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Objective: To examine cause-specific mortality beyond cardiovascular diseases (CVDs) in patients with gout compared to the general population. Methods: We included all residents of Skåne (Sweden) age ≥18 years in the year 2002. Using the Skåne Healthcare Register, we identified subjects with a new diagnosis of gout (2003–2013) and matched each person with gout with 10 comparators free of gout, by
Introduction. The cure rate of early stage Hodgkin's lymphoma (HL) is excellent; investigating the late effects of treatment is thus important. Esophageal toxicity is a known side effect in patients receiving radiotherapy (RT) to the mediastinum, although little is known of this in HL survivors. This study investigates the dose to the esophagus in the treatment of early stage HL using different RT
Background: Limited data exist on transcatheter aortic valve replacement (TAVR) outcomes in patients with bicuspid aortic valve (BAV) stenosis. This study compared TAVR outcomes in BAV versus tricuspid aortic stenosis. Methods: This observational study included all patients who underwent TAVR in Sweden from 2016 to 2022, excluding those with pure aortic insufficiency and valve-in-valve procedures.
Individuals with chronic lymphocytic leukemia (CLL) face an increased risk for severe COVID-19. This study from Sweden, a country that only had a few mandatory restrictions at the onset of the pandemic, used 10 nationwide registers to compare the risks for severe COVID-19 outcomes of polymerase chain reaction-verified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections through
The laminar burning velocity (SL) of methane (CH4), the primary constituent of natural gas, is a key combustion property essential for validating combustion kinetic models. The present study focuses on the CH4 SL at the very rich side of flames, where the available experimental data are scarce with highly dispersed measurement conditions, and data projection was carried out to overcome the difficu
1(3) Saco-S-rådet PROTOKOLL Linköpings universitet fört vid styrelsemöte 2025-08-28 Styrelsen Närvarande: Krzysztof Marciniak, ITN, ordförande Peter Hult, IMT Kjell Karlsson, ITN Torbjörn Larsson, MAI Janerik Lundquist, IEI Åsa Rybo Landelius, IFM David Rule, MAI Carina Wennerholm, HMV Per Gyberg, TEMA, suppleant Maria Hedtjärn, UF, suppleant Tove Mattsson, IBL, suppleant Darcy Parks, TEMA, adjung
Popular Abstract in Swedish Njurcancer är ungefär den 10:e vanligaste tumörformen i Sverige och diagnosticeras nästan dubbelt så ofta hos män som hos kvinnor. Tumörerna upptäcks vanligtvis i åldern mellan 50 och 70 år och de mest förekommande symtomen är blod i urinen och flanksmärtor. Varför man får njurcancer är inte känt, men det finns ett klart samband med rökning och asbest. Njurcancer kan upIn the present thesis normal kidney tissue and renal cell carcinoma (RCC) were studied by cytogenetic and fluorescence in situ hybridization (FISH) methods to investigate chromosomal aberrations. In the first study, 4 samples of nonneoplastic kidney tissue were cultured for cytogenetic analysis and trisomy 7 was found in all cases in 3-15% of the cells. In the second study, cytogenetic analysis o
Popular Abstract in Swedish Prostatacancer är en av de vanligaste förekommande cancerformerna. Många äldre män har cancerceller i sin prostata, men som tur är behöver inte all cancer behandlas eftersom den inte växer. I USA får ungefär 27% av alla män prostatacancer och cirka 10% dör av det. Vi har utvecklat en ny miniatyriserad metod för att påvisa prostatacancer (Paper I). Genom att titta på PSAThe aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. The papers present two miniaturized strategies for biomarker detection, developed at the department, an antibody microarray and the ISET platform. The antibo
Inland waters were recently recognized to be important sources of methane (CH4 ) and carbon dioxide (CO2 ) to the atmosphere, and including inland water emissions in large scale greenhouse gas (GHG) budgets may potentially offset the estimated carbon sink in many areas. However, the lack of GHG flux measurements and well-defined inland water areas for extrapolation, make the magnitude of the poten
OBJECTIVE: To adapt the Knee injury and Osteoarthritis Outcome Score (KOOS) into French and to evaluate the psychometric properties of this new version. METHODS: The French version of the KOOS was developed according to cross-cultural guidelines by using the "translation-back translation" method to ensure content validity. KOOS data were then obtained in patients with symptomatic knee osteoarthrit
BACKGROUND: Consumption of soluble dietary fibre is correlated with decreased postprandial glucose and insulin responses and hence has beneficial effects on the metabolic syndrome. AIM OF THE STUDY: To investigate the effects on postprandial glucose, insulin and triglyceride concentrations of meals enriched with soluble dietary fibres from oats, rye bran, sugar beet fibre or a mixture of these thr
Long-term eddy covariance measurements of energy and water fluxes and associated climatic parameters were carried out above a Scots pine (Pinus sylvestris) forest in the middle taiga zone of Central Siberia. Data from June 1998 through October 2000 are presented. With the exception of winter 1998/1999, data collection over this period were more or less continuous. A distinct seasonality in surface
Background: Weused a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). Objective: To assess CSF BACE1 activity in AD. Design: Case-control and longitudinal follow-up
Background: The main objectives of this study were to evaluate the concordance between self-reported and registry-reported information regarding family history of breast cancer (BC), ovarian cancer (OvC) and other types of cancer in first-degree relatives of patients with early onset BC, and to determine the frequency of mutation carriers and non-mutation carriers. The secondary objective was to d
Background: Topical oestrogen and manual separation are the main treatments for labial adhesions. The aim was to evaluate treatment of labial adhesions and compare the outcome of topical oestrogen treatment with that of manual separation. Method: All girls aged 0-12 years admitted to a tertiary centre for paediatric surgery for labial adhesions were included. The study design was dual: The first p
OBJECTIVE: The brain derived neurotrophic factor (BDNF) locus has been implicated in psychiatric and substance related disorders. Recent genome-wide association studies (GWAS) have shown strong associations between single nucleotide polymorphisms in BDNF, smoking behaviour and high body mass index (BMI). Our aim was to test whether genetic BDNF variation alters the risk of smoking related morbidit
Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across
Background: Outcomes for many cancer forms are associated with socioeconomic status (SES). We investigated if SES was associated with management and mortality in men with high risk prostate cancer. Material and methods: A nation-wide population-based cohort in Prostate Cancer Data Base Sweden (PCBaSe), a merged database including data on incident prostate cancer identified in the National Prostate
Bland vilda djur finns närmast ett oräkneligt antal patogener. Dessa kan i vissa fall ge utbrott av zoonotiska sjukdomar vilket har hänt vid upprepade tillfällen under mänsklighetens historia. Men varför kan endast vissa av de patogener som normalt finns hos vilda djur infektera människor? Fågelinfluensa och West-Nile virus kan överföras från fåglar till människor medan rabies kan överföras från hParasites live on or inside their hosts and usually cause fitness loss, sometimes even lead to outbreaks of emerging infectious disease. Understanding how a parasite can infect its hosts (i.e., host specificity of the parasite) is important to both basic studies on disease evolution and the whole ecosystem health.In this thesis, I use avian haemosporidians, a group of species-rich protozoans as a
