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IMPORTANCE The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-calibermyelinated axons. OBJECTIVE To test whether CSF NFL concentration is associated with cognitive decline and imaging evidence of neurodegeneration and white matter

BACKGROUND: Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intratumoral levels of cholesterol and the expression of the low-density lipoprotein receptor (LDLR) to enhance our understanding of the role of the mevalonate pathway in cancer cholest

Objectives:This thesis aims to provide an overview of the epidemiology of AAV in southern Sweden, to evaluate different classification criteria in AAV. In addition we study if infection is a risk factor for later development of AAV comparing patients with AAV with a matched population cohort and to examine the occurrence of severe infections as an outcome in AAV. Methods:All adult patients diagnos

ObjectiveMepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successful real-life experiences with the approved dose for treating severe eosinophilic asthma (100 mg every 4 weeks) were observed. We undertook this study to assess the

Background: Diffusion-weighted imaging plays a key role in magnetic resonance imaging (MRI) of breast tumors. However, it remains unclear how to interpret single diffusion encoding with respect to its link with tissue microstructure. The purpose of this retrospective cross-sectional study was to use tensor-valued diffusion encoding to investigate the underlying microstructure of invasive ductal ca

Background: Real-World evidence on mesenchymal-epithelial transition exon 14 skipping mutations (METex14) in lung cancer remains limited. With an incidence of 3–4% across histological subtypes, METex14 is now an actionable target for MET inhibitors (METi) in advanced lung cancer, demonstrating response rates between 30–70%. Yet, its role in early stages and sensitivity to immune checkpoint inhibit

BACKGROUND: Health workers' (HWs') perspectives on the quality of maternal and newborn care (QMNC) are not routinely collected. In this cross-sectional study, we aimed to document HWs' perspectives on QMNC around childbirth in 12 World Health Organization (WHO) European countries.METHODS: HWs involved in maternal/neonatal care for at least one year between March 2020 and March 2023 answered an onl

Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

Improving teamwork has become a major safety goal for healthcare organizations. Audit tools currently available are useful, but they remain inadequate because they are reactive and fail to provide context for “the interaction between people and the operational context (i.e., organizational, regulatory and environmental factors) within which people discharge their operational duties” (Maurino, 2005

Integration management in Finland and Tampere is broad task including multiple actors and departments. To manage integration, is to coordinate the cross organizational cooperation of multiple service structures that support migrants with different kinds of services. Although integration work has traditionally been provided through the Employment & growth services,the other relevant services fo

Sammanfattning Examensarbetets titel: Tradition från generation till innovation - insikt i ett familjeföretags innovativa beslutfattande: En kvalitativ fallstudie om hur ett familjeföretags innovativa beslutsfattande påverkas av socioemotionella värden Seminariedatum: 30 maj 2024 Ämne/kurs: FEKH99, Examensarbete i Entreprenörskap och Innovation på kandidatnivå, 15 högskolepoäng Författare: Erik BoAbstract Title: Tradition from Generation to Innovation - Insight into a Family Business's Innovative Decision-Making: A Qualitative Case Study on How a Family Business's Innovative Decision-Making is Influenced by Socioemotional wealth. Seminar date: May 30th 2024 Course: FEKH99, Bachelor Degree Project in Entrepreneurship and Innovation Management, Business Administration, Undergraduate

This thesis aims at comparing the differences between Chinese welfare system and Swedish welfare system in respects of maternity insurance, parental leave and childcare. The reason comparing welfare system in these specific aspects is because they have intense relations with the mothers’ and children’s benefits. They also influence the mothers’ will of pregnancy. Selecting these two countries as t

I denna studie görs en livscykelanalys på en solfångare som Kristianstads Industri Service AB (KISAB) utvecklar. Även en mindre jämförelse görs med en solfångarstudie från Battisti, R (2005). KISAB:s solfångare har inga absorbatorflänsar utan den fungerar liknande en integrerad vattentank men med väldigt lite medium i den. KISAB:s solfångare består till 80 % av aluminium eftersom både absorbatorn This paper reports the result of a life-cycle analysis done on a solar thermal collector in Sweden. Kristianstad Industri Service AB (KISAB) is developing a solar thermal collector with a framework and absorbing plate made out of aluminium and no flow tubes. The aluminium is instead hollow and the whole area of the absorbing plate is therefore in contact with the coolant. The solar thermal collect

By increasing the amount of CO2 emissions to the atmosphere because of using fossil fuel and the limitation of non-renewable energy sources, solar photovoltaics technology has been growing steadily and is thought to play an important role in the realm of future energies. The objective of this thesis is to investigate the potential of the rooftops for installing PV system on a small scale of 30 mu

Background : In order to increase access to antiretroviral therapy (ART) in HIV-infected children, paediatric HIV care has been introduced in health centres in Ethiopia, where patients are managed by health professionals with limited training. Objective : To compare outcomes of paediatric HIV care in hospital and health centre clinics and to determine risk factors for death and loss to follow-up (

Syftet med examensarbetet har varit att åstadkomma en kapacitetsökning i Thom Lightings lager i Landskrona. Målet var att bestämma hur en lämplig lagerlayout med ett smalgångsalternativ skulle se ut och hur mycket kapacitetsökning denna lösning skulle åstadkomma. Ytterligare en målsättning var att se över vilka rutiner som krävs för att skapa ett effektivt lager och slutligen göra en simulering so

The purpose of this thesis project was to analyse and evaluate different systems for installation of piperun in ceilings. Main focus lay on how the systems influence the installer from an ergonomic point of view as well as productivity in terms of installation time. Several studies have been performed during this project using a variety of methods such as observations, interviews, questionnaires a

I denna rapport analyseras hur dimensioneringen av Rectiverter och UPS systemens storlek är anpassade för driftsplatsernas faktiska elförbrukning och vilka potentiella lösningar som finns för att effektivisera användandet av systemen för att minska elförbrukningen. Effektiviserandet av driftplatsernas system kommer att leda till en kostnadseffektivare anläggning. För svenska lågspänningsanläggningThis report analyzes how the size of Rectiverter and UPS systems is tailored to the actual electricity consumption at operational sites and explores potential solutions to optimize the usage of these systems in order to reduce electricity consumption. Optimizing the operational sites' systems will result in a more cost-effective facility. In Swedish low-voltage installations, a standard has be

Nutrient uptake by forest trees is dependent on ectomycorrhizal (EM) mycelia that grow out into the soil from the mycorrhizal root tips. We estimated the production of EM mycelia in root free samples of pure spruce and mixed spruce-oak stands in southern Sweden as mycelia grown into sand-filled mesh bags placed at three different soil depths (0-10, 10-20 and 20-30 cm). The mesh bags were collected

Popular Abstract in Swedish Sedimentära bergarter såsom t.ex. sandstenar och lerskiffrar, bildas genom att lösa sediment (t.ex. sand och lera) ”bakas” hårda när de sjunker ned i jordskorpan. Anledningen till att många lagerföljder rör sig nedåt i jordskorpan beror till viss del på de ovanliggande sedimentens tyngd, men är i huvudsak ett resultat av de platt-tektoniska rörelser som hela tiden påverPost-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone