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Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
2026 Gordon Research Conference on Image Science, April 26 - May 1, 2026:Leading experts in imaging will gather for five days of talks, discussions, and poster sessions, exploring cutting-edge advances across optical, MRI, X-ray, and other imaging modalities. The conference highlights innovations in instrumentation, computational methods, and AI, tackling challenging scenarios from biology to astr
https://www.fysik.lu.se/en/education/xanadu-graduate-research-school/news - 2026-07-05
FVP 2026.indd Verksamhetsplan 2026 GEMENSAMMA FÖRVALTNINGEN | LUNDS UNIVERSITET GEMENSAMMA FÖRVALTNINGENS VERKSAMHETSPLAN 2026 © Lunds universitet 2026 www.lu.se lu@lu.se TRYCK Media-Tryck, LU Service, Lunds universitet www.mediatryck.lu.se media-tryck@service.lu.se Svanenmärkt trycksak, 341903 PROJEKTLEDARE Susanne Hägerström, Utveckling FORMGIVNING Stefan Andersson, LU Service TEXTBEARBETNING Su
Nanoscience_Colloquium_2018_08_26_Zhong_Lin_lores For full program of NanoScience Colloquia see: http://www.nano.lu.se/news-and-events/nanoscience-colloquia NNAANNOOSSCCIIEENNCCEE CCOOLLLLOOQQUUIIUUMM Prof. Zhong Lin Wang Monday August 26th, 2019 at 10:15, in k-space, Fysicum Maxwell’s displacement current governed triboelectric nanogenerator for self-powered systems & blue energy Hightower Chair
https://www.nano.lu.se/sites/nano.lu.se/files/nanoscience_colloquium_2018_08_26_zhong_lin_lores.pdf - 2026-07-07
Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
Recent studies have highlighted how building resilience to ‘shrinking’ episodes, as opposed to increasing growth rates, appears to be the missing piece of the puzzle when it comes to between-country income convergence. All economies seem to be able to grow, but few countries have been able to drastically improve their shrinking patterns, which has underpinned the divergence often argued in literat
The 5-HT 7 receptor (5-HT 7 R) is involved in a broad range of physiological conditions and disorders. Currently,
Modulenthus is a company in the wood house industry that builds houses in volumes. Volume building means that Modulenthus builds predecorated house volumes in a factory and transports these to the building sites where they are being put together to complete detached houses. The purpose of these Master Thesis is that, on the basis of Modulenthus conditions and wishes, evaluate a possible using of a
