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Aim: Necrotising enterocolitis (NEC) is the dominating surgical emergency in preterm neonates. The aims were to investigate indications, surgical management and mortality for surgically treated neonates with NEC. Methods: Data were retrieved from the Swedish Neonatal Quality Register for Swedish neonates with surgically treated NEC from 1 January 2017 to 31 December 2021. Diagnosis was validated b
We are traversing the growing emerging technology paradigms in today's advanced technological world. In this present era, the Internet of Things (IoT) is extensively used in all sectors. IoT is the ecosystem of smart devices which contains sensors, smart objects, networking, and processing units. These integrated devices provide better services to the end user. IoT is impacting our environment and
Background: This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden. Methods: Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demo
The Arctic is undergoing a shift toward a warmer and wetter climate. Recent experiments indicate that the carbon balance of subarctic wet tundra is sensitive to both summer warming and deeper snow. However, few studies have combined experimental data with process-oriented models to predict how the terrestrial carbon cycle will respond to future climate change. Here, we use CoupModel, a process-ori
Background: This study aimed to evaluate whether an increasing grade of obesity is associated with inferior outcomes after lumbar disc herniation (LDH) surgery. Methods: We retrieved data from the Swedish register for spine surgery regarding patients aged 20–64 who underwent LDH surgery from 2006–2016 and had preoperative and one-year postoperative data. A total of 4156 patients were normal weight
Objectives There is evidence that emergency department (ED) crowding is associated with increased mortality, however large multicenter studies of high quality are scarce. In a prior study, we introduced a proxy-measure for crowding that was associated with increased mortality. The national registry SVAR enables us to study the association in a more heterogenous group of EDs with more recent data.
Context: The global demand for food is expected to continue increasing for decades, which may drive both agricultural expansion and intensification. The associated environmental impacts are potentially considerable but will depend on how the agricultural sector develops. Currently, there are contrasting regional developments in agriculture; expansion and/or intensification in some regions and aban
Overuse of resources is accelerating today’s negative trends in climate change, ecosystem destruction, and biodiversity loss. The ultimate result is contemporary human societies are reaching or exceeding the limits of planetary boundaries. It is therefore imperative to articulate a new theoretical understanding of resources and the ethical, political and environmental conditions of their use. In t
Introduction: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) improves recurrence-free (RFS) and overall survival (OS) in patients with FIGO stage III ovarian cancer. We evaluated the effect of HIPEC on patient's health-related quality of life (HRQoL) in the OVHIPEC trial. Materials and methods: OVHIPEC was a multicentre, open-label, random
Background: Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments. Membrane proteins have several functions and are involved in numerous diseases. A large number of prediction methods have been introduced to predict protein subc
Background Little is known about the long-term outcome of anorexia nervosa.Aims To study the 30-year outcome of adolescent-onset anorexia nervosa.Method All 4291 individuals born in 1970 and attending eighth grade in 1985 in Gothenburg, Sweden were screened for anorexia nervosa. A total of 24 individuals (age cohort for anorexia nervosa) were pooled with 27 individuals with anorexia nervosa (ident
The sustainability transformation calls for policies that consider the global consequences of local lifestyles. We used stakeholders' visions of sustainable lifestyles across Europe to build 19 scenarios of sufficiency (net reductions) and 17 of green consumption (shift in consumption patterns). We applied Environmentally Extended Multi-Regional Input-Output analysis to model scenarios by assuming
Background: Emergency Department (ED) crowding occurs when demand for care exceeds the available resources. Crowding has been associated with decreased quality of care and increased mortality, but the prevalence on a national level is unknown in most countries. Method: We performed a national, cross-sectional study on staffing levels, staff workload, occupancy rate and patients waiting for an in-h
Purpose: The purpose of this study was to evaluate whether an educational palliative care intervention improved the quality of life for next of kin to older persons in nursing homes. Methods: Altogether, 90 next of kin in the intervention group and 105 next of kin in the control group were included. Data were collected using the WHOQOL-BREF questionnaire, answered before and 3 months after the int
In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of chimeric spectra or sample complexity characterization. Feature detection is difficult because of the high complexity of MS proteomics data from biologi
The aim was to assess the ability of microcosms (laboratory-scale shallow ponds) as a post polishing stage for the remediation of artificial textile wastewater comprising two commercial dyes (basic red 46 (BR46) and reactive blue 198 (RB198)) as a mixture. The objectives were to evaluate the impact of Lemna minor L. (common duckweed) on the water quality outflows; the elimination of dye mixtures,
Cerebral palsy (CP) is present in about 200 children per birth-year cohort in Sweden. From 2001 to 2016, the annual number of immigrants to Sweden with CP enrolled at the (re)habilitation services increased from less than ten to 40-90 individuals per year; about 70 % came to Sweden as refugees. At a group level, children with CP born abroad had greater functional impairment than children born in S
Objective The aim of this study was to explore the relation between the risk of first-ever stroke at working age and psychological work environmental factors. Methods A consecutive multicenter matched 1:2 case-control study of acute stroke cases (N=198, age 30-65 years) who had been working full-time at the time of their stroke and 396 sex- and age-matched controls. Stroke cases and controls answe
The overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus gThe overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus g
