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OBJECTIVES: To investigate whether the relative effectiveness of janus kinase inhibitors (JAKis) versus tumour necrosis factor inhibitors (TNFi) or other biological disease-modifying antirheumatic drugs in rheumatoid arthritis differ by the presence or absence of risk factors for cardiovascular (CV) disease, age, sex and smoking. METHODS: Through Swedish registers, we identified 13 493 individuals
Abstract in UndeterminedThis thesis investigates the growth and application of antimonide heterostructure nanowires for low-power electronics. In the first part of the thesis, GaSb, InSb and InAsSb nanowire growth is presented, and the distinguishing features of the growth are described. It is found that the presence of Sb results in more than 50 at. % group-III concentration in the Au seed partic
The effects of the thermal state of the body (slightly cool and neutral) and moderate wind speeds on face temperature, blood pressure, respiratory function and pain sensation during cold exposure were studied on eight healthy male subjects. They were dressed in cold-protective clothing and preconditioned at +20 °C (TN) and m5 °C (CO) for 60 min, then exposed to m10 °C and 0 m · sm1 (NoW), 1 (W1) a
BACKGROUND: Viral shedding and neutralizing antibody (NAb) dynamics among patients hospitalized with severe coronavirus disease 2019 (COVID-19) and immune correlates of protection have been key questions throughout the pandemic. We investigated the duration of reverse transcriptase-polymerase chain reaction (RT-PCR) positivity, infectious viral shedding and NAb titers as well as the association be
HPV testing has a higher sensitivity than cytology for identification of women at risk of cancer. Primary HPV testing was introduced in the organized screening program in Skåne, Sweden in 2017 for women 30 years and older. High-risk HPV E6/E7 mRNA was detected in 7.0% of these women. Primary HPV-screening identified a similar proportion of abnormal cytology (ASCUS+) as cytology-based screening (3.
Background: Despite many atrial fibrillation (AF) patients being at risk of bleeding, very limited data are available on bleeding rates of different direct oral anticoagulants based on the spectrum of bleeding risk. Objective: We aimed to compare the risk of major bleeding and thromboembolic events with apixaban vs rivaroxaban for AF patients stratified by bleeding risk. Methods: We conducted a po
UNLABELLED: Studies investigating the immunogenicity of additional COVID-19 vaccine doses in immunosuppressed patients with inflammatory rheumatic diseases (IRD) are still limited. The objective was to explore the antibody response including response to omicron virus subvariants (sBA.1 and sBS.2) after third and fourth COVID-19 vaccine doses in Swedish IRD patients treated with immunomodulating dr
The railway makes an extensive barrier in the landscape. To lower the impact of this barrier, and to allow people to easily pass it, level crossings are implemented. A level crossing is an intersection in the same plane between railway and road. Here traffic of all sorts meet with railway vehicles, which is why level crossings are one of the most distinct points of conflict in the entire railway s
Heterogena katalysatorer för användning i bränslecellssystem har undersökts baserat på aktiv fas och tillverkningsmetoder för granulat- och monolitkatalysatorer. Katalysatorerna tillverkades genom att använda θ – aluminiumoxid som bärare, dopad med lantan och cerium, där den aktiva fasen bestod av ädelmetall X och nickel i varierande halter. Analys gjordes genom att låta en blandning av vattenångaHeterogeneous catalysts to be used in a pre-reformer for fuel cell systems have been investigated based on active phase composition and catalyst preparation methods for granulate and monolithic catalysts. The catalysts were manufactured using θ – aluminum oxide as carrier, promoted with lanthanum and cerium, with active phases consisting of noble metal X and nickel in various concentrations. Analy
Research suggests that polyphenols, such as anthocyanins, that are found in considerable amounts in many types of berries, contributes with a positive effect on human cognition. However, clinical trials are warranted to support these findings. Preparation for such a trial includes developing a berry-rich study product and a corresponding reference beverage. Phenolic compounds are highly unstable a
For historical reasons, Swedish railways use 15 kV/16? Hz overhead contact lines for train traction, while the most common standard worldwide is 25 kV/50-60 Hz. This leads to higher investment costs for railway conversions and expansions, and to greater energy losses in the distribution of electricity to the trains. Yet to get away from these drawbacks by investing in a 25 kV/50 Hz overhead contac
