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Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Deirdre B. Hobana,b, Shelby Shrigleya,b, Bengt Mattssona, Ludivine S. Bregerc, Ulla Jarla, Tiago Cardosoa,b , Jenny Nelander Wahlestedta,b, Kelvin C

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_5.pdf - 2026-07-23

Emelie Rohne EKHK18 Bachelor’s thesis (15 credits ECTS) June 2012 Supervisor: Tobias Karlsson Examiner: Benny Carlson Bachelor’s of Science Program in Development Studies Public Works Programs as a Development Strategy for Marginalized Groups: A case study of tribal MNREGA-participants in Wayanad, Kerala Abstract: In recent years, the practice of adopting Public Works Programs (PWPs) as a developm

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/emelie_rohne_bachelors_thesis.pdf - 2026-07-23

CS 22949-037 is one of the most metal-poor giants known ([Fe/H]~-4.0),and it exhibits large overabundances of carbon and nitrogen (Norris etal.). Using VLT-UVES spectra of unprecedented quality, regardingresolution and S/N ratio, covering a wide wavelength range (from lambda= 350 to 900 nm), we have determined abundances for 21 elements in thisstar over a wide range of atomic mass. The major new d

Background Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA(1c). We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabet

The increase of the consumer electronics market the last couple of decades has been one of the main drivers of IC process technology development. The majority of the ICs are used in digital applications, and for these CMOS is the choice of technology. The urge to squeeze more transistors on to a given area has led to shrinking feature sizes. It has resulted in higher transition frequencies and red

The aim of the present study was to examine mean HbA1c and blood pressure levels during a 5 year period in 442 type 1 adult diabetic patients in relation to the incidence and progression of retinopathy, nephropathy and to cardiovascular morbidity and mortality. The study showed, that in patients under routine care at a diabetic unit with four visits to the out-patient clinic per year, the intraind

Mild to moderate renal impairment affects 10% of the general population. Renal impairment is difficult to detect because of the lack of symptoms, but it can be estimated by calculating the estimated glomerular filtration rate (eGFR) on the basis of plasma creatinine and/or cystatin C concentrations. Chronic kidney disease (CKD) is associated with an increased risk of development of cardiovascular

IMPORTANCE In age-related macular degeneration (AMD), rare variants in the complement system have been described, but their functional consequences remain largely unexplored. OBJECTIVES To identify new rare variants in complement genes and determine the functional effect of identified variants on complement levels and complement regulation in serum samples from carriers and noncarriers. DESIGN, SE

Popular Science SummaryPolymers are giant molecules consisting of a repetition of many small units (monomers) that are linked together by chemical bonds. If we consider a long necklace as a polymer chain, the beads are the monomers and the part of the thread which connects the beads together is the chemical bond. Polymers are important materials in our everyday life and they can be found e.g., in This thesis incorporates studies on the aqueous systems of two types of thermoresponsive amphiphilic block copolymers; a series of nonionic triblock copolymers comprising blocks of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) denoted as PEO-PPO-PEO block copolymers, and a series of ionic diblock copolymers consisting of one charged block and one block of poly(N-isopropylacrylamide) (

Popular Abstract in Swedish Hemofili A är en form av blödarsjuka som beror på en medfödd defekt av äggviteämnet faktor VIII (FVIII). FVIII spelar en viktig roll för att kroppens blodlevringsförmåga (s.k. koagulation) ska fungera optimalt och med nedsatt funktion hos FVIII riskerar man att drabbas av allvarliga blödningar i framför allt leder, men även i muskler, slemhinnor (t.ex. näsblödning) och Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. However, approximatel

Importance Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. Objective To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Design, Setting, and Participants Population-based prospective cohort of consecutive extremely preterm infants born be

The number of supply chain disruptions has increased over the last couple of years. The Covid-19 Pandemic, blockage of the Suez Canal and Russian invasion of Ukraine are some well-known examples of disruptions. Academia seems to have noticed the increasing disruptions and has explored proactive Supply Chain Risk Management (SCRM) as an approach to address this. Consulting firms also suggest compan

After hatching, bird chicks are inevitably exposed to the thermal conditions of their environment. For the first stage of development chicks are not yet fully capable of maintaining a stable body temperature. During this time, their thermal environment can cause morphological and physiological priming. The plasticity of these responses and the extent to which they persist in the long-term is not w

BACKGROUND: Women with intellectual disabilities face significant barriers to gynecological, reproductive, antenatal, and perinatal care, which may adversely impact maternal and fetal health. Previous research indicates increased risks for gestational diabetes, pre-eclampsia, caesarean birth, preterm birth, and other complications in pregnant women with intellectual disabilities. However, studies

Oxytocin (OT) is a small neuropeptide, which is present in human plasma at extremely low endogenous levels of only a few pg/ml. It is mainly involved during labour and lactation but it has recently also been found that OT is involved in social behaviours like bonding and feeling empathy. During the last couple of years, the interest in OT has been raised and due to the matrix complexity, it is ver

SYDASIEN_2_2019_SLUTLIG_low-res.pdf På flykt efter ändrade klimatet Verklighetsfabriken Vem älskar Modi? Gatuhundar Tidskrift om Indien, Pakistan, Sri Lanka, Bangladesh, Afghanistan, Nepal, Bhutan och Maldiverna #2 2019 Sydasien.se Pris: 75 SEK 2 #2 2019 n redaktör ut, två redaktörer in. Efter nio år som redaktör för Sydasien går jag nu vidare mot nya utmaningar. Jag har i perioder önskat att jag

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/sydasien_2_2019_slutlig_low-res.pdf - 2026-07-23

The Maha Oya (river) originates in the Kandy district of Sri Lanka and travels about 130 km passing four districts to reach the sea at Kochchikade in Sri Lanka. It holds the 3rd largest average annual runoff among the 103 of distinct river basins in Sri Lanka. Its contribution as a fresh water source is of great significance. During year 2004 the river provided five percent of the total production

Development plan for the Master's programme in Environmental Studies and Sustainability Science (LUMES) Page 1 of 10 Faculty Board DEVELOPMENT PLAN Registration number STYR 2020/2030 3 February 2022 Development plan for the Master's programme in Environmental Studies and Sustainability Science (LUMES) Background In spring 2021, the Master’s Programme in Environmental Studies and Sustainability Sci

https://www.sam.lu.se/en/internal/sites/sam.lu.se.en.internal/files/2022-05/Development-plan-LUMES.pdf - 2026-07-23

The design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planneThe design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planne