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Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_a/Agnes.txt - 2026-05-18

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

Acousmatic Concerts at IAC PROGRAMME 22–26 APRIL 2026 IAC.LU.SE Scan the QR code for detailed programme and artist bios! Wednesday, 22 April 17:00 & 19:00 ELIDE SULSENTI: Tundo, Sdraulig (Black Room) Performance with cello and headphones. Limited to 15 listeners per concert! Matteo Tundo – Cuoio (for cello and electronics) Charlie Sdraulig – Arc (for cello and electronics) Total duration: ca. 30 m

https://www.iac.lu.se/sites/iac.lu.se/files/2026-05/Intonal_2026_broschyr_A5_FINAL.pdf - 2026-05-20

Des de principis del segle xxi, una nova fornada d’estudis sobre la història del cooperativisme s’ha interessat per la influència d’aquest moviment d’emancipació en la configuració dels barris populars. Des d’una perspectiva urbana i microhistò- rica, la recerca sobre cooperatives i cooperativistes ha nodrit l’anàlisi de les relacions entre cooperativisme, obrerisme i associacionisme popular

IASPIS residency 5 September to 30 November 2023 Work sharing / Iaspis residencyThursday, 30 November 2023, at 15:00Location: Artist StudioPatricia Morosan (born 1984 in Romania / lives and works in Berlin and Athens) is an artist working with photography, text and sound. In her practice she approaches the duality of intimacy and identity. Exploring interdisciplinarity, her artistic work addresses

https://www.iac.lu.se/iaspis-residency/patricia-morosan - 2026-05-19