Sökresultat

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

The aim of this thesis is to establish whether a neural network (NN) can be used for emulation of simulated global crop production - retrieved from the computationally demanding dynamic global vegetation model (DGVM) Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS). It has been devoted to elaboration with various types of neural network architectures: Branched NNs capable of processing in

Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ

Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. The

Popular Abstract in Swedish En tredjedel av befolkningen i världens industrialiserade länder lider av allergi, t.ex. allergisk rinit (hösnuva). Trots detta vet man relativt lite om de cellulära och molekylära mekanismer som ligger till grund för det immunologiska svaret vid allergi. Genom att studera dessa mekanismer kan man hitta sätt att angripa dem, vilket förhoppningsvis kan leda till bättre lAllergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t