transfer and use. Careful follow-up is often essential after hospital discharge, for example when it comes to pain management in elderly patients; a common and challenging task in primary care. Aims: To assess the transfer and use of the disc

Burden of responsibility experienced by family caregivers of elderly dementia sufferers : Analyses of strain, feelings and coping strategies

Eight family caregivers of elderly dementia sufferers participated in in-depth interviews regarding their experiences of giving care. They were selected according to strain, isolation, disappointment and emotional involvement, measured on a 'caregiver burden' scale. Structural analyses of the interviews identified six categories reflecting the feelings and experiences of the caregivers. The first

Leadership Challenges in Academia : Four Case studies

This thesis is an exploration of leadership dimensions of academic organisational processes. It consists of four case studies, each presenting a leadership challenge. These studies of specific situations offer great opportunities to investigate the variety of leading that the academy contains. There is focus, not so much on the task but on the process in which the challenges are positioned, how th

An organizational study into the concept of automation in a safety critical socio-technical system

Although automation has been introduced in all areas of public life, what seems to be missing is a reflection at the organizational or societal level about a policy of automation. By this we intend appropriate declarations made at the level of rationale, future plans and strategies to achieve intended goals and most importantly how those achievements will impact on various aspects of societal life

Causes and contributing factors of maternal mortality in Bosaso District of Somalia. A retrospective study of 30 cases using a Verbal Autopsy approach

Background: Somali women suffer from one of the highest maternal mortality rates in the world. Somalia characterises a specific low-income country situation with a mix of newly urbanized and nomadic culture combined with a frail health care infrastructure set in a post-conflict era. Very little is known about the effects that these contextual factors can have on maternal mortality. Objectives: To

Ray Accelerator : Efficient and Flexible Ray Tracing on a Heterogeneous Architecture

We present a hybrid ray tracing system, where the work is divided between the CPU cores and the GPU in an integrated chip, and communication occurs via shared memory. Rays are organized in large packets that can be distributed among the two units as needed. Testing visibility between rays and the scene is mostly performed using an optimized kernel on the GPU, but the CPU can help as necessary. The

Exome sequencing of contralateral breast cancer identifies metastatic disease

Women with contralateral breast cancer (CBC) have significantly worse prognosis compared to women with unilateral cancer. A possible explanation of the poor prognosis of patients with CBC is that in a subset of patients, the second cancer is not a new primary tumor but a metastasis of the first cancer that has potentially obtained aggressive characteristics through selection of treatment. Exome an