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This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Purpose: In patients with hemophilia B, treatment with extended half-life (EHL) recombi-nant factor IX allows for longer dosing intervals while providing equal or superior bleeding protection compared with standard half-life products. This enables flexible, individualized treatment schedules, which reduce the burden of prophylaxis and improve patient outcomes. This analysis compared the efficacy o

The Idefjorden Terrane of the Sveconorwegian Orogen, Fennoscandia, is known to be an area of comparatively juvenile Mesoproterozoic continental growth. Here we provide an improved model of crustal growth based on new coupled zircon U-Pb-O-Lu-Hf isotopic data on thirteen samples of mafic to intermediate plutonic rocks from different domains of the Idefjorden Terrane. The new data support a retreati

In the last decade, with the growing demand for efficient and more sustainable products that reduce our CO2 footprint, progresses in Additive Manufacturing (AM) have paved the way for optimized heat exchangers, whose disruptive design will heavily depend on predictive numerical simulations. Typical AM rough surfaces show limited resemblance to the artificially constructed rough surfaces that have

The aviation industry is under increasing pressure to mitigate its environmental impact, particularly concerning greenhouse gas emissions. Traditionally, commercial aviation has relied on conventional kerosene-based fuels. Recent advancements and environmental concerns have prompted the exploration of Sustainable aviation fuels (SAF), with initiatives like the Commercial Aviation Alternative Fuel

Utbildningsplan Konstnärligt masterprogram i fri konst (KAFKO) Konstnärligt masterprogram i fri konst, 120 högskolepoäng / Master Programme of Fine Arts, 120 credits Konstnärliga fakulteten KAFKO, Konstnärligt masterprogram i fri konst, 120 högskolepoäng Master Programme of Fine Arts, 120 credits Program med akademiska förkunskapskrav och med slutlig examen på avancerad nivå / Second cycle degree

https://www.khm.lu.se/sites/khm.lu.se/files/2025-11/KAFKO_utbildningsplan_20250916.pdf - 2026-05-16

Combining historical climatology and environmental history, this article examines the diverse range of strategies deployed by the city government of Barcelona (Catalonia, NE Spain) to confront the recurrent drought episodes experienced between 1626 and 1650. Our reconstruction of drought in Barcelona for the period 1525-1821, based on pro pluvia rogations as documentary proxy data, identifies the

Background: A unique feature of alveolar mast cells is their low high-affinity IgE receptor (FcεRI) expression. Recent discoveries in uncontrolled asthma suggest that the appearance of FcεRI-expressing alveolar mast cells may be a novel disease-specific feature of allergic asthma. This study investigates whether increased FcεRI-expressing alveolar mast cells are present in patients with mild aller

The 21st century has witnessed a revival of authoritarian and populist leaders, a new wave that has fundamentally changed the political landscape, earning it the title: The Age of the Strongman. This evolving style of leadership has been driven by “angry white men”, notably strengthening masculinity as a symbol of political authority. However, in recent years, the strongman archetype has met a ris

This review compares the methodology of published clinical studies investigating the extended-half-life (EHL) factor VIII (FVIII) products, rFVIIIFc (efmoroctocog alfa, Elocta®/Eloctate®), BAY 94-9027 (damoctocog alfa pegol, Jivi®), BAX 855 (rurioctocog alfa pegol, Adynovate®) and N8-GP (turoctocog alfa pegol, Esperoct®) including the phase 2/3 studies, A-LONG (NCT01181128), PROTECT VIII (NCT01580

Master’s Dissertation Structural Mechanics JOHAN HERLUF MATTSSON Report TV SM -5182 JO H A N H ERLU F M A TTSSO N EA R TH Q U A K E A N A LY SIS O F PIPE SU PPO R TS IN N U C LEA R PO W ER PLA N TS EARTHQUAKE ANALYSIS OF PIPE SUPPORTS IN NUCLEAR POWER PLANTS Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, November, 2012 (Pl). Fo

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5182.pdf - 2026-05-16

Organisation_MR_Group PhD Students E Lind B Lampinen A Lundberg H Olsson M Novén* J Brabec E Olsson F Durmo* A Seidemo Post-docs/Other A Bibic* F Testud C Gustafsson* P Brynolfsson* M Andersen A Rydhög F Szczepankiewicz N Spotorno* D Barron* Undergrad Students/Other T Rumetshofer U Gasay YM Bruun O Haglund A Fingerhut T Rosholm Research Radiographers T Owman B Hansson M Simic* L Wennberg* Seniors

https://www.msf.lu.se/sites/msf.lu.se/files/190110_organisation_mr_group.pdf - 2026-05-16

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Abstract in French À cause d'un manque de recherche empirique à la fois théorique et systématique, les processus d'intégration déterminés par l'innovation dans les zones transfrontalières sont toujours mal compris. S'éloignant de l'approche des systèmes régionaux d'innovation, de la recherche récente sur la proximité, et de la documentation sur les zones transfrontalières, cet article cherche à idDue to a lack of both theoretical and systematic empirical work, innovation-driven integration processes in cross-border areas are still poorly understood. Departing from the regional innovation system (RIS) approach, recent work on different forms of proximity, and the literature on cross-border areas, this paper seeks to identify in a conceptual way different stages in the development of cross-b

Workers at a copper and lead smelter in northern Sweden have a multifactorial exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male lead smelter workers, and compared with those of 10 male controls. Furthermore, copper and zinc Level

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami