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Human igg increases virulence of streptococcus pyogenes through complement evasion
Streptococcus pyogenes is an exclusively human pathogen that can provoke mild skin and throat infections but can also cause fatal septicemia. This gram-positive bacterium has developed several strategies to evade the human immune system, enabling S. pyogenes to survive in the host. These strategies include recruiting several human plasma proteins, such as the complement inhibitor, C4b-binding prot
Elevated levels of faecal calprotectin in primary Sjögren's syndrome is common and associated with concomitant organic gastrointestinal disease.
The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
Statsvetenskap: Underrättelseanalys
Transkriberad version av Från gymnasiet till universitetet – podd med studievägledarna
I detta avsnitt blir du uppmuntrad till att vara modig och att lära känna dig själv. Avsnittet handlar också hur du ska tänka om du inte vet vad du vill studera eller jobba med. Dessutom pratar vi om varför utbildning aldrig är bortkastad tid. Välkommen till denna podd, som heter "Från gymnasiet till universitet". Om du tänker söka in på universitet eller högskola för första gången– –och är osäker
The bone morphogenetic proteins antagonist noggin inhibits membranous ossification
Bone morphogenetic proteins (BMPs) are expressed and secreted during fracture repair. Although they are likely to be required for this process, little is known about their physiological role in bone regeneration. Noggin is a protein that specifically binds and inactivates several BMPs, It plays fundamental roles during early embryonal development and limb morphogenesis by this BMP-inactivating act
The protective effect of immunoglobulin in murine tuberculosis is dependent on IgG glycosylation
Determination of carbonate-C in biochars
Although carbonate-carbon (C), an integral part of biochar-C, contributes to the liming properties of that material, it also interferes with the estimation of the stable organic C fraction in biochars. In this study, four methods were compared in order to quantify the carbonate-C in biochars: two direct (a titrimetric procedure and thermogravimetric analysis, TGA), and two indirect (acid treatment
Sommarkurser utomlands
Som student vid Lunds universitet har du möjlighet att studera vid något av våra partneruniversitet under sommaren. Genvägar till sidans innehåll:Om sommarkurser utomlandsSå ansöker duNär du har skickat in din ansökan Om sommarkurser utomlandsEn sommarkurs kan vara ett utmärkt alternativ för dig som inte vill eller kan vara borta en hel termin men som ändå vill bredda din utbildning. Ansökningsper
https://www.lu.se/student/internationella-mojligheter/sommarkurser-utomlands - 2026-05-10
Modelling antibody orientation at bacterial surfaces
Varför gör vissa bakterier oss sjuka men inte andra? Hur kommer det sig att vissa bakterier lyckas överleva och infektera särskilda delar av kroppen men väldigt sällan andra? Bakterier och människor har evolverat länge tillsammans och har därmed lyckats utveckla specifika angrepps och försvarsmekanismer mot varandra. Det är känt sedan tidigare att några bakterier uttrycker proteiner med förmågan Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i
Quality-policy-for-lund-university
Lägg till titel Page 1 of 1 REGULATORY DOCUMENT COVER PAGE Quality Policy for Lund University Type of regulatory document: Policy Definition of the type of regulatory document: Policies express the management’s overall intended direction or values that are to be taken into account within the area covered by the policy, set frameworks for a specific course of action and constitute a strong recommen
https://www.staff.lu.se/sites/staff.lu.se/files/2025-02/quality-policy-for-lund-university.pdf - 2026-05-10
Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI)
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality and can occur with any type of transfusion. TRALI is thought to be primarily mediated by donor antibodies activating recipient neutrophils resulting in pulmonary endothelial damage. Nonetheless, details regarding the interactions between donor antibodies and recipient factors are unknown. A murine a
Studies on Neuropsychiatric Manifestations and Genetic Factors in Systemic Lupus Erythematosus
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou
Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest
BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p
INTONAL 2026: Acousmatic Concerts at IAC
22 april 2026 17:00 till 26 april 2026 20:00 | Konsert, Övrigt Welcome to a new edition of INTONAL Festival at IAC! For the 2026 edition, we have shaped a curatorial framework that brings together our 15-years tradition of acousmonium practice and a focus on South and Central American sound scenes. This perspective unfolds through a dedicated talk and curated concerts, with music spatialized live
https://www.lu.se/evenemang/intonal-2026-acousmatic-concerts-iac - 2026-05-10
Behandling av personuppgifter vid Lunds universitet
Lunds universitet hanterar personuppgifter för att kunna erbjuda utbildning, bedriva forskning och samverka med det övriga samhället. All behandling av personuppgifter inom universitet har som syfte att understödja detta uppdrag. Universitetet tillämpar dataskyddsförordningen (den engelska benämningen är "General Data Protection Regulation", ofta förkortad GDPR) med kompletterande lagstiftning.Van
https://www.lu.se/om-universitetet/kontakta-oss/behandling-av-personuppgifter-vid-lunds-universitet - 2026-05-09
Forskargruppen för oftalmologisk avbildning
Genom att kombinera kunskapen från kliniskt aktiva läkare och forskare tror vi att vi snabbt och effektivt kan få kunskap om de spektrala egenskaperna hos hudcancer och jättecellartrit och översätta detta till avbildningsverktyg för detektion av tumörgränser och diagnostik. Genom att mäta blodflöde under och efter periorbital rekonstruktiv kirurgi strävar vi efter att uppdatera kirurgiska teknikerBy combining the knowledge of clinically active medical doctors and researchers we believe that we can rapidly and effectively gain knowledge on the spectral properties of skin cancer and giant cell arthritis and translate this into imaging tools for tumor border outlining and diagnosis. Through monitoring of blood flow perfusion during and following periorbital reconstructive surgery we aim to up
Tissue response of radiation therapy assessed by electrical impedance spectroscopy (EIS) in subcutaneous tumours in rats.
Föreliggande undersökning syftar till att utvärdera möjligheten att använda bioimpedansspektrometri för att mäta tumör- och vävnadsrespons på strålterapi. Bioimpedansmätningar utförda med CythorLab ™ utrustade med en signalgenerator med en känd högutgångsimpedans och signalmätanordning som kan mäta spänningen som appliceras av generatorn. Styrenheten utlöser signalgeneratorn som genererar en MLS-sThe present investigation aims to evaluate the possibility of using bio-impedance spectrometry to measure tumour and tissue response to radiation therapy. Bio -impedance measurements performed with CythorLab™ equipped with a signal generator with a known high output impedance and signal measuring device able to measure the voltage applied by the generator. The control unit triggers the signal gene
