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Popular Abstract in Swedish Cystisk fibros (CF) är en ärftlig sjukdom som orsakas av en defekt jonkanal. Denna defekt ger upphov till en onormal saltbalans i kroppen och följderna blir många. I lungorna och magtarmkanalen produceras ett väldigt segt slem vilket täpper till luftvägarna och medför andningssvårigheter. De slemfyllda lungorna klarar inte av att transportera upp slemmet och istället stCystic fibrosis is an inherited disease, caused by mutations of the cystic fibrosis transmembrane conductance regulator gene. The gene codes for a protein that serve as chloride channel. In cystic fibrosis, this protein is lacking or has a defect function resulting in a thick and sticky mucus of the airways. The altered airway environment promotes mucus and growth of pathogenic bacteria. A common

During the prolonged course of chronic viral infection there is a continuous reciprocal interaction between the host immune defence system and the viral immunogens, and viral genetic mutations capable of circumventing host immune defence could be selected for. Our observation of increasing prevalence of heterogeneity in the DNA sequence coding for the ‘a1 determinant of HBsAg in patients with pres

Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across

Mycorrhizal symbioses are formed between plant root systems and compatible fungal hyphae that results in a complex mixed structure. They are found in all ecosystems and with the majority of land plants such as forest trees or crops that are of commercial interest. Mutual exchange of nutrients between the two symbionts is central to the successful functioning of the symbioses. In order to understan

Fjärrvärme och fjärrkyla är ändamålsenliga system för distribution av värme och kyla i tätbebyggda områden. Dessa system är viktiga vid planeringen av framtida energieffektiva system på grund av deras höga potential för att integrera förnybara energikällor. Systemen spelar också en viktig roll i samhällets energiförsörjningssäkerhet, vilket gör dem till ett tvärvetenskapligt forskningsområde. Den District heating and cooling are efficient systems for distributing heat and cold in urban areas. They are a key solution for planning future urban energy-efficient systems due to their high potential for integrating renewable energy sources. The systems also play an important role in community resilience, which makes them a multidisciplinary research topic. The continuous development of these sys

Introduction: Ischemic spinal cord injury (SCI) is a serious complication of complex aortic repair. Prophylactic cerebrospinal fluid (CSF) drainage, used to decrease lumbar cerebrospinal fluid (CSF) pressure, enables monitoring of CSF biomarkers that may aid in detecting impending SCI. We hypothesized that biomarkers, previously evaluated in traumatic SCI and brain injury, would be altered in CSF

objectives To assess effects of GH replacement therapy on cardiac structure and function, exercise capacity as well as serum lipids in elderly patients with GH deficiency (GHD). patients and methods Thirty-one patients (six females, 25 males), aged 60-79 years (mean 68 years) with GHD on stable cortisone and thyroxine substitution were studied. All men with gonadotropin deficiency had testosteron

Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerful approach for characterisation of phenotypes. Metabolomics has been used to find d

Ion beam analysis techniques are now well established as research tools for a broad range of multidisciplinary scientific fields. The ability to focus an ion beam down to micrometer size has expanded and strengthened the capability of IBA techniques to a higher level. A new field “Nuclear microprobe (NMP) analysis” has been developed over the past decades, in which most IBA techniques are used and

Aim: Head injury is the most common trauma occurring in syncope. We aimed to assess whether syncope as cause of head-trauma affects short-and long-term prognosis. Methods: From a database retrospective analysis of 97,014 individuals attending Emergency Department (ED), we selected data of patients with traumatic head injury including age, gender, injury mechanism, brain imaging, multiple traumas,

Melanoma of the skin is the sixth most common type of cancer in Europe and accounts for 3.4% of all diagnosed cancers. More alarming is the degree of recurrence that occurs with approximately 20% of patients lethally relapsing following treatment. Malignant melanoma is a highly aggressive skin cancer and metastases rapidly extend to the regional lymph nodes (stage 3) and to distal organs (stage 4)

METHODS: This was a multicentre, international, observer-masked, randomised controlled trial of people with diabetes and a hard-to-heal foot ulcer done in 32 specialist diabetic foot clinics in three countries (UK, Denmark, and Sweden). After a 4-week run-in period, those with a reduction in ulcer area of less than 50% were randomly allocated (1:1) by computer-generated, web-based randomisation (b

Background: The Tau PET ligand 18F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer's disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of 18F -AV1451 with the tau aggregates revealed using neuropathol

Popular science summary Ortho Group SEARCH A gene is a unit of heredity of a living species. Genes are transferred from one generation to the next by vertical descent. Two genes are homologous if derived from a common ancestral gene. Homologous genes related by duplication event within the genome are paralogous genes. Copies of the same ancestral gene separated by a speciation event (when a spec

Popular science summary: Cancer is genetic disease arising due to mutations in our genome. Gene fusions are one type of mutation that has a strong impact on tumor development. They are often characteristic for specific tumor types and can therefore be used a diagnostic tool. The identification of new gene fusions have, in the recent years, been highly successful using a newly developed technique

Att förstå och att bli förstådd är avgörande för att människor inte ska missuppfatta varandra. I de fall det inte går att avläsa omgivningens reaktioner så som t.ex. på internet, är risken för feltolkningar eller missförstånd betydligt större. Om andra misstolkar eller missuppfattar det som har skrivits kan personen göra sig skyldig till brottet förtal. Om en kommentar får någon att känna sig illaTo understand and to be understood is crucial for people not to be misinterpreting each other. In those cases where it isn´t possible to read the ambient reaction such as for example, on the Internet, the risk of misinterpretation or misunderstanding is much greater. If others misinterpret or misunderstand what has been written, the person may be guilty of the offense of defamation. If a comment m

Segregation is a well-known process problem that may cost companies quality and time. The aim of this project was to establish a fundamental understanding about sifting segregation by using the sifting segregation tester described in the ASTM International standard. In this work, Cellets and Suglets were used to study particles tendency to segregate at different weight ratios and different particl

Abstract Background Axis Communications is a Lund based company which specializes in network cameras. In addition to the cameras, the company has a wide range of accessories that ensure their customers receive complete solutions. While the company has had significant successes by investing heavily in R&D, increased competition from low-cost competitors is now placing higher demands on cost-eff

Implementation av ozonering som teknik på avloppsreningsverk är en av de lösningar som har visat sig effektiv för att avlägsna läkemedelsrester och andra mikroföroreningar och förhindra att de hamnar i naturliga vattendrag. Uppkomsten av transformationsprodukter till följd av ozonering och hur väl ett efterföljande biologiskt reningssteg kan ta hand omdem ett område där mer kunskap behövs. I dettaThe implementation of ozonation technology in sewage treatment plants is a solution that has proven efficient in removing residual pharmaceutical substances and other micropollutants to prevent their spreading in natural water bodies. The appearance of transformation products originating from micropollutants as a result of ozonation, and how well biological post treatment can remove these is a res