De kommunala bostadsaktiebolagen, tillsammans med vissa stiftelser, är vad som utgör Sveriges allmännytta och är ett av kommunernas viktigaste verktyg för att främja bostadsmarknaden. Allmännyttan regleras av lagen (SFS 2010:879) om allmännyttiga kommunala bostadsaktiebolag, förkortad Allbolagen. Bolagen ska i allmännyttigt syfte främja bostadsförsörjningen i kommunen genom att erbjuda goda hyresbReal estate companies owned by Swedish municipalities, together with certain foundations, constitute what we call Allmännyttan. Allmännyttan is one of our municipalities’ most important tools for promoting public housing and is regulated by the law, abbreviated Allbolagen (SFS 2010:879). For purposes of public benefits, the municipal real estate companies are obliged to promote housing supply in t
In the coming decades, the twin energy and digital transitions will require the rapid scaling and deployment of renewable energy technologies and advanced technologies within ‘critical raw materials’ (CRMs) are essential components. At the same time, as CRM reserves are heterogeneously distributed, concentrated in a few countries with refining in even fewer still, demand is expected to outstrip su
Understanding and being able to quantify sitting postures is a central asset in car safety evaluations. This is due to the fact that passengers can choose a range of different sitting positions. Studying and understanding how passengers choose to sit to obtain some comfort is important for increased safety in futures cars and is particularly challenging facing a heterogeneous population. Data is a
Subject motion and eddy-current distortions represent significant challenges in diffusion MRI, particularly for clinical protocols utilizing "half-sphere" sampling. While the current gold standard, FSL’s eddy, employs Gaussian Process (GP) predictions to correct these artifacts, its performance can degrade under specific acquisition constraints, most notably when sampling lacks antipodal
Association for computer aided genealogy research of Sweden(DIS) is investigating the possibility of a nationwide genealogical database (RGD) of Sweden's historical population. The finished database should contain basic information about individuals' names, birth, marriage, death, and individuals' relationships such as father, mother, husband/wife and children. This will make up a kind
The purpose of this master thesis is to investigate the influencing factors on the business potential of products with health claims, using PrimaLiv as an example. And to give recommendations on how a dairy producer, which is present in the Swedish market, could improve the sales rates of products with health claims. We have chosen to put a main focus on the consumer, as he or she determines the b
Den 1 oktober 2009 trädde en de nya Takeover-reglerna i kraft. Den största nyheten i de nya reglerna var den kraftigt minskade möjligheten att erbjuda röststarka aktier ett högre pris än röstsvaga aktier i ett offentligt uppköpserbjudande. Detta är en skärpning av den aktiemarknadsrättsliga likhetsprincipen och avsikten var att tillförsäkra minoritetsägare en större del av uppköpspremien. UppsatseThe 1 October 2009 new Takeover Rules entered into force. The most material change of the new rules was that they decreased the possibility to offer multiple voting shares a higher price than ordinary shares. This is a strengthening of the legal principle of equality as applied at the Nasdaq OMX Stockholm stock market. The intention was to ensure that minority shareholders got a greater share of t
Track switches are vital parts in the railway construction. They meet an important feature when planing and stearing the traffic flow through them to increase capacity. To ensure functionality during winter they have since the 50- century systematically installed switch heating with different technical solutions but with the same objective, to keep the moving parts on the switch free from snow and
När personer i ledande ställning inom ett bolag äger stora aktieposter i bolaget brukar det tolkas som en positiv signal på de finansiella marknaderna. Samtidigt är insiders förehavanden strikt reglerade och inom EU sker detta genom marknadsmissbruksförordningen (MAR). Denna uppsats fokuserar på det så kallade handelsförbudet i artikel 19.11 MAR. Handelsförbudet innebär att personer i ledande stälA management of a company with “skin in the game”, meaning insiders owning a considerable amount of stock, is seen as a positive signal on the markets. At the same time, insider dealings is a heavily regulated area, which in the EU is constituted by the Market Abuse Regulation (MAR). The focus of this essay is on the trade prohibition in article 19.11 MAR, which stipulates that persons discharging
